Madeline Tjai Email & Phone Number

Singapore

• Provide appropriate training and onboarding process for new associate analysts.• Lead chemist and reporting officer to three associate analysts.• Supervise, cross-check and validate associate analysts work and analysis results to ensure quality assurance. Help with troubleshooting of equipment and method if required. • Undertake the analysis on pre-race and post race equine specimens for the presence of prohibited substances.• Coordinate and ensure that weekly analysis of… Show more • Provide appropriate training and onboarding process for new associate analysts.• Lead chemist and reporting officer to three associate analysts.• Supervise, cross-check and validate associate analysts work and analysis results to ensure quality assurance. Help with troubleshooting of equipment and method if required. • Undertake the analysis on pre-race and post race equine specimens for the presence of prohibited substances.• Coordinate and ensure that weekly analysis of equine specimens are appropriately completed and accurately reported• Ensure that the laboratory meet the requirements set by ISO 17025 and SAC-SINGLAS.• Achieve a 100% record for analysis for AORC proficiency testing• Well-versed in using LIMS to enter results, generate reports and validation of results. Supervise, cross-check and validate associate analysts work and analysis results to ensure quality assurance. Help with troubleshooting of equipment and method if required. • Undertake development work to ensure that the methodology and scope of testing for compounds falling into the assigned area of analysis meets current needs of the organization.• Participate in internal and external audits.• Familiar with the operation, drug tuning, basic troubleshooting and front end maintenance various mass spectrometer systems: Thermo TSQ Altis, Thermo Q-Exactive, Thermo Q-Exactive plus, Thermo VelosPro, Sciex ,Qtrap 6500+ and Bruker TimsToF, Thermo TSQ9610, Thermo QE GC, Shimadzu HS-20, Shimadzu TQ8040• Extensive experience with instrument software packages such as Sciex Analyst and MultiQuant, ThermoFisher TraceFinder and Excalibur, Shimadzu LabSolutions and Bruker Compass Hystar.• Well versed in using semi-automated systems such as Tecan and Biotage for sample clean up and solid phase extraction.• Well versed in conducting validation process after method development and am responsible for writing the validation reports and SOP for the newly developed method to be run as a routine assay. Show less

The Academia, Sgh Campus

• Develop and validate bioanalytical methodologies such as LC-MS/MS (SCIEX 5500 QTRAP) and HPLC (Shimadzu Prominence) for drugs and drug metabolites monitoring according to FDA guidelines in support of clinical and preclinical studies• Proficient in solid and liquid phase sample extraction techniques for biological samples such plasma, serum, packed red blood cells, saliva, synovial fluid, cell and tissue lysates• Report writing for method validation and sample analysis• Provide… Show more • Develop and validate bioanalytical methodologies such as LC-MS/MS (SCIEX 5500 QTRAP) and HPLC (Shimadzu Prominence) for drugs and drug metabolites monitoring according to FDA guidelines in support of clinical and preclinical studies• Proficient in solid and liquid phase sample extraction techniques for biological samples such plasma, serum, packed red blood cells, saliva, synovial fluid, cell and tissue lysates• Report writing for method validation and sample analysis• Provide routine clinical analyses and timely result reporting to clinics• Execute all analyses in accordance to GLP and ISO 15189:2012 requirements• Involve in quality assurance check for analysis results• Participated as auditor for in-house internal and safety audit• Quality assessed other individuals report writing, laboratory work in order to check they met strict requirements.• Involve in SOP writing for quality management, technical protocols and equipment in compliance to ISO 15189 standards• Participate in proficiency testing and inter-laboratory comparison as part of competency assessment• Perform regular maintenance on analytical and accessory instrument• Provide appropriate training and onboarding process for new analytical chemists.• Cross-trained in molecular analyses such as pyrosequencing for SNP analyses, real-time quantitative PCR, high resolution melt-curve (HRM) analysis for projects and clinical testing• Perform routine ELISA analysis of biologic drug levels and its anti-drug responseSignificant Highlights• Developed and validated assays for the monitoring of colchicine, clozapine, ibuprofen, and endoxifen levels in clinical studies• Revalidated the thiopurine metabolites routine assay to remove undesirable analytes, reduce cycle time and improve efficiency of the assay.• Designed SNP analyses for the study of age-related macular degeneration • Part of the working team to attain ISO14001 and 45001 for SingHealth Clinical Pharmacology Show less

Boon Lay

Independent Research Project Jan 15- Present • Sample preparation of raw materials for chemical analysis.• Operation of LC/MS and NMR spectrometry and using them for chemical profiling, analysis and structural identification of organic molecules.• Other techniques: ATR-FTIR spectrometry for determination of lipids, polysaccharides and proteins in chemical compound• Verification of laboratory notebooks, media logbook… Show more Independent Research Project Jan 15- Present • Sample preparation of raw materials for chemical analysis.• Operation of LC/MS and NMR spectrometry and using them for chemical profiling, analysis and structural identification of organic molecules.• Other techniques: ATR-FTIR spectrometry for determination of lipids, polysaccharides and proteins in chemical compound• Verification of laboratory notebooks, media logbook, expiration dates of standards, reagents and test solution• Looking after the standardization and maintenance of analytical instrumentations and software.• Preparing and keeping general laboratory maintenance and functioning standards within safety and regulatory environments• Preparing reagents for chemical tests and reporting atypical results.• Ensure continuous flow of all necessary supplies and troubleshoot equipment in laboratory• Basic troubleshooting of LC/MS instrument. Show less

National University Hospital, Singapore

Clinical chemistry lab• Gained hands-on experience in in-patient laboratory testing• Gained hands-on experience in performing quality control checks for automation system in clinical chemistry laboratory Clinical Microbiology lab• Gained hands-on experience in identification of microorganisms in clinical microbiology laboratory• Performed plating and culturing of patients samples on culture plates in clinical microbiology… Show more Clinical chemistry lab• Gained hands-on experience in in-patient laboratory testing• Gained hands-on experience in performing quality control checks for automation system in clinical chemistry laboratory Clinical Microbiology lab• Gained hands-on experience in identification of microorganisms in clinical microbiology laboratory• Performed plating and culturing of patients samples on culture plates in clinical microbiology laboratory Molecular Diagnostic lab• Took a week long practical course in the molecular Diagnostic Centre learning PCR, electrophoresis, immunoflouresence screening and interpretation of results. Clinical Haematology lab)• Performed routine hematological testing for blood disorders using microscopy and results interpretation • Performed routine antibody screening for identification of blood type and results interpretation for patients• Perform flow cytometry and data analysis of Red Blood Cell indices. Show less

National University Hospital, Singapore

Final Year Research Project • Research project was entitled “Detection and Identification of Mycobacteria using genus-specific amplification of the 16S-23SrRNA”• Analysis and detection of 8 different strains of Mycobacteria using PCR • Project was presented at the NHG Annual Scientific Congress 2006• Findings were published in Annals Acad Med Singapore 2006; 35(suppl):10 (MP020)

Master'S Degree, Chemistry

Bachelor'S Degree, Biology/Biological Sciences, General, Honors

Bachelor's degree in Biological sciences

Diploma, Biomedical Technology/Technician