Maria Karasarides, Ph.D. Email and Phone Number
As a scientist and drug developer, my mission is to deliver value to patients and innovation to the marketplace. I develop strategy and drive transformational change by building high performance teams and uniting people to share a vision for shaping the future of healthcare. I am passionate about scientific discovery, improving the patient experience and delivering clinically meaningful solutions to real-world problems. I create value by translating science and technology into innovative products and practices to improve the lives of patients and ignite business growth. With a proven track record in leading biopharma organizations, my experience spans early- and late-stage drug development, pipeline strategy, registrational trial execution, drug launch, and AI powered precision medicine. Bridging strategy and deliberate execution to business outcomes, I consistently deliver accelerated pipeline growth and successfully lead teams to achieve growth, prioritize the patient needs with equity and inclusivity, and maintain focus in times of uncertainty. My roots in academic science were anchored in the Ras-Raf-MAPK pathway and led me, in 2004, to validate B-Raf as a therapeutic target in melanoma. In 2006, I joined the pharmaceutical sector and within a few years witnessed the impact of novel immune therapies on the lives of patients. Through the development and approval of Yervoy® we delivered the first cancer immunotherapy that would revolutionize cancer treatment paradigms and would enliven our hope for cancer cures. During the past decade, I contributed to the late-stage development and approval of the PD-L1 checkpoint inhibitor Imfinzi® and led numerous early-stage clinical programs designed to maximize the efficacy of checkpoint blockade through novel combinations or bring forward novel immunotherapy targets and therapeutic modalities, including CD3 and CD28 directed bispecific antibodies. As grateful as I am for the progress we made, I am deeply aware that most cancer patients treated in real-world practice do not experience their own personal cure. Making real progress in the coming decade will demand the integration of predictive technologies to improve drug development paradigms, a deliberate focus on precision medicine, and innovation strategies that meaningfully improve patient care. Mindful of this, together with my collaborators I founded GUIDE.MRD, a public private partnership that will advance our confidence in ctDNA diagnostic assays and aim to develop minimal residual disease (MRD) as a clinical decision tool for solid tumor malignancies.
Primary Venture Partners
View- Website:
- primary.vc
- Employees:
- 58
-
ExpertPrimary Venture Partners Nov 2024 - PresentPrimary is NYC's premier early-stage venture firm working alongside founders and visionaries to build unicorns companies that bring innovation to the marketplace. As an Expert, I provide strategic advice and guidance to the investment team and founders within the Primary portfolio and their broader network. -
Scientific Advisory BoardRevivemed Aug 2024 - Present"Revolutionizing Precision Medicine with the Power of AI and Metabolomics" -
Scientific Advisory BoardPicture Health Aug 2024 - Present"Accessable Precision Oncology Biomarkers" -
Vice President, Early Assets & Biomarkers, Ww Medical OncologyBristol Myers Squibb Apr 2020 - Nov 2023United StatesLed a multi-focal team to deliver the oncology early asset pipeline through proof-of-concept governance decisions and oversaw the diagnostic readiness strategy for oncology launches. Piloted the oncology “medical innovation” strategy and delivered pilot programs to address gaps that impede product use in clinical practice and accelerate clinical development. - Founded GUIDE.MRD, a new public private partnership under the Innovative Health Initiative (IHI), aiming to advance ctDNA based MRD assessment by liquid biopsy in patients diagnosed with solid tumor malignancies. Under my leadership GUIDE.MRD was awarded 35M € (GUIDE.MRD press release and Factsheet) and was established as one of 5 inaugural precision medicine projects (award announcement) co-funded by Horizon Europe. - Led the development of an AI-assisted augmented reality digital pathology platform to help pathologists achieve accurate PD-L1 scoring. This four-part evidence generation projects framed a roadmap for trustable AI algorithms and laid out the design features of an on-demand digital assistant that can be integrated into routine pathology practice. - Advanced the company’s radiomics strategy as part of an enterprise objective to accelerate the pipeline through the identification of novel endpoints and patient segmentation strategies. -
