Lin Yuan Email & Phone Number

Milpitas, Ca, Us

Milpitas, Ca, Us

Cambridge, Massachusetts, Us

Cambridge, Massachusetts, Us

Disease porgress model, Bayesian Statistics, Population PK/PD, Optimal Study Design1. Applied quantitative pharmacology approaches:•Applied adaptive Bayesian framework for clinical trial design of dose escalation.•Build a translational PKPD modeling with pre-clinical data of mRNA therapy to predict PKPD relationship in human.•Exposure analysis for trastuzumab administered for determined to therapies window. •Established a Bayesian approach for population PK/PD modeling.•MABEL Analysis by nonlinear mixed effects modeling of whole blood assay to determine of the starting dose in the first-in-human clinical trials.2. Developed platforms and software tools to help clients in screening•Use quantitative pharmacology approach (PKPD) to support the design an efficient screening strategy. •Design PDPK software tools for small molecules and large molecules in which they can quickly and easily generate basic PK and PKPD modeling assessments based on a limited set of (input) pre-clinical data.•Created Excel-based antibody optimization app with Python backend which is easily simulate drug-target kinetics, parameter sensitivity heatmaps and dose- response curve.3. Modeling to support Fractal grant concepts for SBIR/STTR grants:•Developed computational fluid dynamics (CFD) model for nasal spray of studied SARS-Cov. Help designing nasal spray solution to maximize the sprayed drug delivery at the nasopharynx.•Test efficacy of tumor-targeted bispecific antibody by simulating target occupancy.4. Modeling for basic science around SARS-CoV-2 (publications):•Build population PK modeling to predicting protection duration and half-life of natural immunity and vaccinal immunity of SAR-Cov.•Model-predicted lung pharmacokinetics for nebulized ribavirin to improve drug repurposing outcomes for inhaled COVID-19 therapeutics.

Tokyo, Jp

• Applied quantum chemistry theory to simulate molecular decomposition pathways and potential by-products for drug development hazard evaluation.• Software setup and programming support for LIGGGHTS (open-source DEM simulation software) related to chemical manufacturing of active pharmaceutical ingredients.• Simulated mass transfer and heat transfer process inside an agitated filter dryer (AFD) for drying process• Developed computational fluid dynamics (CFD) model for simulating gas transportation and liquid diffusion in reactors to help design a most effective process.• DEM simulation of Hardness test for tablet compression to determine the breaking point and structural integrity of a tablet, which could be used to establish a regulation.• Scale up batch reactor for mixing with gas mass transfer process

Tallahassee, Fl, Us

Performed Master's research work in Dr. Biwu Ma's group. My research focuses on the application and development of new functional materials with controlled chemical and physical properties. Developed a new kind of phosphorescent temperature and viscosity sensors by characterizing the materials properties. The materials under investigation range from organic compounds to metallo-organics, polymers, and organic/inorganic hybrids. The major purpose of my research is to study the underlying chemical and physical properties of new materials, and understand how molecular structure and processing conditions control the materials properties and affect their performance in devices. Due to the fundamental knowledge of the structure-property relationships, it allows for the further development and application of materials.

Assistant process engineer about project of alkane dehydrogenation process design. Data selection from PID and PFD.

Design of distillation column to separate ethanol and water. Computer simulation of refinery process.

Serve to students of chemical engineering department, planning and organizing students' activities such as festival galas and sport competitions.

Master’S Degree, Chemical Engineering

3+1 International Exchange Program, Chemical Engineering

Bachelor’S Degree, Chemical Engineering