Lisa Prach Email & Phone Number

Schlieren, Zurich, Switzerland

• Provide scientific expertise to design and deliver clinical studies and programs related to bacterial vaccine development• Propose, design and implement clinical development plans and regulatory strategies• Manage and supervise clinical team members• Proactively assess risks and develop solutions• Ensure delivery of milestones in terms of quality, budget and timelines• Closely collaborate with clinical operations team to ensure timely submissions and deliverables• Author and review clinical documents including protocols, statistical analysis plans, reports, and synopses

Basel, Switzerland

Basel, Switzerland

Basel Area, Switzerland

• Led epidemiology and risk management strategy of two neurological drug development programs through collaboration with members of the Global Program Teams• Led collaborations and partnerships with global cross-functional teams, including Medical Safety, Clinical Development, Regulatory Affairs and Quantitative Safety team members, to drive and ensure quantitative decision making based on data from literature and non-interventional studies in a proactive manner• Planned and oversaw project-level activities; manage key project tasks; ensure effective partnerships with vendors• Implemented innovative approaches to evaluate drug safety during pregnancy• Put epidemiology information into context and provide epidemiological support to safety management teams with a strong focus on quantitative contextualization of safety data• Authored epidemiological sections of documents for health authorities, such as Periodic Safety Update Reports, Health Authority requests, Risk Management Plans and interim analysis reports• Ensured deliverables are met on time, within budget and with high quality for rigorous, fact-based decision making• Communicated project findings through presentations at scientific/medical conferences and publications in peer-reviewed journals

San Francisco, Namibia, Eswatini

• Evaluated a new highly sensitive rapid diagnostic test for malaria and measured the asymptomatic malaria burden in Zambezi Region, Namibia by leading the implementation of a 4,300+ participant cross-sectional study. Duties included: o Developing the study design and protocol, sampling frame, informed consent forms, data collection tools, questionnaires, database, and training materials o Creating and managing the $630,000 USD study budget and the 18 month study timeline and ensuring that all activities are completed within time and budget o Managing the hiring, training, and field activities of a 22-member team o Coordinating partner organization activities, securing Material Transfer Agreements, sub-contracts, and IRB approval, and liaising with stakeholders to ensure study success• Identified innovative malaria elimination strategies in low transmission settings by managing a phase III cluster randomized controlled trial in Swaziland measuring the effectiveness and feasibility of reactive focal presumptive treatment versus reactive case detection. Duties included: o Supervising study implementation and adherence to protocol by liaising with partner organizations and through bimonthly site visits o Overseeing Institutional Review Board (IRB) renewal and modifications, partner sub-contracts, and study budget totaling $1.5 million USD o Analyzing study data, producing interim reports, and writing scientific manuscripts

San Francisco Bay Area

• Determined care-seeking behavior associated with suspected malaria, diarrhea, and pneumonia in Nigeria by analyzing, and interpreting quantitative data from over 250 private medicine vendors and 5,000 client interviews using Stata; published findings as peer-reviewed journal articles• Identified under-served areas to prioritize for health systems strengthening interventions and policy changes in Nigeria by mapping and analyzing the geographic distribution and density of private medicine vendor outlets and health facilities in local government areas of 16 states• Analyzed Demographic Health Services data from Nigeria, performed literature reviews and identified relevant references to prepare grant applications for future funding opportunities• Developed a questionnaire and survey tools for an evaluation of a randomized controlled trial of a conditional cash transfer program for HIV-infected pregnant women in Nigeria• Reviewed submitted manuscripts to determine their suitability for publication

San Francisco Bay Area/South Africa

• Measured the HIV/AIDS care continuum in North West Province, South Africa by managing quantitative data collection for the pre-intervention cross-sectional survey and cost effectiveness analysis of a CDC-funded HIV prevention program • Trained and supervised 35 staff members administering a population-based, electronic survey and HIV counseling and testing in 43 enumeration areas• Developed project plans and timelines, standard operating procedures, ethical review board documents, data collection tools and training materials to achieve project goal of 1,150 surveys in seven weeks of data collection• Solved logistical challenges, monitored recruitment, strategized work flow, oversaw data entry and quality assurance• Oversaw dried blood spot collection, transport and viral load results reporting by two independent laboratories• Liaised with staff and officials from non-governmental organizations, national and local ministries of health, academia and private corporations to achieve project goals• Published a manuscript describing the external quality assurance program developed for the viral load assays from dried blood spots

Richmond, Ca

• Managed cystic fibrosis newborn screening surveillance program for California by tracking, referring and following cases through five years using an on-line database • Analyzed screening program data on 2.5 million newborns using SAS and SQL • Evaluated efficiency and effectiveness of the screening program by comparing health outcomes in screened and non-screened populations• Provided technical assistance to specialty care centers and wrote reports and presentations summarizing screening performance

Berkeley, Ca

• Investigated drug-resistant tuberculosis pathogenesis and transmission by initiating a cohort study of high risk populations in Harare, Zimbabwe• Developed standard operating procedures, recruited participants, administered questionnaires, developed data collection tools and databases, managed data entry and quality assurance checks, and wrote technical reports• Performed contact tracing and screening of household contacts of all drug-resistant tuberculosis patients enrolled• Analyzed drug-resistant tuberculosis surveillance data from California to determine population characteristics, risk factors, clinical outcomes and trends over time using Stata and published findings in a peer-reviewed journal

Zanzibar, Tanzania

• Managed a regional malaria surveillance program consisting of seven head nurses and 40 community health workers in rural Zanzibar; ensured adherence to protocols, stocking of supplies, proper completion of forms and storage of samples; directed study close-out activities• Investigated malaria transmission networks and hotspots by creating maps of incident malaria cases over time using a geographic information system (GIS)• Increased GIS capacity in Zanzibar by preparing training sessions and leading tutorials with Ministry of Health staff

Berkeley, California

• Managed medical surveillance, infection control procedures, waste management, facility activity and operation of a multi-departmental core facility• Trained new users in proper use of personal protective equipment and safety procedures• Directed experimental protocol development and laboratory supply ordering • Mediated communications between facility users and campus services to maintain research efficiency and proper infection control measures

• Developed and initiated an independent research project to examine metabolic pathways of Mycobacterium tuberculosis associated with phagosome-lysosome fusion arrest• Determined the production pathways, structures, and cellular location of two diterpene lipids unique to M. tuberculosis and complemented a diterpene deficient strain to show that two genes are necessary and sufficient for diterpene production• Analyzed lipid metabolism in clinical strains of M. tuberculosis in South Africa through external funding secured from the UC Berkeley Center for Emerging and Neglected Diseases• Cloned M. tuberculosis genes into E. coli expression vectors, expressed and purified proteins, and crystallized and solved the X-ray crystal structure of one protein• Mentored one undergraduate, two graduate rotation students and one research assistant in molecular biology techniques, experimental design, and data analysis and designed independent, achievable research projects and supervised progress towards experimental goals

Mph, Epidemiology

Phd, Molecular And Cell Biology

Bachelor Of Science, Biological Science

Bachelor Of Science - Bs, Biology/Biological Sciences, General