Luo (Jack) Jia, Phd Email & Phone Number

Cambridge, MA, US

Waltham, Massachusetts, United States

• Lead the Disease Modeling Group in the development of preclinical animal models for autoimmune and allergic diseases.
• Collaborated closely with the business development team, spearheading scientific discussions with top biotech and pharma companies to secure projects, while also overseeing the design and execution of those projects.
• Managed the Biocytogen Boston site's autoimmune disease pharmacology portfolio, delivering products and services across multiple therapeutic areas, including Inflammatory Bowel Disease (IBD), Asthma, Atopic Dermatitis.

Cambridge, Massachusetts, United States

• Led immunology and organoid biology efforts in Ulcerative Colitis (UC) and Cirrhosis programs, aimed at developing microbiome-based therapeutics to enhance epithelial barrier function and immune response.
• Developed and optimized 2D/3D human primary organoid systems and epithelial barrier assays to study the mechanism of action (MoA) of candidate drugs, screening over 35 IBD donor microbiomes for pro-inflammatory bacteria.
• Performed transcriptome profiling of organoids under inflammatory conditions (IFNγ, TNFα) and tested interventions with designed human microbiome consortia.
• Analyzed RNA-seq data from UC patient colon biopsies (Phase II clinical study) to identify macrophage and neutrophil gene signatures, supporting patient population stratification efforts.
• Co-drafted serum cytokine biomarker strategies for the SER-155 Phase I study in collaboration with Memorial Sloan Kettering Cancer Center, targeting immunocompromised patients (allogeneic HSCT or solid organ.
• Led efforts from conceptualization through in vitro model development to full target validation, preparing IND filing for SER-147, a drug candidate aimed at infection protection in decompensated cirrhosis patients.

Newark, New Jersey, United States

Collaborated with Robert Wood Johnson Medical School gastroenterologists to isolate intraepithelial T lymphocytes in ileal biopsy from Crohn's Disease patients to perform single-cell RNA profiling.

Newark, New Jersey, United States

• Discovered microbiome-associated intestinal intraepithelial gamma delta (γδ) T cells, demonstrating their high proliferative and migratory properties in enhancing mucosal barrier protection.
• Identified that hyperproliferative γδ T cells significantly increased the metabolic profile, contributing to mucosal health.
• Developed an ex vivo murine organoid-γδ IEL (intraepithelial lymphocyte) co-culture model, revealing enhanced motility specifically within the Vγ1+ T cell subset.
• Established an in vitro T cell activation assay, showing that Type I IFN synergized with TCR activation to promote IFNγ production by γδ IELs.
• Secured $2 million in NIH R01 funding and a New Jersey Commission Cancer Research Grant for this project.
• Laid the groundwork for developing intraepithelial T lymphocyte-based therapies for Inflammatory Bowel Disease (IBD).

Newark, New Jersey, United States

Serve Chinese students and scholars to make a smooth transition in their study and work in Rutgers NJMS. CSSA also bridges the Chinese and other communities.

Guangzhou, Guangdong, China

Worked with clinician-scientists at department of surgery to investigate the mechanisms that M2 macrophages mediated TGF-b signaling promotes Wilms' tumor in children.1. Performed transcriptome analysis on tumor and control tissue. Validate results by RT-PCR.2. Conducted immunohistochemistry staining for M2 macrophages markers on 12 Formalin-Fixed.

Corvallis, Oregon, United States

Focused on immunological readout including mucosal immunoglobulin(Ig) T (functional equivalent to IgA in mammals ), systematic IgM, pro- and anti-inflammatory cytokines in a parasites co-infection model. Published in International Journal for Parasitology: Parasites and WildlifeCo-mentored by Dr. Jerri Batholomew and Dr. Brian Dolan.

Doctor Of Philosophy (Phd), Immunity, Infection And Inflammation

Master Of Science (Ms), Microbiology And Immunology（Focus Animal Medicine）

Immunoparasitology: • Development of monoclonal and polyclonal antibodies against Myxobolus honghuensis virulent structures: polar.

Bachelor’S Degree, Food Science And Engineering