As a seasoned expert in upstream bioprocess development, I’m known for my science-based approach while working towards practical solutions and keeping applicability in mind. My proficiency in designing and optimizing bioprocesses is built on a deep understanding of the details, complemented by a track record in solving complex process-related problems. Colleagues see me as a valuable knowledge resource for bioreactor technology, and I am certified in facilitating root cause analysis teams. My core values integrity, dedication, objectivity, and modesty, help me to have effective collaborations and achieve project goals. It is my ambition to work in fields of biotechnology such as biobased chemicals, bioplastics, or biofuels, produced from renewable resources. My hands-on experience in microbial fermentation from my PhD research on industrial penicillin fermentation, complemented with experience in process optimization, robust knowledge base and eagerness to contribute to a more sustainable world, positions me as a strong asset for organizations focusing on solutions for the biobased economy and the energy transition – especially in R&D and process development roles.
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Senior Scientist Viral VectorNecstgen Nov 2023 - PresentLeiden, South Holland, NetherlandsDevelopment of production processes and GMP manufacturing of Viral Vectors for ATMPs. -
Senior Scientist Upstream Process DevelopmentJanssen Vaccines Oct 2022 - Aug 2023Leiden, South Holland, NetherlandsEarly and late phase development and optimization of cell culture processes, in particular for the production of viral vectors. Identified way to increase cell-specific productivity of adenovirus. Developed dual source single-use perfusion device. Prepared development plans for adeno-associated viral vector production. Advised commercial plant on how to implement new adeno-associated viral vector process. Sponsored Single Use Bioreactor replacement project. Improved insight into freeze-thaw infectivity loss of adenoviral seeds. Supervised development of Mechanistic and Machine Learning models for RNA production by external partner. Trained colleagues in root cause analysis tools.
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Scientist Upstream Process DevelopmentJanssen Vaccines Apr 2012 - Oct 2022Leiden, The NetherlandsDeveloped Upstream Process Platform for adeno-vectored vaccines and cell culture-based influenza vaccines: process development, standardization, optimization, scale-up and characterization, medium development and qualification. Optimized commercial-scale high cell density perfusion cell cultures. Accomplished several successful technology transfers and provided manufacturing support to GMP production facilities for Janssen's COVID-19 vaccine and other vaccine candidates. Improved online process monitoring in GMP via Simca online. Developed reduced scale models to support process characterization. Facilitated Root Causes Analyses in R&D and GMP departments. Experience with project and line management in a lean manufacturing culture.
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Phd StudentDelft University Of Technology Jan 2006 - Mar 2012Delft, South Holland, NetherlandsPhD research in the field of Bioprocess Technology, in particular metabolic responses to imperfect mixing in large-scale bio-reactors. Thesis title: "A scale-down study of the industrial penicillin fermentation using quantitative metabolomics". Advisors: prof. dr. J.J. Heijnen and dr. W.M. van Gulik. Experimental lab work and mathematical modeling. -
ResearcherDsm (Via Manpower) Oct 2010 - Feb 2011Metabolomics Benchmark Study, Contract Research for DSM Biotechnology Center. Yeast fermentations and intracellular metabolite analysis.
Lodewijk De Jonge Education Details
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NexsteppCertified -
Life Science & Technology
Frequently Asked Questions about Lodewijk De Jonge
What company does Lodewijk De Jonge work for?
Lodewijk De Jonge works for Necstgen
What is Lodewijk De Jonge's role at the current company?
Lodewijk De Jonge's current role is Bioprocess Technology Expert.
What schools did Lodewijk De Jonge attend?
Lodewijk De Jonge attended Nexstepp, Delft University Of Technology, Leiden University.
Who are Lodewijk De Jonge's colleagues?
Lodewijk De Jonge's colleagues are Roxanne Wever, Adam H., Lynn De Boer, Lara Ottaviani, Yasmin Habani, Conor Vogelzang, Robin Van Wissen.
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