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I am a senior drug hunter whose broad expertise ranges from pharmaceutics, physicochemical properties of drugs, such as logP, logD, pKa and solubility, to ADME and DMPK project support, as well as library design. I have led and contributed to several projects in the Oncology, Infectious Diseases and Ophthalmology disease areas. Several of these projects and generated candidates in the clinical setting. I have extensive DMPK project work with supervisory experience, have been a mentor to several scientists at Ph.D. and non-Ph.D. level and I have collaborated extensively with many high level scientists across my career. I have co-written, or contributed to, relevant sections of investigator's brochures (IB) as well as relevant sections of the Common Technical Document (CTD) for IND and NDA submission as well as internal nomination documents, leading to development and clinical studies.I am known for leading successful scientific initiatives as well as leadership and mentorship across several organizations, with a solid publication record in peer-reviewed journals, as well as many invited presentations at universities and industrial conferences.I am very experienced in physicochemical, ADME and PK model building and published extensively in the field. I have also experience in data mining and curation, and statistical models. Furthermore, I have a strong foundation and expertise in physicochemical properties such as logP, logD, pKa and solubility, and drug design.I am attentive to details, possess a "can do" attitude and have participated to the formation of consortia across the industry as well as having experience in due diligence collaborations, forming relationships and contacts very quickly. I also have CRO experience and some due diligence and consortia agreements. Strategic aspects of projects and research and development tool, planning and budgetary aspects are also part of my responsibilities.
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Adjunct FacultyUniversity Of MinnesotaUnited States -
Adjunct FacultyUniversity Of Minnesota Sep 2021 - PresentMinneapolis And St. Paul, Minnesota, UsSeminars, lectures and short courses -
Principal/FounderCmaxdmpk May 2021 - PresentDMPK and ADME consulting. www.cmaxdmpk.com
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Affiliate Research Professor In The Department Of Chemistry And Chemical BiologyNortheastern University Aug 2019 - PresentBoston, Ma, UsSeminars, lectures and short courses -
Senior Director, DmpkAlkermes, Inc. Jan 2017 - May 2021Dublin, IePharmacokinetics and drug metabolism of early drug discovery and development. In vivo and in vitro screens, physicochemical properties and their application to drug design.Pharmacokinetics and pharmacodymanics modeling. Bioanalysis. -
Senior ConsultantSelf-Employed Sep 2016 - Dec 2016ADME, DMPK, PKPD, Physicochemical properties, in silico ADME, logP, logD, solubility, pKa
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Principal Research InvestigatorBiogen Idec Oct 2014 - Aug 2016Cambridge, Ma, UsPhysicochemical properties such as logP, logD, pKa and solubility, DMPK and ADME modeling, Drug Design, CRO expertise, data management and modeling. Prodrug expertise. -
DirectorNovartis Institutes For Biomedical Research Mar 2010 - Oct 2014Basel, Baselstadt, ChPharmacokinetics and drug metabolism project work and DMPK representation in Oncology and Infectious Diseases as well as Ophthalmology projects. DMPK modeling and prediction in silico and in vivo-in vivo correlation. Physicochemical properties (in vitro and in silico) and their impact on ADME. -
Adjunct ProfessorNortheastern University Mar 2011 - Feb 2013Boston, Ma, UsLecturing on ADME, DMPK, physicochemical properties and Drug Design -
Senior Research Investigator IiNovartis Institutes For Biomedical Research 2008 - 2010Basel, Baselstadt, ChProject DMPK representation in Oncology and Infectious Diseases as well as Ophthalmology projects. DMPK modeling and prediction in silico and in vivo-in vivo correlation. Physicochemical properties (in vitro and in silico) and their impact on ADME. PKPD modeling -
Senior Research Investigator INovartis Institutes For Biomedical Research 2006 - 2008Basel, Baselstadt, ChProject team representation in drug discovery across the entire DMPK function for early candidates. In silico modeling, physicochemical properties application to drug design. -
Associate Research FellowPfizer Jan 2001 - Feb 2006New York, New York, UsSupervision of three to five laboratory assistants. Development and implementation of physicochemical properties high throughput screening methods (logP/logD). Automation of equilibrium solubility determinations. Computational chemistry approaches applied to physicochemical properties prediction. Development of medium-to-high throughput screening methods for oxidative stability assessment. Advisory role on drug-like properties with emphasis on oral drug delivery. Physicochemical modeling of in-vivo distribution phenomena. DMPK data analysis using WinNonLin. Preparation and presentation of seminars on the above topics, aimed at DM and medicinal chemistry scientists. -
Senior Research InvestigatorPfizer Jun 1998 - Jan 2001New York, New York, UsDiscovery- Molecular Properties Group- Supervision of three to four laboratory assistants. Development and implementation of physicochemical properties high throughput screening methods (logP/logD). Automation of equilibrium solubility determinations. Computational chemistry approaches applied to physicochemical properties prediction and ADME porperties. Development of medium-to-high throughput screening methods for oxidative stability assessment. Advisory role on drug-like properties with emphasis on oral drug delivery. Preparation and presentation of seminars on the above topics, aimed at the DM and medicinal chemistry scientists. -
Senior Research InvestigatorPfizer Jan 1997 - Jun 1998New York, New York, UsOral Drug Delivery: Early Candidates Group. Supervision of two laboratory assistants. Computational chemistry: solvation energy calculations and mechanistic studies on degradation pathways. Discovery support and formulation development, as described below. Formulation design and preparation for DMPK studies. -
Senior Research ScientistPfizer Oct 1993 - Jan 1997New York, New York, UsOral Drug Delivery: Early Candidates Group. Supervision of two laboratory assistants. Discovery support: physicochemical properties characterization (solubility, pKa, intestinal absorption rate constants), degradation studies, isolation and characterization of degradants. Computational chemistry: solvation energy calculations and mechanistic studies. Oral Dosage Forms Development: DMPK studies, drug safety evaluation studies, clinical studies for Phase I and early Phase II. Solutions and solid dosage forms development and stability studies. -
Senior Research ChemistMerck Nov 1990 - Sep 1993Pre-formulation work. HPLC analysis of drug concentration in formulations and in bulk. Stability analysis and kinetics in bulk and with excipients, physicochemical properties determination, thermal analysis, polymorphism.
Franco Lombardo Skills
Franco Lombardo Education Details
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University Of MinnesotaOrganic Chemistry -
Sapienza Università Di RomaPharmaceutical Chemistry
Frequently Asked Questions about Franco Lombardo
What company does Franco Lombardo work for?
Franco Lombardo works for University Of Minnesota
What is Franco Lombardo's role at the current company?
Franco Lombardo's current role is Adjunct Faculty.
What is Franco Lombardo's email address?
Franco Lombardo's email address is fr****@****mes.com
What is Franco Lombardo's direct phone number?
Franco Lombardo's direct phone number is (717)-228*****
What schools did Franco Lombardo attend?
Franco Lombardo attended University Of Minnesota, Sapienza Università Di Roma.
What skills is Franco Lombardo known for?
Franco Lombardo has skills like Adme, Oncology, Pharmacokinetics, Drug Design, Drug Discovery, Lead Optimization, Computational Chemistry, Medicinal Chemistry, Infectious Diseases, Drug Metabolism, Lead Change, Biotechnology.
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