Luca Settimo Email and Phone Number
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I am a Pharmaceutical Professional with experience both in clinical and pre-clinical research.I have in fact worked in different roles (such as Mental Health, Clinical Trials, Clinical research - with a special interest in population PKPD modeling and dose predictions) and also an experienced computational chemist (having worked in different pre-clinical research projects). My interests:► Psychiatric medicine; ► Clinical trials;► Pharmacometrics, PKPD and PBPK modelling;► Drug dosing prediction and optimization using computational methods;► Pharmacology, evidence-based medicine and clinical pharmacy;► absorption-distribution-metabolism-toxicity (ADMET) studies of drugs;► Knowledge extraction form large amount of data using different statistical tools;► Application of in silico methodologies for drug discovery: protein-structure based drug design (homology modeling, molecular docking, molecular dynamics simulations); ligand-based methods (e.g. SAR and pharmacophore modeling); QM calculations; metabolism and tox predictions; I have directly contributed to several programs across multiple disease areas. I have in-depth experience of working both within academia, hospitals as well as different pharmaceutical industries resulting in several scientific contributions (more than twenty scientific articles/patents/scientific posters/oral communications presented to the scientific community).Additionally, from 2015 I have been studying Philosophy and Theology (obtaining both a MA in Systematic and Philosophical Theology in 2019 and a PhD in Theology in 2022). I am particularly interested in the theological engagement with the latest scientific research in the field of psychiatry. From December 2022 I have been conferred the title of Honorary Post-Doctoral Fellow in Theology at the University of Nottingham. For more information on my philosophical-theological studies see:https://www.nottingham.ac.uk/Humanities/Departments/Philosophy/People/luca.settimo1
University Of Nottingham
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Honorary Post-Doctoral Fellow (Theology)University Of NottinghamUnited Kingdom
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Pharmaceutical Professional (Hospital Clinical Pharmacist)Nhs (As Contractor) Apr 2019 - PresentEnglandI continue to offer my skills as Hospital Clinical Pharmacist (as I did in the my previous roles - but now as Mental Health Pharmacist) for the NHS given my recent specialisation in pharmaceutical sciences tailored for Psychiatric medicine.From April 2019 I offer this service to the NHS as contractor (rather than as employee of the NHS).I am interested to many aspects of academic research in relation to pharmaceutical sciences (from the design of new molecules, to the development of drugs from the pre-clinical studies to the different clinical phases) especially the aspect related to PKPD. A satisfactory aspect of my work has been the ability to witness the clinical effect of medications in helping patients in the clinical settings where I work.
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Hospital Clinical PharmacistNhs Jan 2014 - Apr 2019England, UkFrom January 2014 until April 2019 I have been employed by three different NHS Trust in England as Hospital Clinical Pharmacist.In this period, I have covered different roles.From September 2017 to April 2019, I have worked as Clinical Trials and Research Pharmacist with the following responsibilities:• Ensuring implementation of good clinical practice guidelines (GCP) for all clinical trials running in the hospital• Feasibility assessments, contracts and hosted and sponsored studies• Review clinical trial proposals to ensure that all information is available, feasible andcorrect in terms of clinical, technical and dispensary information and documentation.• Work with Trust Research and Development, Sponsors to resolve issues identified in review of clinical trials• Be aware of and keep knowledge up to date of all policies, protocols, standards and guidelinesrelated to Pharmacy and IMP management.• Undertake teaching and training sessions to nursing, medical and pharmacy staff as required.I have been the responsible pharmacist for more than 100 clinical trials in an hospital (see e.g. the acknowledgement in the following clinical trial: https://www.ncbi.nlm.nih.gov/books/NBK563841/ )In addition, I have worked in the field of drug dosing predictions using PKPD modelling (e.g. for dose adjustments in patients with low eGFR), therapeutic drug monitoring, and evidence based medicine.See e.g. my work published in Journal of Psychopharmacology (2018), 32, pp. 96–104. See also: https://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/fd6dc9ea-ceb7-4906-aa9a-81a9df4647a5I also supervised a master student at the department of Pharmacy (University of Reading):Title of the thesis: "Assessing and comparing the accuracy of three PK models in predicting serum lithium level concentrations giving consideration to influencing factors with the aim of reducing the incidence of lithium-induced renal toxicity".
