Luke Ward Email & Phone Number

Cambridge, Massachusetts, Us

Cambridge, Massachusetts, Us

Cambridge, Massachusetts, Us

Statistical genetics for discovery, program, and product support

Thousand Oaks, Ca, Us

• Providing interpretation and analysis of human genetics data for target characterization, validation, and issue resolution at all stages of Amgen's pipeline (discovery, preclinical, clinical, and postmarketing)• Leading efforts to incorporate genetics into interpretation of pharmacovigilance safety signals• Collaborating with outside investigators on several pharmacogenetics studies of adverse drug events• Coordinating toxicogenomics assays and computational support for other projects involving in-house RNA-Seq data• Advancing the science of using human genetics in drug safety by publishing retrospective analyses• Contributing as a computational biologist to a wide array of projects in a mechanistic and predictive toxicology group using iPSCs and other in vitro models of human systems• Systematically integrating GWAS and PheWAS to de-risk and prioritize the early pipeline

Reykjavík, Capital Region, Is

• Annotated noncoding SNPs to translate GWAS associations to biological insights• Performed PheWAS on drug target genes to generate drug safety predictions

Bethesda, Md, Us

Provided contract biomedical informatics consulting for three clients:• Performed bioinformatics requirements analysis and UI design for a web-based oncology clinical trial exchange• Created a model to forecast clinical trial recruitment for a pharmaceutical company and provided competitive intelligence research• Served as a data scientist for a pharmaceutical company developing a clinical trial data management solution

Cambridge, Ma, Us

Cambridge, Ma, Us

Research in human regulatory genomics:• Conceived and performed integrative analyses of human functional, comparative, and population genomics data to interpret genome-wide association studies and evolutionary signatures, contributing to 14 peer-reviewed publications (four as first author)• Served as an analyst in the ENCODE, Roadmap Epigenomics, GTEx, and 29 Mammals projects• Built and maintained a popular web database, HaploReg, for systematic interpretation of disease-associated common variation (as of 2021: 104k unique visitors; 2,451 citations)• Assisted in writing and preparation of successful NIH grants• Supervised six students (undergraduate, masters, and doctoral) in a large, dynamic research group• Mentored a high school student whose project was selected as Intel Semifinalist (MIT PRIMES Program), 2013-2014• Designed the syllabus and programming exercises for a new seminar in personal genomics (6.881), 2012

Cambridge, Ma, Us

Since 2011 I have maintained and supported HaploReg, a database for GWAS SNP annotation.

New York, Ny, Us

Lab of Harmen Bussemaker. Research in regulatory genomics of model organisms:• Studied the interplay between sequence, chromatin, and gene expression in yeast and fly using computational tools, contributing to six peer-reviewed publications (two as first author)• Led discussion sections and programming tutorials for two systems biology courses at Columbia and a summer course at Cold Spring Harbor Laboratory• Served as section head for a summer fellowship program for undergraduates, designing and leading group sessions on reading the literature, statistics, and presentation (SURF Program and Amgen Scholars Program), 2006-2007• Designed and delivered lectures and problem sets for a summer physics course for premeds (Robert Wood Johnson Foundation SMDEP Program), 2008-2009• Rotation bench work performing C. elegans genetics in a developmental biology lab and organic synthesis in a chemical biology lab

New York, Ny, Us

Lab of Joel Belasco. Performed RNA-binding assays to ensure that a variant of HIV-1 Rev protein being used for structural studies retained its function.

Charlottesville, Virginia, Us

Lab of Ann Beyer. Performed cytological studies to visualize hnRNP-chromatin interactions in D. melanogaster.

Gaithersburg, Md, Us

Lab of Gary Gilliland. Performed crystallization screens on "hypothetical proteins" cloned from H. influenzae as part of a structural genomics initiative.

Washington, Dc, Us

Lab of Matt Mauro. Cloned and purified a variant E. coli thioesterase to be used in nanovesicle engineering.

New London, Ct, Us

Lab of Bruce Branchini. Performed site-directed mutagenesis on P. pyralis firefly luciferase to support structure-function studies of its bioluminescence.

Doctor Of Philosophy (Ph.D.), Biological Sciences

Bachelor Of Science (B.S.), Chemistry And Music

Education record