My PhD thesis focused on connecting omics data to marine ecosystems through metabolic modeling. Genome-scale metabolic models allow quantitative and computable genotype-phenotype relationships of target organisms. Yet, models for marine eukaryotic microbes are lagging behind the availability of environmental genomes. My work, combined with top-down techniques, enables fully-automatic reconstruction of eukaryotic-algae metabolic models. 547 models are available this far by applying this new method to Tara Oceans environmental genomes of autotrophic eukaryotes (DOI 10.1101/2023.05.22.541783). This paves the way for an in-depth ecosystemic exploration of plankton communities from viruses to single-cell phototrophs.I graduated with a master's degree in Health Biology (Genetics, Genomics and Systems Biology) in 2019 at Nantes University. I started to be interested in computational biology during an internship about intestinal microbiota in the context of gut-brain-axis pathologies. These new skills allowed me to move forward to microorganisms ecology at the ocean scale.