Mansi Arora, Ph.D Email & Phone Number

Cambridge, Massachusetts, US

Cambridge, Massachusetts, US

Lexington, MA, US

Boulder, Colorado, US

• Focus areas: Cancer Cell Biology, DNA damage response, Cell Proliferation, High-content imaging, Single-cell Biology, Cellular heterogeneity, Live-cell imaging.
• Generated hypotheses and designed experiments to investigate target dependency using chemical biology and single-cell biology approach as part of industry collaboration.
• Utilized high-throughput imaging assays followed by quantitative image analysis to measure variability in gene and protein expression.
• Generated mammalian cancer and non-cancer stable cell lines using lentiviral transductions for long-term live-cell imaging of biosensors and fluorescently-tagged proteins involved in cellular proliferation and DNA.
• Applied a live-cell quantitative DNA damage analysis to identify endogenous DNA damage as an underlying cause of phenotypic heterogeneity within isogenic cell populations.
• Managed external collaboration by preparing project reports, regular presentation of findings and timely delivery of project goals.

Columbus, Ohio, US

• Focus areas: EPIGENETICS, MOLECULAR biology of CANCER
• Used cell-based DNA repair reporter assays, immunofluorescence, immunoblots, and immunohistochemistry of tumor microarrays to investigate novel players in the homologous recombination pathway.
• Contributed to a collaborative study examining the role of CDK1 in BRCA1-mediated DNA damage response by performing cell-based DNA repair assays.
• Utilized next-gen sequencing (ChIP & ChAP-Seq) to discover a mechanism of transcriptional memory conservation via ubiquitination of chromatin proteins.
• Using extensive literature search, created a list of potential ubiquitin ligases and deubiquitinases involved in the bookmarking process.
• Performed molecular assays to establish novel roles for proto-oncogenic proteins of the PRC1 and SAGA complex in the regulation of active gene expression.

Columbus, Ohio, US

• Taught and managed two sections of undergraduate introductory biology course.
• Set up the experiments and assisted students in performance with the experiments
• Assisted in preparation of upcoming laboratory periods
• Led review sessions of coursework and helped faculty with classroom instruction

Athens, Ohio, US

• Taught and managed 2 sections of undergraduate advanced microbiology course.
• Provided laboratory instruction, assisted faculty with classroom instruction
• Setup the laboratory, assist students with experiment performance, enforced safety while working in the laboratory.
• Setup and and grade exams and assisted students with coursework during office hours

Vadodara, Gujarat, IN

• Thesis title "Role of PARP during development in Dictyostelium discoideum"
• Designed experiments and analyzed data to determine the role of oxidative stress and the enzyme PARP in development and cell death in Dictyostelium discoideum.
• Gained experience in culturing of D. discoideum and essential cell culture techniques.

Ahmedabad, Gujarat, IN

Gained knowledge of basic molecular biology and biochemistry techniques related to gene cloning

Doctor Of Philosophy (Ph.D.), Molecular Cellular And Developmental Biology

Master Of Science (Ms), Biochemistry And Molecular Biology

Bachelor Of Science (B.Sc.), Biochemistry