Luis A. Lopez Email and Phone Number
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Loyal and dependable talented Scientist with a proven track record for delivery of high quality compounds for pre-clinical evaluation through both judicious physical property and SAR-based optimization. Drove support of multiple project-teams objectives through synthesis of multigram quantities (up to 500g) of lead compounds in a time-constrained fashion for key proof of concept and toxicity studies.• Design and execute syntheses of complex organic molecules.• In-depth knowledge of advanced synthesis including heterocyclic chemistry, metal catalyzed reactions, air-sensitive protocols, and complex multi-step syntheses.• Extensive expertise in purification and spectroscopic techniques utilized in the preparation and characterization of complex organic molecules (NMR, LC-MS, HPLC, etc.).• Effectively works in teams and collaborates with other scientists including biologists, pharmacologists and toxicologists.• Involved in the management and day-to-day running of a chemistry lab.
Plexium
View- Website:
- plexium.com
- Employees:
- 44
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ScientistPlexium Aug 2021 - PresentSan Diego, California, United States -
ScientistGossamer Bio Oct 2018 - Jul 2021Greater San Diego Area -
Associate ScientistAvisyn Pharma Oct 2016 - Sep 2018Greater San Diego Area• Avisyn provides in-house staffing solutions (insourcing) for drug discovery R&D and drug development. As a process chemist embedded with a project team, I work alongside the client's scientists and senior associates, supporting various aspects of process research and development of lead compounds.
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Contractor (Avisyn Pharma)Dart Neuroscience 2016 - 2017Greater San Diego Area• Developed synthetic routes utilizing scientific and technical information found in literature.• Optimized the synthetic route for an Active Pharmaceutical Ingredient (API) that will be applied to the future GMP manufacture of the drug substance.• Successfully demonstrated key synthetic modifications to the manufacturing process of a Phase 2 clinical candidate.• Use of/familiarization with analytical techniques DSC, TGA, XRPD.• Identified and synthesized LC/MS markers and impurities of an API manufacturing campaign.• Proficient use of vertical reactors to mimic ‘plant-like’ manufacturing conditions and optimize chemistry.• Technology transfer of synthetic routes to contract manufacturing organizations (CMOs).• Partnerships with CMOs to manufacture multi-kilogram quantities of API for toxicological and clinical batches.
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Scientist IiArena Pharmaceuticals 2014 - Aug 2016Greater San Diego Area• Prepared high quality compounds by interpreting the SAR and identifying lead compounds with desirable selectivity and DMPK characteristics which led to a collaboration with Boehringer Ingelheim.• Initiated trial of flow chemistry hydrogenation (H-Cube) for the department, which subsequently demonstrated clear advantages in terms of faster reaction times, reduced solvent waste, and enhanced reaction safety leading to investment and wide uptake in this technology.• Responsible for safe operation and upkeep of hydrogenation equipment. Carried out routine maintenance of lyophilizer and vacuum pumps enabling continuous operation leading to operational cost savings. -
Scientist IArena Pharmaceuticals 2010 - 2014Greater San Diego Area• Synthesized key building blocks to support multiple medicinal chemistry campaigns.• Investigated, created and developed new synthetic methodology and technical improvements that led to process routes for Ralinepag and Etrasimod two compounds currently in phase II clinical trials.• Worked on a wide variety of small molecule projects from early hit-to-lead to late lead optimization.• Appointed safety officer for laboratory. Organized and maintained laboratory for maximum productivity and safety. -
Associate ScientistArena Pharmaceuticals 2007 - 2010Greater San Diego Area• Synthesized multigrams of a key compound that ultimately led to the discovery and nomination of Etrasimod (APD334) as a next generation, highly specific modulator of the sphingosine 1-phosphate receptor (currently in phase II clinical trials).• Designed, synthesized novel bioactive molecules for the discovery of a chemically unique backup compound to Etrasimod.• Collaborated in the development and scale-up of a enantiospecific synthesis for a backup compound to Etrasimod. -
Senior Research AssociateArena Pharmaceuticals 2006 - 2007Greater San Diego Area• Employed parallel synthetic techniques to rapidly advance med chem objectives.• Prepared multigrams of key building block used to make multiple compounds in parallel.• Developed chiral HPLC methods to separate key compounds for S1P1 receptor.• Communicated results to co-workers and management in both oral and written manner and assisted in the preparation of patent applications.• Summarized and presented work at bi-weekly group meetings. -
Senior Production Chemist IiPfizer Pharmaceuticals 2003 - 2006Greater San Diego Area• Assisted in implementing innovative glove box technology and utilized this technology to ensure stringent conditions for sensitive metallation reactions.• Synthesized a wide range of quality organic compounds by applying structure-based drug design principles for potential drug candidate by implementing new innovative combinatorial chemistry technology. -
Senior Production Chemist IPfizer Pharmaceuticals 2001 - 2003Greater San Diego Area• Carried out synthetic procedures for all libraries concerning production of small molecules.• Maintained all laboratory equipment, updated hardware and software applications for run compatibility in compliance with company protocols. -
Research Associate IiPfizer Pharmaceuticals 1999 - 2001Greater San Diego Area• Trained 12 non chemists to work in a production lab and make over 20,000 compounds a year.• Properly programmed and operated lab equipments such as multiprobe robotic liquid handler. -
Research Associate IPfizer Pharmaceuticals 1997 - 1999Greater San Diego Area• Developed optimal conditions for yield and purity in multi-step, multi-component reactions. (solvent, temperature, time, concentration, base and reactant scope studied).• Wrote procedures and protocols to be used in preparing exploratory and targeted compound libraries throughout multiple Pfizer sites. -
Qa TechnicianSafeskin Corporation 1996 - 1997Greater San Diego Area• Assisted in establishing Quality Assurance Laboratory for Forbes No. 1 Small Company for 1996.• Helped in designing, development and implementation of a Microsoft ACCESS database system that encompassed retrieval of laboratory data and analysis of such data.• Assured the quality of new batches of surgical gloves met ISO 9000 quality standard
Luis A. Lopez Skills
Luis A. Lopez Education Details
Frequently Asked Questions about Luis A. Lopez
What company does Luis A. Lopez work for?
Luis A. Lopez works for Plexium
What is Luis A. Lopez's role at the current company?
Luis A. Lopez's current role is Scientist at Plexium.
What is Luis A. Lopez's email address?
Luis A. Lopez's email address is lu****@****bio.com
What schools did Luis A. Lopez attend?
Luis A. Lopez attended California Polytechnic State University-San Luis Obispo.
What skills is Luis A. Lopez known for?
Luis A. Lopez has skills like Medicinal Chemistry, Organic Synthesis, Drug Discovery, Chemistry, Organic Chemistry, Drug Design, Chromatography, Purification, Parallel Synthesis, Biotechnology, Hplc, Lc Ms.
Who are Luis A. Lopez's colleagues?
Luis A. Lopez's colleagues are Suzanne Zoumaras, Gabrielle Blanco, Taylor Kampert, Ryan Cecil, Kyohei Hayashi, Vincent Aguilar, Titi Budhisetiawan.
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