Developed OptFlux Benchtop Software for Flux Analysis & Cytoscape plug-ins (collaboration) to support visualization and simulation of fluxes.Applied flux methodology to multiple biofuel related programmes: NORTH (biobutanol), OMEGA-3 (PUFA), ICBR (cellulosic ethanol) and BIO3G (PDO). Made many recommendation as to KU/KO/KDe.g. compartimentalization/transport and regulators.A program to compare and compute gene environment based operons by comparing all genomes simultaneously (pattern detection).Perfomed/validated multiple metabolic reconstructions.Developed 4 revolutionary new methods in protein engineering (for enzyme business.)Performed and implemented several highly accurate gene annotation methodologies and applied on over 100+ genomes.Developed and designed GC-MS metabolite identification program and methodology.Build comprehensive structural compound database.Build and designed computational atom-atom mapping algorithms.Made several discoveries, using transcriptomics, genomics, metabolomics.

Developed and implemented for the first time,algorithm "Mimas" (minimum model for alternative splicing).Methodology replaced full-time manual annotation by some 30 people.

Developed algorithms for EST alignment covering about 10 calasses of artifact (like repeats etc).Developed equivalent of SIM4 (spliced alignment) earlier in time.Developed double hierrachical clustering of transcriptomics ('QEA') before advent of microarray by Affy.Developed HMC for gene discovery.Developed methodology for real time mining complex database table sof unprecendented size.

Published numerous papers (60+). Invited talks. Graduate students.Supercomputer CM-5.Cutting edge algorithms, numerical methods, mathLead author of a general low-frequnecy theory of laser-atom interactions.

Lead author of a implications of general high-frequency theory of laser-atom interactions.Discovery of 'dichotomy' and 'high-intensity stabilization'Founder of field of 'stabilization of atoms in laser fields'.Most citated author in that field. (1000+ citations).