Executive Director, Oncology, Global DevelopmentRegeneron Pharmaceuticals, Inc. Jul 2017 - Apr 2020Greater New York City AreaLed the cross-functional development teams for the solid tumor early development oncology pipeline. Accountable for development program strategy, IND submissions, drug supply planning, program budget and program governance. - Led the early development programs of the oncology pipeline including REGN3767 (Lag-3 and iPET Lag-3), REGN4659 (CTLA-4), REGN6569 (GITR), REGN4018-19 (MUC16xCD3), REGN5668 (MUC16xCD28); REGN5458 and REGN5459 (BCMAxCD3), REGN5093 (METxMET), REGN5093-ADC (METxMET-M114).- Headed cross functional development teams, program strategy, IND submission, drug supply demand planning and program budget.- Drove governance with CEO & CSO and successfully achieved program-wide Go / No-Go decisions. -
Sr. Director, Clinical, Global Medicines DevelopmentAstrazeneca Jul 2014 - Jun 2017Drove the oncology novel-novel combinations development program in collaboration with peer pharma companies to identify accelerated approval opportunities for durvaluab and tremelimumab as part of an enterprise objective to drive differentiated growth. - Headed the immuno-oncology external combinations team responsible for the development of novel combination therapies with durvalumab or tremelimumab. Initiated 10 Ph1 trials and delivered multiple POC data packages for high priority development targets across indications. Drove the oncology corporate collaboration strategy and established the co-development portfolio with peer pharma companies to accelerate durvaluamb and tremelimumab growth. - Established the durvalumab external research program and held budget accountability. Led the durvalumab CTEP CRADA as the AstraZeneca (AZ) Principle Investigator and co-chaired the NCI-AZ joint steering committee.- Led the global product team for durvalumab development in the Head and Neck indication. Advanced the Ph3 investment decision for KESTRAL, a Ph3 trial of durvalumab +/- tremelimumab in 1L Head and Neck indication. Successfully drove the development strategy, governance interactions, program budget and trial execution.- Served on the AstraZeneca R&D Waltham Site Leadership Team. -
Executive Director, Clinical DevelopmentZiopharm Oncology Sep 2013 - Jun 2014Boston, MaLed the clinical development of an inducible IL-12 gene therapy in glioma and melanoma and drove protocols, investigator brochures, steering committees, annual reports & publication plans. Delivered the Ph1 First-in-Human glioma protocol and achieved a successful review by the NIH Recombinant DNA Advisory Committee (RAC) and subsequently FDA clearance to initiate trial enrollment.
-
Advisor, Late Stage Development & Medical AffairsMerrimack Pharmaceuticals Apr 2013 - Sep 2013Cambridge, MaContributed across the cross-functional matrix to provide enabling support for the MM-398 (nanoliposomal irinotecan) development program. Provided direct project support in the areas of NDA preparation, Ph3 data package readiness, secondary analysis planning, package insert simulation, medication guide scenario planning, and ODAC preparedness. MM-398 received FDA approval in 2015 & is commercialized as Onivyde (irinotecan for injection). -
Medical Director, Medical AffairsInfinity Pharmaceuticals Apr 2012 - Sep 2012Cambridge, MaInitiated the effort to establish the Medical Affairs function and ensure late stage development and commercialization readiness for Saridegib (IPI-926, oral Hedgehog inhibitor), Retaspimycin HCL (IPI-504, HSP90 inhibitor) and Eganelisib (IPI-549, PI3K-gamma). Multiple Ph2 trials failed their endpoints in 2012 and triggered a financial restructure and company-wide layoffs. -
