Mariana Nave Email & Phone Number

antiSMASH, a python-based tool to mine micro-organisms genomes, currently uses pyQuery to generate static HTML pages. Consequently, several difficulties are found when improvements/changes need to be performed. This library is commonly described as too verbose, implying most of the times, string concatenations and mixed code for both presentation and logic. Subsequently, it is not much intuitive. In addition, recent patch update from 1.2.9 to 1.2.10 resulted in a backward compatibility break, and as a minor patch should not raise compatibility issues, the trust in this library is somehow compromised. Template Engines overcome the majority of the issues related to output generation. They are powerful tools that allow the developers to speed up their work in an easier and much cleaner way.This project proposes moving antiSMASH to jinja2, a well known, widely used and developer-friendly templating language for Python. With this migration, we intend to facilitate the future development of antiSMASH as well as the onboarding of new developers to the team. Moreover, considering jinja2 enormous user-base and applications, a backwards compatibility break in a minor version is unlikely.

SIMSEA - Agent-based Modelling and Simulation for Conservation and Resource Management in Azorean Seamounts

Ribosomally synthesised and post-translationally modified peptides (RiPPs) are a class of secondary metabolites that share a common biosynthetic origin - a precursor gene, encoded on the genome of a microorganism. It is translated to a peptide by the ribosome, and then further modified to give the active final product. RiPPs can be divided in more than 20 sub-classes and have a wide range of biological functions: among others, they can work as antibiotics, nutritional additives or food preservatives. Thus, the use of RiPPs as drugs is increasing and several RiPP derivatives are already in advanced phases of clinical trials. Prediction modules for a number of RiPP clusters were developed. http://antismash.secondarymetabolites.org/

Nanostructured Systems for Overcoming Biological Barriers- Animal Biosafety Level (ABSL) 3 experience.- In vivo evaluation of innovative therapies for Tuberculosis in mice.- Design of lipid-based nanoformulations as molecular probes aiming the development of a new diagnostic method for pulmonary infections

Nanostructured Systems for Overcoming Biological Barriers- Design and performance of a research project aiming the therapy of human melanoma and colorectal cancer.- Performed scientific research on drug delivery systems aiming a new biological target for cancer therapy.

Research work in Biological Transport: "Preparation of membrane vesicles from pig adipose tissue for permeability assays"

Research work in Biochemistry at the Final Project "Computer Aided Drug Design for COX2 inhibitors"

Master'S Degree, Biopharmaceutical Sciences, 18/20

Bachelor'S Degree, Biochemistry, 14/20

Master’S Degree, Bioinformatics