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-Accomplished R&D translational scientist with extensive drug discovery expertise in pharmaceutical industry across multiple disease indications including inflammatory and autoimmune, respiratory, rare diseases, oncology, and neuroscience.-In depth expertise in development of integrated discovery and translational pre-clinical plans-Focus on applying insights from human disease biology (observational cohorts and clinical data) into development of novel therapeutic entities-Project leader of multidisciplinary project teams with track record of bringing NMEs from concept to developmentSpecialties: Innate Immunity and Inflammation, small and large molecule drug discovery, translational research, biomarker plans
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Senior Director, Translational Science Leader / Rare DiseasesIpsen Nov 2021 - PresentBoulogne Billancourt, Fr•Translational biology lead for oncology epigenetics pre-clinical portfolio (multiple assets from lead selection to FIH). Responsible for biology strategy, indication selection and translational plans•Translational research lead for late-stage clinical assets (Palovarotene, Elafibranor, Tazverik). Responsible for disease biology and pharmacology support including non-clinical pharmacology sections for regulatory submissions and biomarker and life cycle management strategies.•Member of IPSEN’s external innovation neuroscience core team. Responsible for due diligence and external opportunity evaluation of assets (early to late stage) through rigorous assessment of preclinical/translational data and delivery of clear recommendations including risk assessment and mitigation plans. -
Head Of Translational Pharmacology / RespiratoryNovartis Institutes For Biomedical Research (Nibr) May 2017 - Dec 2021Basel, Baselstadt, Ch•Built and led translational pharmacology research team (20 scientists) responsible for in vitro and in vivo translational disease models to support the advancement of drug discovery projects for respiratory indications.•Utilized OMICs patient data from observational cohorts and internal clinical studies to derive drug development insights.•Contributed oversight and strategy development for respiratory portfolio from early discovery stage into FIH.•Led antibody project for asthma from lead generation through candidate selection with the goal of fixed dose combination with another Novartis asset.•Research lead for CJ117, an inhaled anti-TSLP Fab on the Global Clinical Development Team. -
Translational Pharmacology / Inflammation And RemodelingPfizer Aug 2011 - Apr 2017New York, New York, UsPrincipal Scientist / Director / Senior Director•Led in vitro translational research group focused on biomarker development and immune mechanism of action studies in SLE, IBD, RA, respiratory and renal disorders.•Engaged research project leaders and clinical teams to formulate strategies to implement translational pharmacology and biomarker plans into early clinical programs (FIH and POC).•Developed pharmacodynamic and patient stratification biomarkers utilizing diverse technologies and OMICS approaches to support pre-clinical in vivo and early clinical studies (FIH to POC).•Established and/or participated in several external collaborations with academics and CROs for mechanism of action studies and access to patient samples •Project lead for small molecule inhibitor program for IBD -
Research Scientist / Inflammation And AutoimmunityWyeth Pharmaceutical Co., Ltd. Jan 2001 - Dec 2010Principal Research Scientist I/IIResearch Scientist I/II•Facilitated progression of small and large molecule discovery projects in inflammatory disorders through the pipeline with delivery of cell-based and biomarker assays •Target ID and validation for autoimmune and respiratory indications utilizing OMICs approaches.•Biology lead for multiple early pipeline projects, responsible for setting up screening cascades for diverse classes and drug targets in inflammation and innate immunity
Margaret Fleming Skills
Margaret Fleming Education Details
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Brandeis UniversityBiochemistry -
PhdDoctor Of Philosophy (Phd)
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University Of MiamiBiochemistry
Frequently Asked Questions about Margaret Fleming
What company does Margaret Fleming work for?
Margaret Fleming works for Ipsen
What is Margaret Fleming's role at the current company?
Margaret Fleming's current role is Senior Director, Translational Science Leader.
What is Margaret Fleming's email address?
Margaret Fleming's email address is ma****@****ibr.com
What is Margaret Fleming's direct phone number?
Margaret Fleming's direct phone number is +121257*****
What schools did Margaret Fleming attend?
Margaret Fleming attended Brandeis University, Phd, University Of Miami.
What skills is Margaret Fleming known for?
Margaret Fleming has skills like Inflammation, In Vitro, Assay Development, Respiratory Disease, Drug Discovery, Cell, Biomarker Discovery, Translational Medicine, Drug Development, Biomarkers, Pharmacology, Cell Signaling.
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