Brain electrophysiology ‒ these are the curiosities that have led me to study neural activity in laboratory models of epilepsy and narcolepsy using, respecitvely, tetrodes and electroencephalography (EEG). Inherent in my docotral and post-doctoral research is understanding the elusive relation between action potentials, brain activity, and disease pathology. By incorporating MATLAB coding in my analysis, I have found that the inhibitory interneurons participated in the generation of epileptic brain activity more than the excitatory principal cells; at present, I am investigating the efficacy of a novel treatment for nacolepsy type 1 (NT1). Altogether, my scientific experiments contribute, through first-author peer-reviewed publications, to the literature highlighting our understanding of different neurological diseases.Unexpected to me at the beginning, this neuroscientific pursuit of mine has also took me on a journey to experience diveristy in the society. I am regularly challenged to establish common grounds in my research collaborations by learning and reconciling different scientific and industrial interests. Supervising juniors trainees of various backgrounds to complete their research projects demanded an enrichment in my explanation and teaching of the scientific method. Although effortful at times, I hope that one day, by acquiring fluency in French and German, I will be able to connect with ‒ and be surprised by ‒ the broader society. Professional Interests: neuroscience, electrophysiology, tetrodes, basic epilepsy research, electroencephalography (EEG), sleep research, narcolepsy, neural oscillation, and brain rhythm
-
Postdoctoral ResearcherUniversity Of Lausanne - Unil Feb 2022 - Mar 2024Lausanne, Vaud, SwitzerlandI am investigating about the mechanisms of sleep. -
Postdoctoral ResearcherKrembil Research Institute Oct 2020 - Oct 2021Toronto, Ontario, CanadaI spearheaded an in vivo optical imaging project aimed at improving our understanding of the seizure initiation mechanisms. -
Phd StudentThe Montreal Neurological Institute Jun 2015 - Sep 2020Dr. Massimo Avoli'S LaboratoryI utilized in vitro models of epiletiform synchronization and in vivo models of epilepsy to study the cellular mechanisms underlying seizure generation. I independently executed experiments using tetrodes or glass pippettes to record neuronal and/or local field potential activities in in vitro models of ictogenesis; afterwards, I analyze my data by writing custom Matlab script. In addition, I perform in vivo experiments with colleagues to study epileptogenesis by manipulating neuronal activity with light. Despite the different conditions and techniques in these experiments, my results - which were published in peer-reviewed articles - had all emphasized the role of inhibitory mechanisms in seizure generation. Altogether, my PhD training allowed me to obtain and to hone in science inquiry and communication skills. -
Undergraduate Student ResearcherMcconnell Brain Imaging Centre, Montreal Neurological Institute Jan 2014 - Jun 2015Dr. Sylvain Baillet'S Laboratory (Neurospeed: Dynamic Neuroimaging Laboratory)In this experience, I explored different areas of neuroscience research by participating in 2 research projects.The goal of the first project - titled "OMEGA Database" - was to develop the first online database for Magnetoencephalography (MEG) imaging data. In the project, I assisted a post-doctoral fellow to develop database by executing UNIX and MySQL programming code. We also collaborated with professional program developers to troubleshoot and to tailor our database. During the project, I summarized our progress in a report to the grant agency that supported our work.Subsequently, I carried out my undergraduate honours thesis project "Heart Rate Fluctuations Induced by Visual Attention." In this project, I used Matlab and Brainstorm softwares to extract electrocardiogram (ECG) and behavioural data. I also performed statistical analysis, paired-sample t-test with false discovery rate correction, to test for significant effects in my dataset. My preliminary analyses revealed a significant difference between the the heart rates of fast and slow behavioural reaction time. -
Undergraduate StudentMcgill University Jan 2014 - Jun 2014Laboratory In Neurobiology (Biol 389)I executed 3 mini experiments in collaboration with a partner in 3 different model animals using 3 different laboratory techniques: 1) electropharngeogram recordings in C. elegans pharynx, 2) extracellular field recordings in rat hippocampus, and 3) intracellular recordings in leech Retzius cell. We designed the experimental questions then collected data with Axon pClamp software (Molecular Devices). At the end of the data collection, we performed statistical analysis using R and Microsoft Excel. Finally, we independently interpreted our results in our lab reports. Through the class, I learned to design and to execute research project as well as to interpret and to communicate my findings. -
Undergraduate Student ResearcherCentre Universitaire De Santé Mcgill | Mcgill University Health Centre Jan 2013 - Dec 2013Dr. Nathalie Lamarche-Vane'S LaboratoryI gained insights into cell and molecular biological research by using the NTAP-Tag technique to extract the proteins binding to the PRD domain of cdGAP. In this project, I passaged, collected, and lysed NMuMG cells to obtain the total cell lysate to which I applied the NTAP-Tag procedures. Finally, I ran western blot to visualize the proteins isolated by the NTAP-Tag protocol. Through the project, I learned to execute scientific experiments independently and to consult the literature. Afterwards, I was convinced to pursue advance studies in science and further opportunities in cutting-edge research.
Li-Yuan Chen Skills
Li-Yuan Chen Education Details
-
Integrated Program In Neuroscience (Ipn) -
Honours In Neuroscience -
Semiahmoo Secondary SchoolHigher Levels In Chemistry, Physics, And Mathematics
Frequently Asked Questions about Li-Yuan Chen
What is Li-Yuan Chen's role at the current company?
Li-Yuan Chen's current role is Post-Doctoral Fellow | Ph.D in Neuroscience | Electrophysiology | Epilepsy | Narcolepsy | Sleep.
What schools did Li-Yuan Chen attend?
Li-Yuan Chen attended Mcgill University, Mcgill University, Semiahmoo Secondary School.
What are some of Li-Yuan Chen's interests?
Li-Yuan Chen has interest in Social Services, Education, Arts And Culture, Economic Empowerment.
What skills is Li-Yuan Chen known for?
Li-Yuan Chen has skills like Teamwork, Communication, Neuroscience, Data Analysis, Community Outreach, Electrophysiology, Microsoft Office, Matlab, Leadership, Western Blotting, Public Speaking, Event Planning.
Not the Li-Yuan Chen you were looking for?
-
Li-yuan Chen
Artificial Intelligence Intern At Ptsc Pershing Technology Services Corporation 北祥科技服務股份有限公司Raleigh, Nc -
-
-
Free Chrome Extension
Find emails, phones & company data instantly
Aero Online
Your AI prospecting assistant
Select data to include:
0 records × $0.02 per record
Download 750 million emails and 100 million phone numbers
Access emails and phone numbers of over 750 million business users. Instantly download verified profiles using 20+ filters, including location, job title, company, function, and industry.
Start your free trial