Marc Rideout, Ph.D.

Marc Rideout, Ph.D. Email and Phone Number

Protein Biochemist @ Tyra Biosciences
carlsbad, california, united states
Marc Rideout, Ph.D.'s Location
San Diego, California, United States, United States
Marc Rideout, Ph.D.'s Contact Details

Marc Rideout, Ph.D. work email

Marc Rideout, Ph.D. personal email

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About Marc Rideout, Ph.D.

My expertise, at the interface of chemistry and biology, was forged from 24 years as a researcher. I specialized in the production of high-quality macromolecules for structural biology experiments; specifically, purified proteins, peptides, DNA and small molecules. I also have expertise in the production of molecular probes, diagnostic tools that are useful for enzymology and high-throughput drug discovery. My research has been published numerous peer-reviewed journals based on the work I did in industry, graduate school and during a postdoctoral fellowship in France; truly an amazing experience.I am also passionate about science education. I believe that the next generation of scientists need excellent training, inspiration, and guidance and I have been fortunate to have had the opportunity to spend time teaching that generation in the classroom. I have also mentored a handful of students that have gone on to careers in biotechnology industries, endeavors that brought me a great sense of pride. Finally, I pleased to announce that I have started a new job at Tyra Biosciences. Tyra is a precision oncology company that is developing therapies to overcome tumor resistance and improve outcomes for patients with cancer. My past experiences in chemistry, crystallography, and protein biochemistry mesh well with the core competencies at Tyra, positioning me to make meaningful contributions toward achieving the company goals. It is also an excellent opportunity for personal growth and within the context of a supportive and amazing group of scientists.

Marc Rideout, Ph.D.'s Current Company Details
Tyra Biosciences

Tyra Biosciences

View
Protein Biochemist
carlsbad, california, united states
Website:
tyra.bio
Employees:
10
Marc Rideout, Ph.D. Work Experience Details
  • Tyra Biosciences
    Principal Scientist
    Tyra Biosciences Jan 2023 - Present
    Carlsbad, California, United States
  • Monserate Biotech Llc
    Scientist
    Monserate Biotech Llc Apr 2019 - Feb 2023
    Greater San Diego Area
    At Monserate Biotechnology Group, we strive to provide affordable, high quality products and and contract research services to the biotech community. As a scientist, I focus on building new relationships, maintaining all existing relationships, and expanding our existing product line.
  • Grossmont College
    Adjunct Faculty
    Grossmont College Jul 2017 - Dec 2017
    Greater San Diego Area
    As adjunct faculty and part-time biology instructor, I endeavoured to educate students in general aspects of life science and encourage them to pursue careers in science and medicine. Grossmont College serves a broad and ethnically diverse population in San Diego County and is an important stepping stone for students from all walks of life who are looking to transfer to four-year institutions and then matriculate to careers in science and medicine. I was proud to be a part of an institution that promotes those goals.
  • Communauté Université Grenoble Alpes
    Postdoctoral Fellow
    Communauté Université Grenoble Alpes May 2013 - Apr 2015
    Grenoble, France
    DNA damaging chemotherapeutics that are used in the treatment of cancers can become ineffective as DNA repair pathways are upregulated; therefore, compounds that exacerbate DNA damage are sought after as co-treatments with front-line chemotherapeutics. As a postdoctoral fellow I designed a molecular beacon that reports on non-enzymatic cleavage of DNA at abasic sites. The beacon is useful in high-throughput screening formats and I used it to identify several compounds from a chemical library that cause DNA cleavage at abasic sites. In addition, compounds that inhibit DNA repair enzymes are also sought after as co-treatments with front-line chemotherapeutics. To pursue this problem on both fronts, I established an international collaboration with Torrey Pines Institute for Molecular Studies to screen their mixture-based chemical libraries for compounds that inhibit the activity of a DNA repair enzyme, APE1.
  • San Diego State University
    Ph.D. Student
    San Diego State University Sep 2004 - Aug 2011
    San Diego
    Dissertation: Analysis of Holliday junction Binding CompoundsHolliday junctions (HJ) are formed during genetic recombination and are critical intermediates in DNA repair pathways. During my dissertation, I synthesized a family of analogous small molecules and demonstrated that they inhibit the resolution of HJs in DNA repair and DNA recombination assays. I demonstrated that the compounds had antibacterial activity and I used fluorescence-based quenching assays to model binding to the HJ (Mol. Divers. 2011 Rideout). In addition, I published work on a independent set of small molecules (Bioorg. Med. Chem. Lett. 2010 Ranjit) and a set of peptides (Peptides 2013 Rideout) that also inhibit HJ resolution. I also worked on a project to determine the structure of the inhibitors bound to a HJ. I pursued this goal by crystallography and NMR. As a result, I received training in the preparation of stable-isotope labeled peptides for NMR, basic 2D and 3D NMR experiments, and I strengthened my skills as a crystallographer.
  • San Diego State University
    Lecturer And Mentor
    San Diego State University Sep 2003 - May 2010
    San Diego
    For five semesters during my PhD I supervised, and provided lectures to, an upper division biochemistry laboratory. Classes were twice a week, three hours a day, and topics covered general biochemistry, enzyme kinetics, bioinformatics, protein purification, cloning and microbial genetics. In addition, I mentored four undergraduate researchers and one masters student who learned to perform assays in our laboratory using advanced techniques in molecular biology and biochemistry.
  • Decode Genetics
    Research Specialist I
    Decode Genetics Jan 2001 - Jan 2003
    Bainbridge Island, Wa
    I collaborated on contract research with major clients as well and performed internally funded primary research, most notably on human tyrosyl-DNA phosphodiesterase 1 (hTdp1). I synthesized and characterized nucleotide and oligonucleotide fluorescent substrates for hTdp1. I developed protein purification methods, produced protein crystals, aided in refinement and solution of crystal structures involving hTDP1 which led to multiple publications (Nucleic Acids Res. 2004 Rideout; J. Mol. Biol. 2004 Raymond). In addition I managed supplies for the biochemistry department and maintained machinery (HPLC, FPLC, oligonucleotide synthesizer).
  • San Diego State University
    Research Technician
    San Diego State University Jan 2000 - Jan 2001
    I designed, synthesized and purified several oligonucleotides with different terminal derivatives that were useful in characterizing the kinetics of modified oligonucleotides as substrates for hTDP1.I was also responsible for maintaining a chemical inventory, ordering supplies and maintenance of equipment as well as other managerial duties.
  • San Diego State University
    Undergraduate Intern
    San Diego State University Jan 1998 - Jan 2000
    I performed mentored research with Principal Investigator Dr. Douglas B Grotjahn involving the synthesis and purification of a novel Palladium (II)-Pyrazole complex. Specifically, I carried out the synthesis, reverse phased purification and re-crystallization of complex. I also aided in complex characterization by 1H NMR and presented data annually at group meetings.

