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Major Achievements:Operations and business development• Development of a positioning and communication strategy for the production technology of Cilian AG within the frame of strategy workshops for business plans and the financial rounds.• Attracted in the management four financial rounds with private and international institutional investors (1st: 2 Mio. Euro, 2nd: 4,5 Mio. Euro, 3 rd: 1 Mio. Euro, 4th: 1,7 Mio. Euro), accompanied investment and shareholder agreements.• LOIs, research contracts, proof of principle-, evaluation-, and research and service contracts with 3 big pharma partners and 2 biotech companies, licence- and patent transfer agreements with 2 big pharma partners.Research and Development:• Hired and managed a highly qualified and successful team of 22 scientist and technicians, • Inventor of 8 patent applications and 3 granted patents, • R&D budget of about 7,5 Mio Euro, • Hired four national grants for Cilian (TIP, BioChancePlus, ZIM) and an international grant (EU) with a total project volume of 4.5 Mio. Euro,• Set up of two R&D laboratory locations, involved in the planning of a new 380 m2 research laboratory together with the Incubator Centre (Technology Park Münster GmbH),• First biosafety study for Ciliates, first animal study for enzymes derived from Ciliates, first animal study for a vaccine derived from Ciliates.Major R&D breakthrough: Worldwide first expression and secretion of a functional human biopharmaceutical enzyme (DNase I) in Ciliates,Worldwide first animal study for an enteric-coated Ciliate enzyme preparation for the treatment of exocrine pancreatic insufficiency,First licence option of a new expression plattform to an international pharma company.Specialties: Special management know how:• Accompanying the start up process from its early stage in an entrepreneurial manner within an interdisciplinary team.• Fund raising e.g. author of the business plans and presentations to venture capitalists as well as other potential investors.Special scientific know how:Enzyme preparation for oral substitution therapy, continuous fermentation, purification of proteins, process improvement.
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Lead ScientistC&L Research Gmbh May 2024 - Present
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Lead ScientistC&L Research Gmbh May 2024 - Present
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Chief Scientific OfficerCilian Ag Jan 2001 - PresentDeFounder and CSO (Vorstand F&E) of CILIAN AG, MünsterCilian is a privately held biotechnology company developing and marketing a novel expression system. The Company uses a species of Ciliates, a eukaryotic single-cell organism, for the production of enzymes and therapeutic proteins. As founder and CSO started and established the company.Primary responsibilities as CSO:Research and Development and Cooperation Projects• Formulation of R&D strategies to develop a high performance expression system for the production of biopharmaceuticals based on Ciliates (especially cloning, pilot scale fermentation and purification)• Recruitment, set up and supervision of the R&D team • Technical set up of the research laboratories of Cilian AG• Implementation of general R&D operations including a matrix structure, project management and first steps of quality management (MCBs and WCBs)• Networking with the international scientific community• Design, initiation and monitoring of five animal studies together with the CEO and Contract Research Organisations• Initiation and administration of patents and other intellectual property rights• International representation of the company as CSO on scientific conferences, congresses, partnering-, investor meetings and trade fairs -
Chief Scientific OfficerCilian Ag Jan 2001 - PresentDeI spent my scientific career investigating protozoan organisms, particularly Ciliates. I worked for the central research department of Aventis, Frankfurt (Germany), a later Sanofi subsidiary, earned my doctorate (summa cum laude) and was a postdoc in the academic working group of Prof. Tiedtke at the University of Münster. My postdoctoral study dealt with basic research in the field of protozoa and the commercial applications of protozoan organisms, which was funded by the European Commission. Based on my extensive scientific experience in the field Ciliate biotechnology, I founded Cilian in 2001, and since then I headed the company’s R&D team and operations.I am author of numerous scientific publications, recitations, patents and patent applications in the area of Ciliate biotechnology. One of the main breakthrough of my team was the first-ever expression of therapeutically usable protein in Ciliates, human DNAse I. Later, we could transfer the unique features of Ciliates for production of biopharmaceuticals, to therapeutic enzymes, protein based subunit vaccines and monoclonal antibodies against cancer, which we tested in POP studies and animal trials. Meanwhile I am heading an R&D team of 20 technical and scientific experts with an overall total budget responsability of € 35 million. -
Scientific AssistantUniversity Of Münster Jan 2000 - Jul 2001
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Postdoctoral FellowWestfälische Wilhelms-Universität Münster Jan 1999 - Jan 2001
Marcus Hartmann Skills
Marcus Hartmann Education Details
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University Of MünsterDiplom Biologe -
University Of MünsterPhd Student
Frequently Asked Questions about Marcus Hartmann
What company does Marcus Hartmann work for?
Marcus Hartmann works for Cilian Ag
What is Marcus Hartmann's role at the current company?
Marcus Hartmann's current role is The Ciliate advantage for biopharmaceuticals.
What is Marcus Hartmann's email address?
Marcus Hartmann's email address is ha****@****lian.de
What is Marcus Hartmann's direct phone number?
Marcus Hartmann's direct phone number is +4925162*****
What schools did Marcus Hartmann attend?
Marcus Hartmann attended University Of Münster, University Of Münster.
What are some of Marcus Hartmann's interests?
Marcus Hartmann has interest in Windsurfing.
What skills is Marcus Hartmann known for?
Marcus Hartmann has skills like Biotechnologie, Pharmaindustrie, Biowissenschaften, Molekularbiologie, Pharmaforschung, Biopharmazeutika, Forschung Und Entwicklung, Immunologie, Proteinchemie, Zellbiologie, Biotechnology, Vaccines.
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