Medical Director, Oncology Us Medical AffairsBristol-Myers Squibb Jan 2011 - Apr 2012Plainsboro, NjLed the US Medical Affairs team and the cross-functional matrix to advance brivanib alaninate, an investigational FGF/VEGF tyrosine kinase inhibitor, through Ph3 development, BLA filing, launch readiness and commercialization. Accelerated the HCC patient journey framework and established the US “Liver Health” campaign, an enterprise partnership to improve outcomes in patients with liver diseases. -
Medical Director, Oncology Global Medical AffairsBristol-Myers Squibb, Princeton, New Jersey Jan 2010 - Apr 2012Accountable for the global medical strategy to support the development of brivanib alaninate. Drove the integration of clinical development and commercialization priorities and devised the global strategy to advance pivotal data disclosure, unbranded liver disease strategy, and engagement of prioritized markets to achieve trial enrollment and launch readiness. -
Associate Director, Oncology Us Medical AffairsBristol-Myers Squibb Jan 2007 - Aug 2010Plainsboro, NjLed the execution of the YervoyTM (ipilimumab) US launch strategy. YervoyTM (ipilimumab), an anti-CTLA-4 monoclonal antibody, was the first FDA approved checkpoint inhibitor for the treatment of malignant melanoma. Headed the ipilimumab data generation strategy and oversaw the Investigator Sponsored Trial program. Drove secondary analyses branching from the ipilimumab Expanded Access Protocol (EAP) and formulated the basis for 2 Ph2 protocols in special populations. Headed the immune-related Adverse Events (irAEs) education and awareness campaign and developed the first ipilimumab Risk Evaluation and Mitigation Strategy (REMS). -
ScientistUmass Chan Medical School Jun 2004 - Jul 2006Worcester, Massachusetts, United StatesPost Doctoral Fellowship, Roger Davis, Ph.D. LaboratoryConducted primary research on JNK / 38 signaling in cancer development and metastasis. Elucidated the cooperativity of JNK and PTEN on the development of prostate adenocarcinoma using inducible mouse models. -
ScientistInstitute Of Cancer Research May 2001 - May 2004Greater London, England, United KingdomPost Doctoral Fellowship, Richard Marais, Ph.D. LaboratoryConducted primary research on oncogenic B-RAF signaling. Discovered siRNA mediated B-RAF silencing results in cellular apoptosis and led the pre-clinical validation of B-RAF as a therapeutic target in melanoma. Discovered TNFa/ NFkB mediated resistance of B-RAF inhibition and established a basis for novel drug combination strategies.
Maria Karasarides, Ph.D. Education Details
-
Leadership And Strategy In Pharmaceuticals And Biotech -
Csu/Cleveland Clinic FoundationBiology, Biochemistry, Cancer Biology -
Cell Biology -
University Of AkronCardiovascular Physiology
Frequently Asked Questions about Maria Karasarides, Ph.D.
What company does Maria Karasarides, Ph.D. work for?
Maria Karasarides, Ph.D. works for Primary Venture Partners
What is Maria Karasarides, Ph.D.'s role at the current company?
Maria Karasarides, Ph.D.'s current role is Science | Drug Development | Healthcare Innovation.
What schools did Maria Karasarides, Ph.D. attend?
Maria Karasarides, Ph.D. attended Harvard Business School, Csu/cleveland Clinic Foundation, Case Western Reserve University, University Of Akron.
Who are Maria Karasarides, Ph.D.'s colleagues?
Maria Karasarides, Ph.D.'s colleagues are Andrew Nadel, Jordan Chernev, Sudha Medapati, Peter Campbell, Sam Gindi, Tshanduko Mudau, Laura Garcia.
Free Chrome Extension
Find emails, phones & company data instantly
Aero Online
Your AI prospecting assistant
Select data to include:
0 records × $0.02 per record
Download 750 million emails and 100 million phone numbers
Access emails and phone numbers of over 750 million business users. Instantly download verified profiles using 20+ filters, including location, job title, company, function, and industry.
Start your free trial