Mark Benton

Mark Benton Email and Phone Number

CTX110/CTX112 Program Leader and Head of Clinical Pharmacology @ CRISPR Therapeutics
Mark Benton's Location
Greater Boston, United States, United States
Mark Benton's Contact Details

Mark Benton work email

Mark Benton personal email

About Mark Benton

· Clinical scientist with nearly 15 years of research experience, including 5 years in the pharmaceutical industry.· In-depth knowledge of oncology clinical trial methodology: protocol authorship, regulatory submissions, site and monitor training, study oversight, database management, data analysis, and manuscript/CSR preparation.· Contributing member of cross-functional drug development asset teams, including launch-readiness experience.

Mark Benton's Current Company Details
CRISPR Therapeutics

Crispr Therapeutics

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CTX110/CTX112 Program Leader and Head of Clinical Pharmacology
Mark Benton Work Experience Details
  • Crispr Therapeutics
    Vice President, Program Leadership
    Crispr Therapeutics Jul 2023 - Present
    Boston, Ma, Us
  • Crispr Therapeutics
    Executive Director, Clinical Development And Pharmacology
    Crispr Therapeutics Jan 2022 - Jun 2023
    Boston, Ma, Us
  • Crispr Therapeutics
    Senior Director, Clinical Development
    Crispr Therapeutics Jan 2020 - Dec 2021
    Boston, Ma, Us
  • Crispr Therapeutics
    Director, Clinical Development Scientist
    Crispr Therapeutics Jan 2019 - Dec 2019
    Boston, Ma, Us
  • Crispr Therapeutics
    Associate Director, Clinical Development Scientist
    Crispr Therapeutics Apr 2018 - Jan 2019
    Boston, Ma, Us
  • Shire
    Associate Director - Clinical Development Scientist
    Shire Mar 2017 - Mar 2018
    Tokyo, Jp, Jp
  • Abbvie
    Senior Associate Clinical Scientist I
    Abbvie May 2015 - Mar 2017
    North Chicago, Illinois, Us
    · Primary protocol author and clinical lead for Phase 1/2 study of veliparib and nivolumab in NSCLC · Key contributor to the clinical strategy and FIH study design for EGFR ADC program· Authored essential documents for China FDA submission of Phase 2/3 1L study of ABT-414 in GBM· Provided scientific oversight for veliparib CTEP and IIS programs
  • Abbvie
    Associate Clinical Scientist Ii
    Abbvie Mar 2014 - May 2015
    North Chicago, Illinois, Us
    · Clinical lead for Phase 2 study of veliparib and FOLFIRI in metastatic colorectal cancer· Trained monitors and study team members; conducted site training visits and virtual investigator meetings· Built meaningful relationships with investigators and external experts; held 20+ face-to-face meetings at ASCO and ASCO GI · Authored critical study documents including site and reugulatory correspondence, DMC charter and interim analysis plan, study newsletters, etc.·Collaborated with commercial development to build positioning, messaging, and branding platform for veliparib
  • Abbvie
    Senior Scientist
    Abbvie Dec 2011 - Dec 2013
    North Chicago, Illinois, Us
    · Implemented hippocampal and spinal cord slice electrophysiology into the CNS and pain discovery strategy· Generated mechanism of action data for multiple ion channel discovery programs · Interrogated effects of lead compounds on distinct components of network signaling, e.g. spontaneous and evoked synaptic transmission, short- and long-term synaptic plasticity, and action potential firing properties· Characterized potency, selectivity, and kinetics of lead compounds in native and recombinant tissue · Supported SAR for ion channel programs using automated electrophysiology for both on- and off-target isoforms
  • Abbott Laboratories
    Biologist Iv
    Abbott Laboratories Aug 2011 - Dec 2011
    Abbott Park, Illinois, Us
    • Performed hit-to-lead assays of novel chemical matter against ion channel targets using IonWorks Barracuda• Validated data using manual and automated electrophysiology including QPatch, PatchXPress, and FLIPR platforms
  • Abbott Laboratories
    Summer Intern
    Abbott Laboratories Jun 2011 - Aug 2011
    Abbott Park, Illinois, Us
    • Developed high-throughput electrophysiological assays for voltage- and ligand-gated channels on IonWorks Barracuda• Cultured stable and transiently transfected HEK 293 and CHO cell lines expressing voltage- and ligand-gated channels
  • Northwestern University
    Graduate Student
    Northwestern University Sep 2006 - Dec 2011
    Evanston, Il, Us
    • Interrogated ion channel modulation and pharmacology using patch-clamp electrophysiology• Characterized relationship between SK channel activity and the intrinsic firing frequency in cerebellar Purkinje cells• Expert in whole-cell current- and voltage-clamp recording from acutely dissociated neurons• Experienced with brain and retinal slice recording, two-photon microscopy, Ca imaging, and laser uncaging
  • Wayne State University
    Research Assistant
    Wayne State University Mar 2004 - Aug 2006
    Detroit, Mi, Us
    • Utilized functional and structural MR imaging to study cortical circuits implicated in psychiatric illness• Designed experiments, acquired and analyzed data that produced 3 scientific articles and 8 conference abstracts• Taught two day training program covering MRI data analysis to 15 PhD and MD faculty members.• Won research assistant poster presentation award at the Michigan Society for Neuroscience meeting
  • University Of Michigan
    Research Assistant
    University Of Michigan Sep 2002 - Aug 2003
    Ann Arbor, Michigan, Us
    • Created a computerized system for psychological evaluations which eliminated hand-scoring and manual data entry

Mark Benton Skills

Electrophysiology Neuroscience Pharmacology Cell Culture Ion Channels Assay Development High Throughput Screening Cell Biology Clinical Development Fmri Immunohistochemistry Physiology Confocal Microscopy Clinical Trials Oncology Clinical Research Clinical Study Design Data Analysis Drug Development

Mark Benton Education Details

  • Northwestern University
    Northwestern University
    Neuroscience
  • University Of Michigan
    University Of Michigan
    Biopsychology And Cognitive Science

Frequently Asked Questions about Mark Benton

What company does Mark Benton work for?

Mark Benton works for Crispr Therapeutics

What is Mark Benton's role at the current company?

Mark Benton's current role is CTX110/CTX112 Program Leader and Head of Clinical Pharmacology.

What is Mark Benton's email address?

Mark Benton's email address is md****@****ail.com

What schools did Mark Benton attend?

Mark Benton attended Northwestern University, University Of Michigan.

What skills is Mark Benton known for?

Mark Benton has skills like Electrophysiology, Neuroscience, Pharmacology, Cell Culture, Ion Channels, Assay Development, High Throughput Screening, Cell Biology, Clinical Development, Fmri, Immunohistochemistry, Physiology.

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