Marc Rideout, Ph.D. Skills

Chromatography High Throughput Screening Mixture Based Chemical Libraries Cell Biology Western Blotting Gel Electrophoresis Organic Synthesis Biotechnology Pcr Life Sciences Dna Synthesis Fluorescence Molecular Biology Protein Crystallization Enzyme Kinetics Microbiology Protein Expression Genetics Biochemistry Dna Extraction Structural Biology Peptide Synthesis Hplc Ms

Marc Rideout, Ph.D. Education Details

Frequently Asked Questions about Marc Rideout, Ph.D.

What company does Marc Rideout, Ph.D. work for?

Marc Rideout, Ph.D. works for Tyra Biosciences

What is Marc Rideout, Ph.D.'s role at the current company?

Marc Rideout, Ph.D.'s current role is Protein Biochemist.

What is Marc Rideout, Ph.D.'s email address?

Marc Rideout, Ph.D.'s email address is mr****@****dsu.edu

What schools did Marc Rideout, Ph.D. attend?

Marc Rideout, Ph.D. attended Université Grenoble Alpes, San Diego State University And University Of California San Diego, Joint Doctoral Program, San Diego State University-California State University.

What are some of Marc Rideout, Ph.D.'s interests?

Marc Rideout, Ph.D. has interest in Real, These Are All Hobbies, 4 Handicap, Snowboarding, Many Other Outdoor Activities, Baseball, Hiking, Golf, Home Remodeling.

What skills is Marc Rideout, Ph.D. known for?

Marc Rideout, Ph.D. has skills like Chromatography, High Throughput Screening, Mixture Based Chemical Libraries, Cell Biology, Western Blotting, Gel Electrophoresis, Organic Synthesis, Biotechnology, Pcr, Life Sciences, Dna Synthesis, Fluorescence.

Who are Marc Rideout, Ph.D.'s colleagues?

Marc Rideout, Ph.D.'s colleagues are Cory Scott, Melissa Ye, Kirk Nelson, Tonya Blizzard, Phoebe Massey, Eric A..

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