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Marie Webster is an Assistant Professor at Lankenau Institute for Medical Research. Dr. Webster received her B.A. in Chemistry with a concentration in Biochemistry and Molecular Biology and a minor in Mathematics from Kalamazoo College. She attended graduate school at Johns Hopkins University School of Medicine where she earned her Ph.D. in Pharmacology and Molecular Sciences in 2011. Following graduate school, Dr. Webster worked as a postdoctoral fellow in Dr. Weerartna’s lab where she studied the link between metastatic capacity and the ability of tumor cells to become drug resistant. In 2016 she was promoted to Staff Scientist when she received a K99 Transition to Independence Award. In 2019, Dr. Webster accepted a position as Assistant Professor and started her lab at Lankenau Institute for Medical Research. Dr. Webster currently studies therapy resistance and disease progression in melanoma.
Lankenau Institute For Medical Research
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Assistant ProfessorLankenau Institute For Medical ResearchPhiladelphia, Pa, Us
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Assistant ProfessorLankenau Institute For Medical Research Jun 2019 - PresentDr. Webster is interested in understanding the mechanisms underlying phenotype plasticity that contribute to therapy resistance and disease progression in melanoma. Current projects in her lab include investigating the role of Wnt signaling and slow cycling cells in melanoma progression and epigenetic changes that occur in highly metastatic cells that promote survival following multiple types of stress. Her overall goal is to develop therapeutic strategies to target highly resistant cells. -
Staff ScientistThe Wistar Institute Jul 2016 - Jun 2019PhiladelphiaOverall objective is to understand the role of slow cycling cells in phenotype plasticity of highly resistant metastatic melanoma.• Study the effects of p53 expression in slow cycling and therapy resistance.• Investigate the effects of the aging lung microenvironment on tumor cell proliferation and emergence from dormancy. -
Postdoctoral FellowThe Wistar Institute Oct 2011 - Jul 2016Philadelphia, Pa• Study the link between metastatic capacity and the ability of tumor cells to become resistant to therapy.• Elucidation of the role of Wnt5A and p21 in the DNA damage response.• Investigate the effects of pseudosenescence and DNA damage on invasion and therapy resistance.
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Pharmacology And Molecular Sciences, Ph.D. StudentJohns Hopkins University School Of Medicine 2005 - Oct 2011Baltimore, MdMy thesis project comprised the design and synthesis of cyclic diphosphate prodrugs and bisphosphonate prodrugs. Following successful synthesis of bisphosphonate prodrugs, I evaluated their biological activity against NSCLC. Importantly, my work demonstrated a remarkable enhancement in prodrug activity compared to the parent bisphosphonate in NSCLC. Further studies showed specificity of our clodronate prodrug against melanoma cell lines. My thesis research spanned the spectrum of chemistry to biology and involved a broad range of techniques including NMR, HPLC, mass spectroscopy, human tissue culture, IC50 determination through MTS assay, cell cycle analysis by flow cytometry, and mouse models. -
Post-Baccalaureate FellowNational Institutes Of Health Apr 2004 - Jun 2005Nhlbi, Bethesda, MdI studied the effect of multiple cytokines in drug-induced hepatitis using an acetaminophen-induced liver disease model in mice. I participated in studies to determine the role of cytokines and other factors (including IL-10, IL-6, IL-4, SOCS-3, EC-SOD, HSP-40, IFN-γ, TNF-α) in susceptibility to drug-induced liver disease, using micro array, RT-PCR and immunoblotting techniques. By participating in these studies, I have gained knowledge and experience in drug-induced toxicity, tissue extraction, and signaling pathways involved in inflammation.
Marie Webster Skills
Marie Webster Education Details
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University Of PennsylvaniaBiomedical Postdoctoral Program -
Pharmacology And Molecular Sciences -
Concentration In Biochemistry And Molecular Biology, And Minor In Mathematics
Frequently Asked Questions about Marie Webster
What company does Marie Webster work for?
Marie Webster works for Lankenau Institute For Medical Research
What is Marie Webster's role at the current company?
Marie Webster's current role is Assistant Professor.
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What schools did Marie Webster attend?
Marie Webster attended University Of Pennsylvania, The Johns Hopkins University School Of Medicine, Kalamazoo College.
What are some of Marie Webster's interests?
Marie Webster has interest in Economic Empowerment, Civil Rights And Social Action, Politics, Education, Environment, Poverty Alleviation, Science And Technology, Human Rights, Animal Welfare, Health.
What skills is Marie Webster known for?
Marie Webster has skills like Western Blotting, Fluorescence Microscopy, Immunohistochemistry, Cell Culture, Molecular Biology, Biochemistry, Transfection, Cell Biology, Fluorescence, Confocal Microscopy, Purification, Organic Synthesis.
Who are Marie Webster's colleagues?
Marie Webster's colleagues are James Rapp, Matt Sahayda, Mario Illiano, Msm, Seta Gharadaghian, Kathy Painter, Rosemary Haas, Dennis Shrenk, Ccp.
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Program Manager, Lung Precision Oncology Program (Lpop) Rocky Mountain Regional Veterans Administration Anschutz Medical CampusDenver, Co2riaco.com, covance.com
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