Li-Yuan Chen

Li-Yuan Chen Email and Phone Number

Post-Doctoral Fellow | Ph.D in Neuroscience | Electrophysiology | Epilepsy | Narcolepsy | Sleep
Li-Yuan Chen's Location
Switzerland, Switzerland
About Li-Yuan Chen

Brain electrophysiology ‒ these are the curiosities that have led me to study neural activity in laboratory models of epilepsy and narcolepsy using, respecitvely, tetrodes and electroencephalography (EEG). Inherent in my docotral and post-doctoral research is understanding the elusive relation between action potentials, brain activity, and disease pathology. By incorporating MATLAB coding in my analysis, I have found that the inhibitory interneurons participated in the generation of epileptic brain activity more than the excitatory principal cells; at present, I am investigating the efficacy of a novel treatment for nacolepsy type 1 (NT1). Altogether, my scientific experiments contribute, through first-author peer-reviewed publications, to the literature highlighting our understanding of different neurological diseases.Unexpected to me at the beginning, this neuroscientific pursuit of mine has also took me on a journey to experience diveristy in the society. I am regularly challenged to establish common grounds in my research collaborations by learning and reconciling different scientific and industrial interests. Supervising juniors trainees of various backgrounds to complete their research projects demanded an enrichment in my explanation and teaching of the scientific method. Although effortful at times, I hope that one day, by acquiring fluency in French and German, I will be able to connect with ‒ and be surprised by ‒ the broader society. Professional Interests: neuroscience, electrophysiology, tetrodes, basic epilepsy research, electroencephalography (EEG), sleep research, narcolepsy, neural oscillation, and brain rhythm

Li-Yuan Chen's Current Company Details

Post-Doctoral Fellow | Ph.D in Neuroscience | Electrophysiology | Epilepsy | Narcolepsy | Sleep
Li-Yuan Chen Work Experience Details
  • University Of Lausanne - Unil
    Postdoctoral Researcher
    University Of Lausanne - Unil Feb 2022 - Mar 2024
    Lausanne, Vaud, Switzerland
    I am investigating about the mechanisms of sleep.
  • Krembil Research Institute
    Postdoctoral Researcher
    Krembil Research Institute Oct 2020 - Oct 2021
    Toronto, Ontario, Canada
    I spearheaded an in vivo optical imaging project aimed at improving our understanding of the seizure initiation mechanisms.
  • The Montreal Neurological Institute
    Phd Student
    The Montreal Neurological Institute Jun 2015 - Sep 2020
    Dr. Massimo Avoli'S Laboratory
    I utilized in vitro models of epiletiform synchronization and in vivo models of epilepsy to study the cellular mechanisms underlying seizure generation. I independently executed experiments using tetrodes or glass pippettes to record neuronal and/or local field potential activities in in vitro models of ictogenesis; afterwards, I analyze my data by writing custom Matlab script. In addition, I perform in vivo experiments with colleagues to study epileptogenesis by manipulating neuronal activity with light. Despite the different conditions and techniques in these experiments, my results - which were published in peer-reviewed articles - had all emphasized the role of inhibitory mechanisms in seizure generation. Altogether, my PhD training allowed me to obtain and to hone in science inquiry and communication skills.
  • Mcconnell Brain Imaging Centre, Montreal Neurological Institute
    Undergraduate Student Researcher
    Mcconnell Brain Imaging Centre, Montreal Neurological Institute Jan 2014 - Jun 2015
    Dr. Sylvain Baillet'S Laboratory (Neurospeed: Dynamic Neuroimaging Laboratory)
    In this experience, I explored different areas of neuroscience research by participating in 2 research projects.The goal of the first project - titled "OMEGA Database" - was to develop the first online database for Magnetoencephalography (MEG) imaging data. In the project, I assisted a post-doctoral fellow to develop database by executing UNIX and MySQL programming code. We also collaborated with professional program developers to troubleshoot and to tailor our database. During the project, I summarized our progress in a report to the grant agency that supported our work.Subsequently, I carried out my undergraduate honours thesis project "Heart Rate Fluctuations Induced by Visual Attention." In this project, I used Matlab and Brainstorm softwares to extract electrocardiogram (ECG) and behavioural data. I also performed statistical analysis, paired-sample t-test with false discovery rate correction, to test for significant effects in my dataset. My preliminary analyses revealed a significant difference between the the heart rates of fast and slow behavioural reaction time.
  • Mcgill University
    Undergraduate Student
    Mcgill University Jan 2014 - Jun 2014
    Laboratory In Neurobiology (Biol 389)
    I executed 3 mini experiments in collaboration with a partner in 3 different model animals using 3 different laboratory techniques: 1) electropharngeogram recordings in C. elegans pharynx, 2) extracellular field recordings in rat hippocampus, and 3) intracellular recordings in leech Retzius cell. We designed the experimental questions then collected data with Axon pClamp software (Molecular Devices). At the end of the data collection, we performed statistical analysis using R and Microsoft Excel. Finally, we independently interpreted our results in our lab reports. Through the class, I learned to design and to execute research project as well as to interpret and to communicate my findings.
  • Centre Universitaire De Santé Mcgill | Mcgill University Health Centre
    Undergraduate Student Researcher
    Centre Universitaire De Santé Mcgill | Mcgill University Health Centre Jan 2013 - Dec 2013
    Dr. Nathalie Lamarche-Vane'S Laboratory
    I gained insights into cell and molecular biological research by using the NTAP-Tag technique to extract the proteins binding to the PRD domain of cdGAP. In this project, I passaged, collected, and lysed NMuMG cells to obtain the total cell lysate to which I applied the NTAP-Tag procedures. Finally, I ran western blot to visualize the proteins isolated by the NTAP-Tag protocol. Through the project, I learned to execute scientific experiments independently and to consult the literature. Afterwards, I was convinced to pursue advance studies in science and further opportunities in cutting-edge research.

Li-Yuan Chen Skills

Teamwork Communication Neuroscience Data Analysis Community Outreach Electrophysiology Microsoft Office Matlab Leadership Western Blotting Public Speaking Event Planning

Li-Yuan Chen Education Details

Frequently Asked Questions about Li-Yuan Chen

What is Li-Yuan Chen's role at the current company?

Li-Yuan Chen's current role is Post-Doctoral Fellow | Ph.D in Neuroscience | Electrophysiology | Epilepsy | Narcolepsy | Sleep.

What schools did Li-Yuan Chen attend?

Li-Yuan Chen attended Mcgill University, Mcgill University, Semiahmoo Secondary School.

What are some of Li-Yuan Chen's interests?

Li-Yuan Chen has interest in Social Services, Education, Arts And Culture, Economic Empowerment.

What skills is Li-Yuan Chen known for?

Li-Yuan Chen has skills like Teamwork, Communication, Neuroscience, Data Analysis, Community Outreach, Electrophysiology, Microsoft Office, Matlab, Leadership, Western Blotting, Public Speaking, Event Planning.

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