Loek Eggermont Email & Phone Number

Utrecht, Netherlands

Amsterdam

Amsterdam, Noord-Holland, Nederland

Boston, Massachusetts, Verenigde Staten

• Laboratory for Advanced and Multifunctional Polymeric Biomaterials - Development of injectable biomaterials to manipulate immune responses
• Optimized immunoinstructive cryogel scaffolds for T cell transfer and regulatory T cell polarization
• Characterized immune cells in mice after vaccination with SARS-CoV-2 biomaterial vaccines
• Developed methods to retrieve immune cells from biomaterials for flow cytometry
• Managed projects on cancer immunotherapy, autoimmune disease and vaccine development

Nijmegen, Gelderland, Nederland

• Polymer nanofilaments as artificial antigen-presenting cells for efficient cancer immunotherapy
• Managed projects on aAPC development to promote T-cell activation in vitro and in mice
• Generated peptide-MHC complexes for antigen-specific T cell stimulation
• Communication of results via publications and presentations

Nijmegen, Gelderland, Nederland

• A synthetic dendritic cell platform for immune activation
• Nanomaterial development to control and study human T cell activation in vitro
• Setting up and managing multidisciplinary collaborations with chemists and immunologists
• Managing and supervising student projects on T cell immunology
• Writing of papers, thesis and patent application on artificial antigen-presenting cells

Nijmegen, Gelderland, Nederland

In this internship I worked on the development of a novel liposomal peptide-based treatment for uveal melanoma. I developed several formulations of pH-sensitive liposomes modified with cell-penetrating peptides and tested them for their stability, cell uptake and cytoplasmic delivery using confocal fluorescence imaging and FACS. Furthermore, I investigated.

Nijmegen En Omgeving, Nederland

As a private tutor I teached mathematics, physics, chemistry and biology to 1 HAVO and 6 VWO students to help them graduate high school.

Nijmegen

The human-Lactoferrin derived Cell-Penetrating Peptide (hLF) can efficiently internalize cargo into living cells, but endosomal entrapment is still a problem. Conjugation of stearyl and trifluoroquinoline moieties to cell-penetrating peptides is known to induce endosomal escape and improve cytoplasmic delivery. In this internship, a modular.

Athens, Georgia, Verenigde Staten

As a visiting student in Athens, I tested the potency of the new cyclooctyne BCN for the bioorthogonal labeling of both intracellullar and cell surface sugar chains. BCN and several analogues of this compound were compared with DIBO for their ability to react with azido groups on ManNAz-labeled Jurkat and CHO cells.

Nijmegen, Gelderland, Nederland

Recently, a new group of cyclooctynes with a very straightforward synthesis, the bicyclononynes, was discovered as a candidate for use in the extremely selective Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC) both in vitro and in vivo. As part of the BSc program, in this internship it was attempted to synthesize two new bicyclononynes to be used as new.

Doctor Of Philosophy - Phd, Immunology

Master Of Science (Ms), Master Molecular Life Science

Education record

Bachelor Of Science (Bsc), Molecular Life Sciences

Propedeuse & bachelor cum laude

Vwo Nt+Ng, Exams In Ancient Greek, Biology, Chemistry, Dutch, English, Mathematics, Physics

Cum Laude