The role of the parenterals team in Product Development is to design and develop the formulation, process and analytical methods for new drug products.• Lead process engineer on 3 different sterile drug product processes. Responsible for planning and optimising small-scale processes and scaling for clinical manufacture and commercial launch 1) Oligonucleotide during commercialisation, in-licenced from an external partner: authoring sections of the commercial submission… Show more The role of the parenterals team in Product Development is to design and develop the formulation, process and analytical methods for new drug products.• Lead process engineer on 3 different sterile drug product processes. Responsible for planning and optimising small-scale processes and scaling for clinical manufacture and commercial launch 1) Oligonucleotide during commercialisation, in-licenced from an external partner: authoring sections of the commercial submission within extremely tight timelines and proactively identifying and planning scale up requirements 2) Oligonucleotide in development: leading technology transfer onto a new manufacturing fill-line at contract manufacturing organisation and leading the completion of the quality risk assessment 3) Polymeric nanoparticle, manufactured by a very complex sterile method: responsible for process scale up, technology transfer of a lyophilisation process, optimisation of emulsification and tangential flow filtration unit operations and response to regulatory questions• Led the multidisciplinary drug product delivery team on 2 different projects• Regular coaching of early career graduate engineers, helping them to shape their goals and personal development plans• Supervised multiple placement students and graduates, including training on equipment and processes, planning and execution of work, providing feedback and support through regular meetings• Leading a future facing technology excellence group assessing unit operations and process equipment for potential use in future projects• Trained as SHE and CoSHH risk assessor, completing assessments for the department• Subject matter expert for container closure integrity testing technology strategy, leading purchase, installation and preparation for the GMP qualification of new equipment Show less

The role of the parenterals team in Product Development is to design and develop the formulation, process and analytical methods for new drug products.• Provided engineering support on several different projects, including a paediatric oral solid dosage form, oligonucleotides and a nanoparticle• Supervision of 2 process engineering placement year students, providing day-to-day management, support and personal development guidance• Played a leading role in the organisation of an… Show more The role of the parenterals team in Product Development is to design and develop the formulation, process and analytical methods for new drug products.• Provided engineering support on several different projects, including a paediatric oral solid dosage form, oligonucleotides and a nanoparticle• Supervision of 2 process engineering placement year students, providing day-to-day management, support and personal development guidance• Played a leading role in the organisation of an internal conference for AstraZeneca process engineers from around the world• Completed a week-long detailed sterile manufacturing and aseptic processing training course Show less

The Pharmaceutical Technology & Development Graduate Programme involves three 8-month rotations across multiple functions at AstraZeneca, and offers personal development modules and invaluable insights to the drug development process and the commercialization of drug products

Operations 2020 is a large change programme, made up of more than 30 initiatives to improve all parts of the Global Operations organisation, touching all functions in Global Operations and more than 13 000 people.• Project managed the culture initiative, working with senior stakeholders to drive forward the vision of a workforce engaged with the company values and behaviours • Designed and delivered survey to ~4000 employees to check the progress and perception of… Show more Operations 2020 is a large change programme, made up of more than 30 initiatives to improve all parts of the Global Operations organisation, touching all functions in Global Operations and more than 13 000 people.• Project managed the culture initiative, working with senior stakeholders to drive forward the vision of a workforce engaged with the company values and behaviours • Designed and delivered survey to ~4000 employees to check the progress and perception of programme• Contributed to the planning and implementation of DAI decision making tool within Global Operations• Produced and delivered a global, multi-site communications campaign to reinforce the company values and prioritised behaviours• Created a change management framework to help the whole organisation better manage change Show less

Developed the continuous crystallisation process using a number of different API, improving AstraZeneca’s capability and understanding of this new, and very challenging process.• Developed the continuous crystallisation process successfully for 3 different APIs, discovering links between flowrate and particle properties • Contributed towards solving manufacturability issues with a marketed product, and challenged senior scientists on the conclusions being drawn from the… Show more Developed the continuous crystallisation process using a number of different API, improving AstraZeneca’s capability and understanding of this new, and very challenging process.• Developed the continuous crystallisation process successfully for 3 different APIs, discovering links between flowrate and particle properties • Contributed towards solving manufacturability issues with a marketed product, and challenged senior scientists on the conclusions being drawn from the data• Collaborated with CMAC, an industry-academia partnership, to design a set of experiments testing the capability of equipment, highlighted by completing these experiments at the University of Strathclyde Show less

The Advanced Packaging Design team are responsible for using predictive tools to gain insight into the stability and storage requirements of our products and to use that understanding to develop the correct packaging design.• Built capability by creating models to enable new stability prediction methods• Coordinated the packaging design for one particular product, acting as the packaging rep, preparing regulatory documents, using prediction tools, and facilitating meetings where the… Show more The Advanced Packaging Design team are responsible for using predictive tools to gain insight into the stability and storage requirements of our products and to use that understanding to develop the correct packaging design.• Built capability by creating models to enable new stability prediction methods• Coordinated the packaging design for one particular product, acting as the packaging rep, preparing regulatory documents, using prediction tools, and facilitating meetings where the designs were agreed• Upgraded a dissolution model to attempt to find links between storage conditions and dissolution• Discovered an opportunity to simplify and standardise a process and delivered the standardised solution Show less

Summer internship within the downstream team in Biotechnology and Environmental Shared Service department of GSK, working in the large scale laboratory, on the development of pharmaceutical processes.• Developed new processes, particularly focussed on liquid-liquid extraction • Improved existing processes, particularly focussed on Ultrafiltration• Designed safety features, such as guards, for the Ultrafiltration rig• Wrote a clear procedure detailing the use of the… Show more Summer internship within the downstream team in Biotechnology and Environmental Shared Service department of GSK, working in the large scale laboratory, on the development of pharmaceutical processes.• Developed new processes, particularly focussed on liquid-liquid extraction • Improved existing processes, particularly focussed on Ultrafiltration• Designed safety features, such as guards, for the Ultrafiltration rig• Wrote a clear procedure detailing the use of the Ultrafiltration rig to allow others to operate it correctly and safely Show less

Summer internship with 42 Technology, a technology consultancy, helping to solve issues with existing and new technology and products • Worked in teams to define, design, develop and deliver products and technologies• Worked within a laboratory setting• Used CAD to assist in the design of some products