Luca Tottone, Phd
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Luca Tottone, Phd Email & Phone Number

Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery at AstraZeneca
Location: Miami, Florida, United States 4 work roles 3 schools
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Current company
AstraZeneca
Role
Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery
Location
Miami, Florida, United States
Company size
78605 employees

Who is Luca Tottone, Phd? Overview

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Quick answer

Luca Tottone, Phd is listed as Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery at AstraZeneca, a company with 78605 employees, based in Miami, Florida, United States. AeroLeads shows a matched LinkedIn profile for Luca Tottone, Phd.

Luca Tottone, Phd previously worked as Assistant Scientist at Sylvester Comprehensive Cancer Center and Postdoctoral Researcher at Rutgers Cancer Institute Of New Jersey. Luca Tottone, Phd holds Doctor Of Philosophy - Phd, Molecular Medicine, Phd With Honors from Sapienza Università Di Roma.

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AstraZeneca

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About Luca Tottone, Phd

PhD Scientist with 10+ years of hands-on research proficiency in hematology, blood malignancies, and leukemia therapeutics. Conducted independent in vivo and in vitro translational studies focused on preclinical cancer targeting and drug discovery.Critical thinker capable in managing complex scientific programs with excellent track record of scientific achievements: Authored 8 scientific articles with 300+ Citations (Blood Cancer Discov, Nat. Commun., Scientific reports…). International patent deposit for novel small molecule drugs with anti-leukemic activity (US11104657B2). Filed and won several state, national, and private research funds (fellowships and grants) for a total of $250k. Invited speaker for oral presentations at several national meetings (FASEB Outstanding Abstract Award). Liaised with international renown experts in the field of cancer genomics (St. Jude Hospital and Columbia Uni.).Technical skills: Expert in in vivo/in vitro disease and mechanistic modeling, with focus on T-cell and myeloid leukemias therapeutics.  In vivo modeling of tumor generation, bone marrow transplants, PDXs, in vivo treatment, tissue sampling, necroscopy. Gene editing expertise via viral and RNP gene transduction, RNAi, gene overexpression, gene silencing, CRISPR/Cas9. Expertness in cell-based techniques, primary human samples isolation, cell culturing, aseptic techniques, drug testing.  NGS assays (RNA-Seq, scRNA-Seq, ChIP-Seq), RNA assays (qPCR), DNA assays (PCR, ChIP), Protein assays (IP, WB), Flow cytometry.

Current workplace

Luca Tottone, Phd's current company

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AstraZeneca
Astrazeneca
Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery
Waltham, MA, US
Website
astrazeneca.com
Employees
78605
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4 roles

Luca Tottone, Phd work experience

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Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery

Astrazeneca

Waltham, MA, US

Assistant Scientist

Current
Sylvester Comprehensive Cancer Center

Miami-Dade County, Florida, United States

Senior Scientist focused on describing the epigenetic and transcriptional mechanisms that characterize both the physiological differentiation of myeloid lineage and the pathological transformation of myeloid precursors into Acute Myeloid Leukemia (AML).

May 2022 - Present

Postdoctoral Researcher

Rutgers Cancer Institute Of New Jersey

New Brunswick, New Jersey, United States

Postdoctoral fellow dissecting the epigenetic modifications that affect T-Cell Acute Lymphoblastic Leukemia (T-ALL) onset and resistance to therapies.By mastering state-of-the-art techniques in genome analysis, I identified a tumor suppressor enhancer of PTEN in T-ALL (PE) located ~550Kb downstream to the gene TSS. PE shows high levels of interaction with.

Mar 2018 - May 2022

Research Scientist

Istituto Italiano Di Tecnologia

Rome, Latium, Italy

Leukemia specialist involved in the identification of novel inhibitors of the oncogene NOTCH1.Starting from an in-house library of natural molecules, I screened, identified and refined Compound 8 (C8), a chalcone derivative showing potent anti-leukemic and Notch inhibitory activity at low micro molar concentration.Notably, this research led to a.

Oct 2016 - Mar 2018
Team & coworkers

Colleagues at AstraZeneca

Other employees you can reach at astrazeneca.com. View company contacts for 78605 employees →

EA Elisa Agate Elisa Agate Colleague at AstrazenecaLondon, England, United Kingdom, United Kingdom View → CT Camille Taupy Camille Taupy Colleague at AstrazenecaFrance, France View → FM Fintan Mckearney Fintan Mckearney Colleague at AstrazenecaDublin, County Dublin, Ireland, Ireland View → TL Tove Lindholm Tove Lindholm Colleague at AstrazenecaNykvarn, Stockholm County, Sweden, Sweden View → MM Monique Mulder Monique Mulder Colleague at AstrazenecaAustria, Austria View → PP Punit Paruthi Punit Paruthi Colleague at AstrazenecaUnited Kingdom, United Kingdom View → AA Aseel Alshahrani Aseel Alshahrani Colleague at AstrazenecaAsir Region, Saudi Arabia View → JG Julie Genchel Julie Genchel Colleague at AstrazenecaStockholm, Stockholm County, Sweden, Sweden View → YB Yvonne Bertlin Yvonne Bertlin Colleague at AstrazenecaSweden, Sweden View → PT Pranav Tharan Pranav Tharan Colleague at AstrazenecaChennai, Tamil Nadu, India, India View →
3 education records

Luca Tottone, Phd education

Doctor Of Philosophy - Phd, Molecular Medicine, Phd With Honors

Sapienza Università Di Roma

PhD candidate involved in the identification of the mechanisms driving aberrant Notch3 expression in acute lymphoblastic leukemia. My PhD.

Master'S Degree, Molecular Medicine, 110 Cum Laude

Sapienza Università Di Roma

Me and my former colleagues described the oncogenic role of miR-223 in T-ALL development, demonstrating that the over-expression of this.

FAQ

Frequently asked questions about Luca Tottone, Phd

Quick answers generated from the profile data available on this page.

What company does Luca Tottone, Phd work for?

Luca Tottone, Phd works for AstraZeneca.

What is Luca Tottone, Phd's role at AstraZeneca?

Luca Tottone, Phd is listed as Senior Scientist, In Vivo Pharmacology, Hematology Oncology Targeted Discovery at AstraZeneca.

Where is Luca Tottone, Phd based?

Luca Tottone, Phd is based in Miami, Florida, United States while working with AstraZeneca.

What companies has Luca Tottone, Phd worked for?

Luca Tottone, Phd has worked for Astrazeneca, Sylvester Comprehensive Cancer Center, Rutgers Cancer Institute Of New Jersey, and Istituto Italiano Di Tecnologia.

Who are Luca Tottone, Phd's colleagues at AstraZeneca?

Luca Tottone, Phd's colleagues at AstraZeneca include Elisa Agate, Camille Taupy, Fintan Mckearney, Tove Lindholm, and Monique Mulder.

How can I contact Luca Tottone, Phd?

You can use AeroLeads to view verified contact signals for Luca Tottone, Phd at AstraZeneca, including work email, phone, and LinkedIn data when available.

What schools did Luca Tottone, Phd attend?

Luca Tottone, Phd holds Doctor Of Philosophy - Phd, Molecular Medicine, Phd With Honors from Sapienza Università Di Roma.

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