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Highly experienced Protein Scientist in biopharmaceutical research, specializing in protein purification, engineering, modification, and characterization to advance drug discovery and development. Recognized as an engaged and proactive collaborator consistently contributing to cross-functional research and early development project teams across diverse therapeutic areas including oncology, immunology, infectious diseases, and neuroscience. Demonstrated expertise in driving projects towards target objectives within tight timelines while managing concurrent high-impact early and late-stage collaborative research initiatives.
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Scientist 3 (Principal Scientific Researcher)Genentech Sep 2016 - PresentSouth San Francisco, California, UsDepartment of Structural Biology in gRED (Genentech Research and Early Development) • Protein purification lead and point-of-contact for early stage large molecule research portfolio projects.• Supported early stage small molecule research projects.• Consulted with project team leaders on construct selection for antibody campaigns.• Strategized with Project Team Leaders/Biology Leads to manage and prioritize protein reagent needs and requirements.• Hands-on development of purification strategies for challenging proteins.• Actively contributed to project teams and collaborated across multi-disciplinary teams to help advance programs to development. -
Program ManagerGenentech Jul 2023 - Dec 2023South San Francisco, California, Us6 month rotation as a program manager in the Portfolio Strategy Management department in gRED.• Supported a Pharmacology sub-team in an oncology pre-IND program.• Collaborated closely with the pharmacology sub-team leader and team members on key pre-IND activities.• Facilitated weekly sub-team meetings, overseeing the organization of agenda and meeting materials. •Tracked pre-IND study activities to ensure adherence to established timelines and to foster progress.
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Senior Scientific ResearcherGenentech Feb 2015 - Sep 2016South San Francisco, California, UsDepartment of Protein Chemistry and Structural Biology in gRED (Genentech Research and Early Development) - Biomolecular Engineering Group• Protein lead and point-of-contact for new early stage large molecule research projects.• Developed platform biochemical and biophysical techniques for protein formulation screening and thermal stability assessment.• Key member of multiple early stage immunology and cancer immunotherapy research project teams. • Enabled the transition of several early stage research projects to late stage research and/or development.
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Scientific Researcher (Research Associate)Genentech Mar 2006 - Feb 2015South San Francisco, California, UsDepartment of Protein Chemistry in gRED (Genentech Research and Early Development)• Purification team lead on ESR projects, focusing on the areas of cancer immunology and neurodegeneration. Independently designed, planned, and executed experiments to support early stage research projects.• Supported the development of novel therapeutic candidates by purifying research-scale amounts of lead and backup antibodies, affinity-matured antibodies, half-antibodies, and various antibody fragments.• Devised robust purification and refolding schemes for producing active protein. Co-refolded tagged and untagged multi-unit protein complexes. Generated critical protein reagents to advance project goals. • Further developed protein characterization skills in mass spectrometry, in-vitro endotoxin quantification, analytical SEC, laser light scattering (SEC multi-angle light scattering, dynamic light scattering), and thermal stability determination.
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Research AssistantGenentech Oct 2003 - Mar 2006South San Francisco, California, UsDepartment of Protein Chemistry in Research.• Purified recombinant proteins expressed from 0.5 to 35L scale in prokaryotic, insect cell, and mammalian systems. Successfully refolded proteins expressed as insoluble E. coli inclusion bodies for use in antibody generation, assay development, functional activity assays, target screening, and structural biology.• Applied chromatography techniques such as affinity (IMAC, GST, FLAG, Protein A, Protein G, Protein L), ion exchange, hydrophobic interaction, and size exclusion chromatography using GE AKTA Express, Purifier, and Explorer systems. • Characterized proteins using techniques such as SDS-PAGE, protein concentration determination (A280, Bradford assay, BCA assay), western blot, mass spectrometry, endotoxin quantification, and peptide mapping.
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Assistant Research Scientist IExelixis, Inc. Jul 2002 - Aug 2003Alameda, California, Us• Purified proteins from E. coli and baculovirus expression system (BEVS) for use in assay development, high-throughput screens, and structural studies. Produced proteins from milligram to gram scale expressed in 0.5 – 100L fermentation volumes.• Assisted in the purification of 300 protein kinases within a two-month period for the generation of a selectivity panel, resulting in the identification of novel targets. -
Undergraduate Student ResearcherUniversity Of California, Davis Jan 2001 - Jun 2002Davis, California, Us• Optimization of the recombinant E. coli expression and purification of the plant photoreceptor phytochrome. Purified GST and His-tagged proteins using gravity flow affinity columns. Characterized proteins using SDS-PAGE and spectrophotometric readings.• Purified native phycocyanobilin pigments from Spirulina using an organic solvent extraction method and C18 reversed-phase chromatography. Analyzed pigment samples on C18 reversed-phase HPLC.
Manda Wong Education Details
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Northeastern UniversityBiotechnology -
University Of California, DavisBiochemistry And Molecular Biology
Frequently Asked Questions about Manda Wong
What company does Manda Wong work for?
Manda Wong works for Genentech
What is Manda Wong's role at the current company?
Manda Wong's current role is Protein Biochemist | Project Manager.
What is Manda Wong's email address?
Manda Wong's email address is ma****@****mni.com
What is Manda Wong's direct phone number?
Manda Wong's direct phone number is +1.650.225*****
What schools did Manda Wong attend?
Manda Wong attended Northeastern University, University Of California, Davis.
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