Mahmoud Saleh Email & Phone Number

Boston, Massachusetts, United States

Cambridge, Massachusetts, United States

• Key contributor to several cross-functional teams integrating clinical and pre-clinical data to advance drug candidates through hit-to-lead discovery, lead candidate optimization and IND submission activities• Lead Scientist on multiple projects focused on designing, developing and implementing in vitro and ex vivo T cell, macrophage and epithelial cell-based assays to support pre-clinical programs in inflammatory bowel disease, colorectal cancer and immuno-oncology• Integrated clinical and preclinical data to identify PD biomarkers of efficacy for VOWST, designed and implemented experiments to elucidate mechanism of action• Leveraged immunology expertise to use SER-287 clinical biopsy RNA-Seq data to stratify patient populations and design in vitro assays for target identification and validation• Lead Scientist in the clinical biomarker discovery effort for SER-155 Ph1b clinical trial, identified immunological targets for GVHD progression in HSCT patients• Managed several CROs and external collaborations to execute drug discovery strategy in an efficient manner• Contributed data and scientific writing to several patents covering clinical-stage products in ulcerative colitis, graft-versus-host disease and immuno-oncology• Directly supervised two junior scientists in developing and executing cell-based assays, analyzing and presenting data across functional teams• Technical expertise in mammalian cell culture, isolation and ex vivo culture of primary human innate and adaptive immune cells, multi-color flow cytometry, ELISpot and T cell cytotoxicity assays, Luminex, AlphaLISA, qRT-PCR, Nanostring gene expression, cell viability and proliferation assays, immunostaining and cell imaging

Cambridge, Massachusetts

Charlottesville, Virginia

• Initiated and managed research projects to investigate the roles of type 2 and type 3 immune responses in modulating the susceptibility to and severity of Clostridium difficile infection• Successfully discovered a novel role for colitis-induced Th17 cells in exacerbating the severity of C. difficile infection, and a therapeutic role for several type 2 cytokines in protecting against severe disease using mouse and human studies • Intellectually and scientifically collaborated with academic and industry scientists to understand and target the innate and adaptive immune system to protect against severe C. difficile infection• Technical expertise in in vivo mouse models, isolation and ex vivo propagation of primary immune cells from human blood and mouse tissue, multi-color flow cytometry (panel design, data acquisition and analysis), intracellular cytokine staining, in vitro cell culture, ELISA, qRT-PCR and Luminex• Directly mentored two undergraduate students and two junior graduate students in learning laboratory techniques, analyzing data, interpreting results and critically troubleshooting problems

Greensboro/Winston-Salem, North Carolina Area

• Performed active ingredient analyses on raw materials and finished agricultural products using High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) under GLP standards• Developed, validated and conducted chemical and biological assays on new formulations and final products• Generated and documented data reports to support global regulatory submissions

Greensboro/Winston-Salem, North Carolina Area

Designed and executed toxicology and RNA interference assays to determine the effects of Bisphenol-A (BPA) on the reproduction, morphology and survival of Caenorhabditis elegans

Greensboro/Winston-Salem, North Carolina Area

• Assisted professors with preparing and teaching lab classes and grading assignments, lab reports and exams• Tutored first and second-year students in basic and organic chemistry

Greensboro/Winston-Salem, North Carolina Area

Studied the association between motor neuron length and the onset of Amyotrophic Lateral Sclerosis (ALS) in a mouse model of disease using immunohistochemistry and fluorescence microscopy

Doctor Of Philosophy - Phd, Microbiology, Immunology And Cancer Biology, 3.856

Bachelor Of Science (B.S.), Biology, Chemistry, 3.97