Louise Klem Email & Phone Number

Copenhagen, Capital Region Of Denmark, Denmark

As of current, my position has expanded to acting as the Research Lead across different CNS indications (mainly neurodegeneration), supporting both preclinical and clinical development of novel therapies. In this capacity, I am developing our Parkinson’s Disease program and act as Principal Investigator on our associated project (MJFF-024128). This role also involves disseminating our science and research, incl. contributing to publications, e.g. a recent Drug Discovery article on New Frontiers in Parkinson’s Disease. Furthermore, I manage stakeholder relationships, incl. with management, CROs, KOLs, and collaborators. I lead a team of scientists, and together we review literature, plan PK/PD and disease model experiments (both in vivo and in vitro, e.g. iPSC work), and provide data management, analysis, and interpretation. The team also writes grant applications to ensure research funding.

Copenhagen, Capital Region, Denmark

My role was expanded to involve additional projects and more direct responsibility for stakeholder management.

Copenhagen, Capital Region, Denmark

I support the preclinical development of novel therapies to address unmet needs within neurodegenerative diseases. My tasks include reviewing literature, planning PK/PD and disease model experiments, and providing data management, analysis, and interpretation.

Copenhagen, Capital Region, Denmark

I worked on fixed-term projects at Lundbeck across different departments, including on a research project investigating in vitro alternatives to a cytotoxicity assay and an in vivo skin irritation assay. The aim of this project was to improve animal welfare and potentially increase the predictive capabilities of the animal models and experiments. I also organised a vehicle database, to provide an overview of the toxicological data.

Copenhagen

This research project examines pharmacological and chemogenetic interventions in the rodent continuous performance test, to assess the impact of dopamine and noradrenaline on attention and impulsivity. We also examine the contribution of different neurotransmitter receptor families towards the therapeutic effects of ADHD medications.I have also had the pleasure of supervising several master students over the years, who contributed to the project.Main Supervisor: Associate Professor Jesper T. Andreasen, PhDCo-supervisor: Assistant Professor Andreas T. Sørensen, PhDCo-supervisor: Associate Professor David P. D. Woldbye, PhD, MD

This research project explored the use of gene therapy as an emerging treatment strategy for pharmaco-resistant epilepsy, affecting 30-40% of epilepsy patients. Therapeutic transgene overexpression was mediated through adeno-associated viral vectors delivered to the rodent hippocampus through stereotaxic surgery. The seizure-suppressant effects were examined in a kainic acid seizure model, with side effects on memory assessed in the Morris water maze and Y maze for spontaneous alternation. Viral vector expression was examined through immunohistochemistry staining and the quantitative polymerase chain reaction assay.Supervisor: Associate Professor David P. D. Woldbye, PhD, MD

Hillerød

This was a fixed-term internship in Hemophilia Factor Vlll treatment in Biopharm, Novo Nordisk. I supported the development and implementation of a new IT-based production planning system (Access Orchestrate), in order to optimise resources, prevent scheduling errors, and minimise waste. In this regard, I was very fortunate to collaborate with several different parties to collect different input for the functionality of the new system. I also developed educational material and held instructional sessions on the topic of the new planning system.Furthermore, I participated in the development of cLEAN systems to identify error types and solutions, which further supported the department's goal of minimising flaws within API production.

Københavnsområdet, Danmark

While still maintaining my responsibilities as Translator/Proofreader, I was promoted to Assistant at Labster. In this context, I was tasked with researching potential candidates for available positions, coordinating and managing special projects, and assisting with various assignments.

Copenhagen

In this context, I have had the pleasure of working with Labster's virtual laboratories. These are aimed at the betterment of E-learning within STEM-pathways of education. My main function at Labster has been proofreading and bugtesting both Danish and English virtual laboratories. In this regard, I have also assisted with translation of the English laboratories to Danish and vice versa.

Phd, Neuropharmacology

Msc Pharmaceutical Sciences, Drug Discovery

Bachelor Of Pharmacy

Biology A, Physical Education B, Mathematics B.

Supplementary levels of Mathematics A and Physics B were achieved at Voksen Uddannelsescenter Frederiksberg (VUF).