Michael Dimattia Email and Phone Number
Michael Dimattia work email
- Valid
- Valid
Michael Dimattia personal email
Michael Dimattia phone numbers
I am a biomedical researcher interested in structural biology, protein and nucleic acid chemistry and drug design. For 15 years, I have explored the molecular mechanisms underpinning many elements of health and disease, in a diverse set of disciplines from virology and immunology, to cancer biology and the development of gene therapy. While in early college I thought I was destined for medical school, I joined a lab that took a hybrid methods approach to structural biology, combining X-ray crystallography and cryo-electron microscopy (cryo-EM). I loved it so much that I changed paths and went on to get my PhD in structural biology. In my postdoc at Sloan Kettering, I introduced my colleagues to much of the methodology and practice of cryo-EM: from sample preparation, data collection, and single-particle image analysis to refinement of high resolution structures. With technological advances in direct-electron detectors and computational power, high resolution reconstructions are more achievable than ever, opening the door to molecular (and hopefully therapeutic) insights that have long been elusive. I am grateful to be a part of this seismic shift in molecular structure determination, and look forward to continuing on this path for years to come.
Schrödinger
View- Website:
- schrodinger.com
- Employees:
- 455
-
Principal Scientist IiSchrödinger Feb 2023 - PresentNew York City Metropolitan Area
-
Principal Scientist ISchrödinger Feb 2022 - Feb 2023New York City Metropolitan Area
-
Senior Scientist ISchrödinger Jul 2020 - Feb 2022New York City Metropolitan Area
-
Postdoctoral Research Fellow - Cryo-Electron Microscopy (Cryo-Em)Memorial Sloan Kettering Cancer Center 2014 - Nov 2019New York, NySUMO is a protein that is attached to other proteins (post-translationally) to regulate their function, typically by altering enzymatic activity, subcellular localization, or interfaces involved in other protein interactions. This modification regulates differentiation, apoptosis, the cell cycle, and response to stress. My postdoctoral work here involves RanBP2, a nuclear pore complex protein that catalyzes SUMOylation. I have in vitro reconstituted a relevant 11-protein human complex for structural investigation by cryo-EM and image analysis. This investigation will clarify how RanBP2 catalyzes SUMO attachment to proteins, and how this process may be important for nucleocytoplasmic transport and chromosomal segregation during mitosis, both processes that often go awry in cancer. -
Postdoctoral Research Fellow - Cryo-Electron Microscopy (Cryo-Em)National Institutes Of Health 2013 - 2014Bethesda, MarylandHIV Rev is a small regulatory protein that mediates nuclear export of viral RNAs -- an essential step in the HIV replication cycle. In this process, Rev cooperatively oligomerizes onto a highly structured RNA motif. My postdoctoral work here encompassed cryo-EM and helical image reconstruction of in vitro assembled Rev filaments, in order to better understand higher-order Rev oligomerization, and therefore Rev function. I also performed hot spot analysis of the protein-protein interfaces involved in order to better guide anti-Rev target development. -
Doctoral Graduate Student In Structural BiologyUniversity Of Oxford / National Institutes Of Health 2008 - 2013Oxford, United Kingdom / Bethesda, Md, UsaAnti-HIV drugs have been developed against several viral protein targets, including protease, integrase, reverse transcriptase, and more recently, envelope glycoproteins. However, no therapeutics exist that target HIV Rev, an essential viral protein that regulates the nuclear export of HIV RNAs needed for proper assembly of infectious particles during replication. I determined the crystal structure of HIV Rev in order to better understand how Rev coopts host cell mechanisms to assist HIV replication. Additionally, I pursued in silico fragment screening against our newly-determined crystal structures in order to initiate efforts toward the development of anti-Rev HIV inhibitors.
-
Lab ManagerUniversity Of Florida 2007 - 2008Gainesville, FloridaI brought a dedicated, detail-oriented, and energetic approach to managing a research lab of 12-15 members. I provided lab support to the research staff; maintained lab supplies, orders, and finances; and oversaw lab safety. In addition, I shifted from training lab members, as needed, to sustaining baculovirus tissue culture (viral capsid production) for lab and sample analysis via negative stain electron microscopy (EM). -
Undergraduate Research Fellow - Virus Crystallography / Cryo-Electron MicroscopyUniversity Of Florida 2004 - 2007Gainesville, FloridaI sought out basic science research in the lab of Dr. Mavis Agbandje-McKenna, studying parvovirus host cell recognition and entry. Specifically, I explored the connection between structure and function of various non-pathogenic viruses known as AAVs (adeno-associated viruses). Such viruses show promise for development as gene therapy vectors for treatment of hereditary diseases. Here, I first learned and employed X-ray crystallography and cryo-electron (cryo-EM) microscopy as techniques for structural investigation.
Michael Dimattia Skills
Michael Dimattia Education Details
-
Structural Biology -
Biochemistry And Molecular Biology
Frequently Asked Questions about Michael Dimattia
What company does Michael Dimattia work for?
Michael Dimattia works for Schrödinger
What is Michael Dimattia's role at the current company?
Michael Dimattia's current role is Principal Scientist in Structural Biology | Drug Discovery Group, Schrödinger.
What is Michael Dimattia's email address?
Michael Dimattia's email address is mi****@****ger.com
What is Michael Dimattia's direct phone number?
Michael Dimattia's direct phone number is (352) 392*****
What schools did Michael Dimattia attend?
Michael Dimattia attended University Of Oxford, University Of Florida.
What skills is Michael Dimattia known for?
Michael Dimattia has skills like Protein Expression, Molecular Biology, Protein Purification, Biochemistry, Structural Biology, Cell Culture, Protein Chemistry, X Ray Crystallography, Spanish, Editing, Genetics, Molecular Cloning.
Who are Michael Dimattia's colleagues?
Michael Dimattia's colleagues are Elvira Tarasova, David Nicholson, Shashi Rao, Shaghayegh Vafaei, Tukesh Ram Sahu, Darlene Heller, Volodymyr Babin.
Not the Michael Dimattia you were looking for?
-
2chillertechnology.com, chillertechnology.com -
Michael DiMattia
Boston, Ma2wellsfargo.com, ubs.com -
1gmail.com -
3comcast.net, gmail.com, delren.com
Free Chrome Extension
Find emails, phones & company data instantly
Download 750 million emails and 100 million phone numbers
Access emails and phone numbers of over 750 million business users. Instantly download verified profiles using 20+ filters, including location, job title, company, function, and industry.
Start your free trial