Les Kondejewski Email & Phone Number

Toronto, Canada Area

• Management of Genome Canada programs and funded projects
• Definition and optimization of project management processes to increase efficiency

• Provide advice and guidance to industrial and academic clients in a range of areas:
• Biomarker Services - platform selection, discovery, validation, biomarker prioritization, high throughput assays
• Business Services - scientific due diligence, operations auditing, project and collaboration management, scientific management, process documentation, SOPs & GLP
• Writing Services - scientific and medical writing and editing for manuscripts, reports, patents, R&D Tax Credits, business development and marketing packages etc.

Montreal, Canada Area

• Provide expert knowledge in the areas of personalized medicine, biomarker research, biotechnology, oncology, CNS/neuroscience and drug discovery and development
• Deliver complete medical, health and life sciences writing services

Montreal, Canada Area

• Work with client teams to develop and implement companion diagnostic tests
• Facilitate development and commercialization plans for targeted therapies and their companion diagnostics, including assessment of market access and test adoption hurdles

• Managed 20+ collaborative translational medicine/molecular diagostic programs to provide the company with a steady source of revenue and a solid international Pharma/Biotech customer base. Programs involved the.
• Led all aspects of 10 oncology target discovery programs allowing the company to create revenue generating alliances (Abbott, Biogen-Idec, ICOS). These programs generated 100’s of novel cell surface immunotherapeutic.
• Assumed a senior leadership role responsible for all aspects of program planning, execution, report preparation, data delivery and partner follow-up to achieve on time and on budget delivery of high-value biomarkers.

• Managed the successful setup of Caprion’s proteomics platform allowing the company to offer revenue generating proteomics services. Setup required the development and standardization of all methods (preparation of.
• Responsible for the leadership of proteomics programs in oncology cell surface target discovery in partnership with Pharma/Biotech collaborators.

• Established and managed the Protein Chemistry laboratory for core supporting activities in peptide design and synthesis and protein purification/analysis.
• Responsible for evaluation and development of proteomic methods for peptide phosphoprofiling, plasma high abundance protein depletion, fractionation methodologies and process automation.
• Leadership of a successful amyotrophic lateral sclerosis program in collaboration with external academic labs. Evaluated M&A opportunities in structural biology & small molecules.

• Established the Structural Biology group for the analysis of aggregating protein systems (prions, Cu/Zn-superoxide dismutase).
• Development of conformation-specific antibodies to prion proteins.
• Development of in vitro and cell-based assays to identify inhibitors of SOD-1 aggregation and studies to identify mechanism of aggregation, including analysis of mutants, identification of co-aggregating proteins and.

Management of numerous projects and collaborations involving design and synthesis of appropriate peptides, peptidomimetics and conformationally-constrained peptides:- design and synthesis of antifreeze proteins (Queens University, AFP Inc.)- development of conformation-specific ligands to prion protein (Bayer Inc.)- development of cyclic antimicrobial.

Development of novel conformationally-constrained antimicrobial peptides based on the cyclic peptide Gramicidin S. Project involved peptide design, development of synthesis and purification strategies, structural and biological characterization and determination of structure-activity relationships. Developed peptides possessed low toxicity and high broad.

Ph.D., Biochemistry - Protein Chemistry

Development of antibody drug conjugates for cancer immunotherapy.

Bsc Hons, Biochemistry