Omid Madadgar Email & Phone Number

United States

East Lansing, Mi, Us

Bingham Farms, Michigan, Us

• Conducted comprehensive assessments of toxic doses for over 150 drugs and compounds, utilizing screening Beckman AU680 and confirmatory LC-MS tests to accurately detect and analyze patient samples.• Executed advanced analytical techniques including HPLC, LC-MS, and PCR to detect and quantify chemical and biological samples, ensuring precise and reliable results in toxicological investigations.• Managed the validation and accreditation processes for LC-MS and qPCR machines, including developing and implementing Standard Operating Procedures (SOPs), while maintaining compliance with the College of American Pathologists (CAP) standards.

East Lansing, Mi, Us

- Presented molecular mechanism of DNA damage and oxidative stress pathways of a vesicant toxin.-5 Peer-reviewed journal papers, 14 conference papers.- Generated a model for cytokine changes by evaluating cytokine changes' profile upon phosgene oxime exposure to test the effectiveness of the treatment strategy. Immunotoxicology, Acute toxicity, Dose-response study, and risk assessment.- Innovated the role of host MARCH proteins in processing Ebola virus glycoprotein as a therapeutic target. - Presented the role of host innate immunity SERINC proteins against HIV infectivity.

San Francisco, California, Us

- Quantified the role of shock and kill strategy for termination of HIV latency by eliminating its pool in T cells accompanied with antiretroviral therapy using a herbal extract.- 30000 USD grant and a conference paper.- Quantified different Iranian herbs and some of their derivates, looking for the most promising herbal extract and derivative to activate the latent HIV activation with minimum toxicity.

Karaj, Alborz, Ir

- Innovated an influenza HA2 DNA vaccine with Mx bio adjuvant using bioinformatic methods and quantified immune response in BALB/c mice using a prime-boost vaccination strategy.- 3 vaccine discovery, 5 peer-reviewed journal papers, 8 conference presentations, and papers.- Enhanced potency of FMD vaccine by inventing, and quantifying the potency, of a new oil-based adjuvant ISA 61 VG FMD vaccine. The new vaccine showed a PD50 value of 10.05 compared to a PD50 value of 4.17 for the old vaccine. This vaccine is now used for vaccination against FMD in Iran.

Paris, Fr

- Advanced T7 polymerase-driven expression system by assessing the possibility of replacing BVDV IRES instead of EMCV IRES, which is now commonly used for cytoplasmic expression of genes of interest or virus cDNA rescue experiments.- 3 method development, 3 peer-reviewed journal papers, 5 conference presentations.- Presented molecular characterization of strategically important bovine leukemia viruses circulating in various regions and climates in Iran, showing the presence of BLV genotypes 1 and 4.

Tehran, Tehran, Ir

- Directed a team of five graduate and 15+ DVM students, investigating viral molecular epidemiology to detect circulating viral strains to improve the vaccines in use.- 68 peer-reviewed journal papers, 28 conference presentations, and papers, 70000 USD grants in total, graduating 5 Ph.D. and 16 DVM students as the first supervisor.- Enhanced the methods of treatment and control strategies by quantifying the prevalence of viral strains and their pathogenicity in animal viral complex infections in a team-up with veterinarians. - Innovated a gamma-irradiated avian influenza vaccine candidate and confirmed the high-quality inactive vaccine production method, and quantified the efficacy of the new vaccine.

Master Of Science - Ms, Toxicology

Ph.D, Microbiology And Immunology