Mansoor Saeed Email and Phone Number

•Investigating and identifying new research themes for analytical metabolism.•Leading a small team undertaking metabolite ID and structural characterization in support of product registrations and on-going research within Syngenta’s product portfolio.•Assessing resource, planning and executing complex analytical projects to GLP standards, producing audited reports for regulatory purposes through management skills and experience in planning, problem solving and science.•Aiding exploratory, stewardship and development decisions.•Performing high resolution accurate mass spectrometry (MS) work and research into new LC-MS/MS techniques to meet global business requirements•Solving key technical problems using a wide range of MS, separation science techniques•Developing novel applications of MS to ensure international business requirements are met.•Interpretation of data and make recommendations for further work taking into account regulatory implications.•Internal / external presentations to enable regulatory submission of reports.•Design and perform mass spectrometric investigations into the metabolic (profiling, metabolite ID) analysis of biological species, photolysis, hydrolysis, environmental, dietary fate of crop protection products . •Structural characterization of small molecules and biopharmaceuticals. •Study Director / Principal Investigator– responsible for setting up GLP Characterization service for metabolite reference standards and deputy archivist.•Supporting new AI products in development by leveraging external resources (instrument manufacturers, universities, contract research organizations (CRO’s) and small medium enterprise (SME)).•Evaluation and introduction of new chemoinformatic tools, mass spectrometry and separation science technologies.•Tender and procurement of mass spectrometry and analytical equipment.•Implementation of ultra-high resolution and high accurate mass spectrometry for the Syngenta worldwide business.

•Responsible for preparing business proposals on investigation of new areas of science allied to LGC business.•Established analytical protocols in the agrochemical, biochemical, health and pharmaceutical industries (e.g. for specialist applications and establishing purity profiles, characterisation of synthetic products and small molecules using CE-MS, CEC-MS and LC-MS/MS). •Responsible for the technical leadership of a team of separation scientists •Developing and transferring new separation technologies and LC-MS/MS generic methods into an analytical service.

• To identify and implement new analytical methodologies in separation science, mass spectrometry, sample extraction technologies and product characterisations for small molecules.• Analytical development of CE; on aspects such as increasing sensitivity (using novel fluorescence and data collection techniques) and interfacing with mass spectrometry collaboration with Imperial College. • Responsible for tender and procurement of mass spectrometry equipment.• Responsible for establishing CE-MS and CE as an analytical service.• Presentation of analytical data at international and national conferences.• Development of capillary isoelectric focussing for protein characterisation and protein affinity studies using capillary electrophoresis. • Extensive experience in project, people management and development.• A PhD examiner for the University of Leeds, Chemistry Department.

Bio-analytical chromatography (low dispersion, capillary electrophoresis and electrochromatograhy). Responsible for day-to-day management of a research laboratory and supervision of B.Sc (Hon’s) / M.Sc final year projects. Identification of new research themes in analytical method development and validation using HPLC and CE. • Developed chiral CE methods for main peak AI and counter ion.• Conducted research into multi-dimensional chromatography for bio-analysis.• Responsible for the investigation of chiral recognition mechanism for cellulose columns collaboration with University of McGill.

Responsible for management of analytical staff and analytical studies and experimental work. • Collaborated with external parties to expand science base and investigate new areas of business.• Conducted spectroscopic (Mass Spectrometry and FTIR) and chromatographic characterisations.• Method development and implementation of bio-analytical studies.• All laboratory work and documentation were performed to GLP, FDA and ICH guidelines.