Lukasz Jaremko Email and Phone Number

Leader of Molecular Diagnostics and Drug Discovery (MD3) Lab The lab page: https://md3.kaust.edu.sa/Research in Molecular Diagnostics and Drug Discovery (MD3) group focuses on atomic-level insight into essential and topical questions from biochemistry and medicine, such as, e.g., the primary molecular bases of cancer, including leukaemia and lung cancer (Nature, 2021). The team is actively working on targeted drug design and discovery, using innovative structure-dynamics analysis to search for small molecules (ligands) that interact specifically with the disease-associated proteins (Nature Communications 2022; Structure 2023). Identified lead compounds are engineered to increase their binding and, thus, therapeutic potency against cancer (Nature Chem Biol, 2021). Biomolecular nuclear magnetic resonance (NMR) spectroscopy is the crucial experimental technique used and refined (J Chem Phys B, 2015; Angewandte Chem, 2016; J Biomol NMR, 2018, 2020) to tackle challenging macromolecular assemblies (Nature Chem Biol, 2013, 2021; Science, 2014; Nature Communications, 2016, 2017, 2022; Nucleic Acids Res, 2019; Am J Hum Genetics, 2019; Chemical Science, 2020; eLife, 2021; Nature 2021; Mol. Cell 2021; Structure 2023). The MD3's integrative structural studies by NMR, X-ray crystallography and cryo-EM are combined with molecular and enzymatic assays, other state-of-the-art biophysical techniques, and molecular dynamics simulations to get further insights into the complex biological systems essential for human health.