Lisseth Silva Email & Phone Number

Paris, FR

Paris, Île-de-France, France

Immunotherapies, Engineering of CAR T Cells

Paris, Île-de-France, France

-Identify new therapeutic approaches for metastatic uveal melanoma and study the mechanism of action.-In vitro testing of drug molecules as single agents or combination treatments targeting various signaling pathways involved in the disease progression of uveal melanoma.

Paris, Île-de-France, France

-Conducted a comprehensive study of the metabolic characteristics of uveal melanoma cells carrying a splicing factor mutation to determine its oncogenic role.-Performed cell culture operations per SOPs to maintain sterility and health of cells.-Monitored the viability of cells under various experimental conditions.-Performed cell-based assays and western.

Greater Boston Area

-Executed, managed, and coordinated a clinical research project evaluating brain scans for neuroinflammation in patients with motor neuron diseases using combined Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET), a state of the art imaging technique.-Executed, managed, and coordinated various Expanded Access Programs (EAPs) for.

Greater Boston Area

-Executed, managed, and coordinated two clinical research projects, ensuring strict adherence to study protocol. The first project investigates the clinical characterization of an oxytocin-deficient state in hypopituitary patients. The second project investigates the effects of repeat doses of intranasal oxytocin in obese adults.-Interacted directly with.

Boston, Massachusetts

• Designed, synthesized, and evaluated analogs as kinase-targeted inhibitors of Trypanosoma brucei, the parasite that causes the neglected tropical disease African Sleeping Sickness.
• Optimized azindole-derived hit compounds to improve potency and physicochemical properties as means to uncover new Trypanosoma brucei inhibitors.

Boston, Massachusetts

• Taught organic chemistry I and II laboratory sections, and assisted students with experiments and any questions regarding the course.

Boston, Massachusetts

• Analyzed databases of companies with drug donation programs who participated in the London Declaration Program, which committed to eradicate or prevent transmission of at least 10 Neglected Tropical Diseases by 2020.

Bristol, Rhode Island

• Synthesized various substrates using different Lewis acids to obtain C-glycosyl compounds with the highest yield and purity and measured their affinity to bovine serum albumin.

Bristol, Rhode Island

• Studied the cell biology of Entamoeba species, focusing on their behavior and kin discrimination.
• Monitored the effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase (EhADH2) and trophozoite growth.
• Tested inhibitor properties of pyrazoline analogues against EhADH2.

New York, New York

• Researched gene mutations related with brain malformations and investigated how these genes assist in the construction of the brain.
• Analyzed the cell morphology of layer II and III neurons and spine density in Lis1-GFP mice.
• Analyzed the Lis1 conditional knockout mice model to investigate the role of Lis1 in neurons of the CA1 region of the hippocampus in young adolescent mice.

Master Of Science - Ms, Biological And Biomedical Sciences

Thesis: Study of the oncogenic consequences of SF3B1 mutations in uveal melanoma

Master Of Science - Ms, Chemistry

Thesis: Hit-to-lead optimization of kinase-targeted inhibitors of Trypanosoma brucei growth.

Bachelor Of Science - Bs, Chemistry And Biology

Activities and Societies: President of the American Chemical Society Student Affiliates (2011-2012), Vice-president Pre-med/pre-vet.