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Honorary Research Fellow (Computational Chemist)The University Of Glasgow Jan 2014 - Jan 2019College Of Medical, Veterinary And Life SciencesComputational chemist at the Institute of Immunology, Infection and Inflammation. Successfully published four scientific articles (listed in the "publications" section in my linkedin profile below) and two scientific oral communications. -
Adjunct Research Scientist (Computational Chemist)Northeastern University Dec 2012 - Apr 2016Computational chemist working in the field of neglected tropical diseases. Successfully published two scientific papers (listed in the "publications" section in my linkedin profile below) and two scientific posters in two different conferences. -
Hospital Clinical PharmacistNuffield Health Jul 2013 - Jan 2014Manor Hospital, OxfordExpert in oncology clinical pharmacy (implementation of different Thames Valley Cancer Network protocols for patients in the hospital). Dose predictions in different patients considering renal clearance and other parameters. -
Computational ChemistVertex Pharmaceuticals Jan 2007 - Aug 2012Abingdon, Oxfordshire, Uk• Responsible for a number of significant computer-assisted drug design projects in different disease areas (using a combination of methods such as homology modeling, molecular docking, different QM techniques, virtual screening, molecular dynamics simulations, pharmacophore modelling). • Expert in kinase modeling, the application of which led to the publication of three scientific articles and different patents (listed in the "publications" and "patents" sections in my linkedin profile below). • Recognised by the business for the implementation of different computational tools in a web-based platform allowing chemists to (i) run different in silico predictions on chemical compounds and (ii) easily use molecular docking to speed up protein-structure ligand design.• Experienced in ADMET and DMPK issues assisted in many pre-clinical drug development studies that minimised the risk of project failure. • Applied in depth knowledge of in silico toxicity and drug safety predictions (which included identification and study of toxicophores and reactive metabolites from the literature) that resulted in the creation of a database to help to predict toxicity, one scientific article two key note presentations that I delivered in two different conferences:- "Predicting hERG liabilities using different in-silico methods" at the smi conference “ADMET”, London, 9-10 July 2012 - "Lessons learnt in predicting hERG liabilities using different in-silico methods" at the smi conference “Advances and Pogress in Drug Design”, London, 20-22 February 2012 -
Computational ChemistDompe' Pharmaceuticals Jan 2006 - Dec 2006L’Aquila Area, Italy• Applied Computer-Assisted Drug Design expertise to a number of G-protein coupled receptors (GPCR) modelling projects. Results of which led to the publication of two scientific posters:Beccari, A.R., Moriconi, A., Trombetta, S., Aramini, A., Settimo, L., Rossi, I. Fariselli,P., Pugliese, L., Allegretti, A. GPCRBASE: A Knowledge Base System for DrugDiscovery, poster presented at the 16th European Symposium on Quantitative Structure-Activity Relationships and Molecular Modelling, September 2006 (cruise mediterraneansea)Genovese, F., Aramini, A., Colagiola, S., Amore, A., Cesta, M.C., Nano, G., Settimo, L.,Palmieri, E., Allegretti, M. Interleukin-8 inhibitors lead optimisation studies: mechanismof action and chemoselective functionalisation of hydroxyalkylphenols, poster presentedat the IASOC 06, Ischia Advanced School of Organic Chemistry, Ischia, September2006 (Naples, Italy)
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Doctoral And Postdoctoral Researcher ScientistStructural Bioinformatics Laboratory Jan 2000 - Jan 2006Department Of Biochemistry And Pharmacy, Åbo Akademi University (Turku, Finland)• Acquired leading edge techniques in the structural bioinformatics and computational chemistry field.• Focused on the in silico study of protein-ligand interactions in the Ionotropic Glutamate Receptors.• Personally established the “Erasmus” exchange programme between Padova University and Åbo Akademi University thereby allowing exchange of researchers between the two universities and significantly increasing opportunities to share and apply research knowledge.• Successfully published nine scientific papers, one scientific monograph (listed in the "publications" section in my linkedin profile below) and more than fifteen scientific posters/key note presentations in different conferences.
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ConsultantFatman Bioinformational Design Ltd Jan 2001 - Dec 2001Turku, Finland• Applied Computer-Assisted Drug Design expertise to a number of drug discovery projects.
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Postgraduate Researcher ScientistCribi Biotechnology Center (University Of Padova, Italy) May 1999 - Oct 1999Padova Area, Italy• Expert in the following methodologies: solid phase peptide synthesis (SPPS); MALDI-TOF; different chromatographic techniques and spectroscopic techniques such as CD spectroscopy. Research focussed on synthesis and structural studies of a synthetic fragment of calmodulin. Part of this work led to the publication of two scientific papers (listed in the "publications" section in my linkedin profile below) and three scientific posters/key note presentations in different conferences.
Luca Settimo Skills
Luca Settimo Education Details
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Phd In Theology
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With Distinction
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With Merit -
Pharmacy -
Åbo Akademi UniversityStructural Bioinformatics And Computational Chemistry -
University Of PadovaQualification To Work As A Pharmacist In The European Union
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University Of PadovaMedicinal Chemistry And Pharmaceutical Technology
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Istituto Tecnico Industriale Statale G. NattaIndustrial Chemistry High School Degree
Frequently Asked Questions about Luca Settimo
What company does Luca Settimo work for?
Luca Settimo works for University Of Nottingham
What is Luca Settimo's role at the current company?
Luca Settimo's current role is Honorary Post-Doctoral Fellow (Theology).
What is Luca Settimo's email address?
Luca Settimo's email address is ls****@****o.co.uk
What schools did Luca Settimo attend?
Luca Settimo attended University Of Nottingham, University Of Nottingham, Aston University, The University Of Manchester, Åbo Akademi University, University Of Padova, University Of Padova, Istituto Tecnico Industriale Statale G. Natta.
What are some of Luca Settimo's interests?
Luca Settimo has interest in Swimming, Philosophy, Health.
What skills is Luca Settimo known for?
Luca Settimo has skills like Clinical Trials, Hospital Pharmacy, Pharmacy, Adme.
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