Marieve Dupuis Email & Phone Number

Canada

Montreal, Canada Area

Responsible for PK and PK/PD analyses and reporting using state-of-the-art methods and software. Performs noncompartmental and compartmental PK/PD modeling in various phases of drug development.Performs PK/PD modeling, dose-reponse modeling and statistical analyses according to state-of-the-art methods and regulatory requirements. Collaborate with a team of companies involved in the development of small and large molcules.Apply knowledge and experience in noncompartmental and… Show more Responsible for PK and PK/PD analyses and reporting using state-of-the-art methods and software. Performs noncompartmental and compartmental PK/PD modeling in various phases of drug development.Performs PK/PD modeling, dose-reponse modeling and statistical analyses according to state-of-the-art methods and regulatory requirements. Collaborate with a team of companies involved in the development of small and large molcules.Apply knowledge and experience in noncompartmental and compartmental analysis to investigate dose-reponse population PK/PD relationship to support drug development. Show less

Montréal

• Review clinical and bioanalytical data, perform PK analyses, interpret results and incorporate the findings in high quality reports for FDA, EMA, Health Canada or ANVISA.• Participation in the review process of new protocols to ensure that the study plans will allow achievement of PK objectives and to ensure general scientific quality.• Author of statistical analysis plan in collaboration with biostatisticians.• Participation in the generation of new template with Phoenix®… Show more • Review clinical and bioanalytical data, perform PK analyses, interpret results and incorporate the findings in high quality reports for FDA, EMA, Health Canada or ANVISA.• Participation in the review process of new protocols to ensure that the study plans will allow achievement of PK objectives and to ensure general scientific quality.• Author of statistical analysis plan in collaboration with biostatisticians.• Participation in the generation of new template with Phoenix® WinNonlinTM for generation of PK tables and figures for rapid generation of high quality reports, improving timing metrics for clinical pharmacology deliverables.• Responsible of practical training sessions for peer colleagues on Phoenix® WinNonlinTM.• Report lead roles with specific tasks: ensure that project timelines are met, ensure that documents delivered to customers meet their expectations, and ensures the link between the clinical pharmacology department and other departments Show less

Drug Discovery Support, Biological Sciences,Boehringer Ingelheim Canada Ltd• Planned and executed all surgical procedures required for oral and intravenous automated pharmacokinetic (PK) studies in rodents. Performed raw data analysis, calculation of PK parameters and reported results to project teams to enable rapid identification of compounds with high potential.• Performed and taught various cannulation techniques in rodents (carotid, jugular vein and common bile… Show more Drug Discovery Support, Biological Sciences,Boehringer Ingelheim Canada Ltd• Planned and executed all surgical procedures required for oral and intravenous automated pharmacokinetic (PK) studies in rodents. Performed raw data analysis, calculation of PK parameters and reported results to project teams to enable rapid identification of compounds with high potential.• Performed and taught various cannulation techniques in rodents (carotid, jugular vein and common bile duct).• Evaluated, validated and recommended an automated PK samplers model allowing unattended sampling, leading to improved data quality, reduced animal stress and number study repeat improving efficiency of lead identification.• Established a micro-sampling technique in mice to improve data quality and reduce number of animals (full profile per animal). Participated to the redaction and/or revision of SOPs (rodent surgeries and post approval monitoring).• Developed oral formulations for lead compound to optimize exposure and enable toxicology and general pharmacology studies.• Created and maintained database for correlation analysis between in vivo and in vitro ADME PK parameters.• Responsible for robotised Caco-2 permeability assay on workstations (Seed and Feed: Hamilton and assay: TECAN) data analysis, interpretation and reporting.• Diagnosed and troubleshot robotic issues and problems on various ADME robotic platforms (ABS, TECAN and Hamilton).• Performed protein binding studies using equilibrium dialysis, incubation, extraction, HPLC or LC/MS/MS data analysis, data interpretation and reporting.• Trained students and new employees in the in vivo group.• Appointed as ADME-PK representative in the WHMIS group for the implementation of the new labelling system policy. Show less

Master'S Degree, Pharmacology

Master Degree, Pharmacology

Role of the NADPH-reductase in the diminution of CYP3A6 during an inflammatory reaction Rabbit hepatocytes isolation (primary culture)..

Bachelor Degree, Biomedicals Sciences