• Management, lead and coordination of international customer projects for target trace analysis like genotoxic impurities (GTI) using state-of-art analytical technologies, from customer request to delivery of results, including customer relationship management.• Main point of contact, advising customers on technical aspects of analytical projects• Management of all Occupational hygiene orders and requests (routine and method development)• Collaboration with all involved Solvias department in customer projects• Management of laboratory planning• Plan, design, and execute method development or transfer of analytical methods using hyphenated technologies.• Compilation and review of analytical documentation. protocols, reports, certificates of analysis• Data review, processing, and management of OOS/OOE/OOT, deviation, change control and customer complaints.• Ensuring compliance with GMP requirements• Trigger and lead of troubleshooting activities, supporting colleagues in technical issues.

• Managing design, development, validation, and transfer in production of analytical methods (LC-MS and GC-MS), including the creation of control charts to ensure quality of results across time, machine, and resources. Compilation, interpretation and communication of complex scientific data and creation of innovative experimental solution• Leading investigations of results non-conformance in production, from root cause analysis to implementation of corrective and preventive action in production• Collaborating between different departments to keep all projects running efficiently and on target. • Reporting technical advancement and project status e.g, timelines, risks, and opportunities • Communication with internal and external stakeholders on analytical methods• Leading documentation preparation and technology transfer to production• Training of technicians (production and R&D) on developed analytical methods, state-of-art analytical technologies, and risk awareness.• Participation to investments and budget of the R&D team

Revealing the hidden face of bacterial metabolism in Acinetobacter baylyi ADP1• Creation of a production and extraction protocol with big scale bacteria culture• Purification: Process development for the purification of interest metabolite from extracted intracellular metablism, by preparative HPLC, and HPLC-MSn.• Structural Elucidation of the unknown metabolite by LC-MSMS (Thermo LC-MSn, Orbitrap Elite) and NMR (Brücker, RMN 600 MGHz withe cryoprobe)• Creation of a high throughput analysis method for 2600 metabolomes screening: culture, extraction, HPLC-MSn, data analysis (statistics).• Determination of bacterial biosynthesis pathway• Participation to lab communication in the department and externally (conferences, student training…)De novo structure determination of 3-((3-aminopropyl)amino)-4-hydroxybenzoic acid, a novel and abundant metabolite in Acinetobacter baylyi ADP1, Thomas, 2016

Internship (6 months) in Biocheistry Lab (Pr VanPee) for my double diplomaRegioselective halogenation reaction study:- Production and purification of the enzyme- Optimization and caracterisation of halogenation reaction- Extraction and purification of reaction product- Structural elucidation by NRMStage effectué au sein du Laboratoire de Biochimie du Pr. Van Pée dans le cadre de mon double diplôme à l'Université Technique de DresdeÉtude d'un réaction d'halogénation régiosélective du tryptophane. - Production et purification de l'enzyme - Caractérisation et optimisation (scale up) de la réaction d'halogénation - Extraction et purification d'un composé formé (HPLC préparative) - Élucidation structurale de la molécule (RMN)

Intership (4 months) in Bioanalytic lab, (Pr Bünner)Protocol optimisation for amino acid extraction in sponge skeletons (Aplysina cavernicola and Ianthella basta) for composition study by GC-MS ou UV-Vis.Stage de recherche effectué au sein du laboratoire de Bioanalytique du Pr. Brünner de l'Université Technique de Dresde. Optimisation d'un protocole pour l'extraction d'acide aminés de squelette d'éponges (Aplysina cavernicola and Ianthella basta) pour l'étude de la composition de ceux-ci par GC-MS ou UV-Vis.

Bacterial metabolism study by metabolomic approaches1 - Unknown metabolite study by LC-MSn (LTQ-Orbitrap) : fragmentations study2- Study of metabolic biosynthesis pathways used by bateria to produce observed unknown metabolites.Kinetoc study of metabolite synthesis (isotopic)Genomic sequences comparisons.Étude du métabolisme bactérien par des approches métabolomiques1 - Étude d'un métabolite inconnu de la bactérie par LC-MSn (LTQ-Orbitrap) afin d'obtenir un maximum d’informations structurale sur la molécule (fragmentations)2- Étude des voies métaboliques utilisées par la bactérie pour la synthèse des métabolites inconnusÉtude de la cinétique de formation de certains métabolites (marquage isotopique)Comparaison de séquences génomiques avec MaGe (Microbial Genome Annotation Analysis Platform)

Sample analysis for lead analysis by Atomic Absorption Spectrometry (AAS)Sample reception and registration in LIMSAnalyse d'échantillons d'eaux pour le dosage de plomb Spectrométrie d'Absoption Atomique (SAA)Réception et codage des échantillons