Zhiqiang (Mark) H.

Zhiqiang (Mark) H. Email and Phone Number

Principal Scientist | Data Scientist @ Alcon
Dallas, TX, US
Zhiqiang (Mark) H.'s Location
Dallas, Texas, United States, United States
Zhiqiang (Mark) H.'s Contact Details

Zhiqiang (Mark) H. work email

Zhiqiang (Mark) H. personal email

n/a
About Zhiqiang (Mark) H.

I received a PhD in Biophysics and have amassed over 14 years of experience in academia, pharmaceuticals, and biotechnology.I specialize in integrating biochemistry, material science, and data science to enhance drug discovery and medical device development. My career is defined by a deep commitment to transforming hypotheses into actionable therapeutic strategies through innovative bioanalytical methodologies and computational models.Expertise in Drug Discovery: My background features robust experience in translational research and biomarker discovery, where I have led cross-functional teams to develop groundbreaking therapies for conditions ranging from Alzheimer’s to cancer. I excel in designing and executing bioassays and have a proven track record in advancing drugs from conception through to clinical trials, ensuring regulatory compliance and efficacy at every stage.Data Science Proficiency: I am adept at harnessing the power of machine learning and predictive modeling to enhance drug development processes. My technical arsenal includes advanced proficiency in Python, machine learning frameworks such as TensorFlow and Scikit-Learn, and big data platforms. I leverage these tools to refine drug targets, optimize therapeutic indices, and predict treatment outcomes, significantly reducing both time and cost to market.Collaborative Leadership: Throughout my career, I have cultivated strong collaborative ties with industry professionals, academicians, and clinical researchers, fostering environments that encourage innovation and knowledge sharing. My work has not only led to successful project outcomes but has also been recognized in high-impact scientific publications and patent filings.I am passionate about the intersection of technology and healthcare and am continually seeking opportunities to develop therapies that promise not just better outcomes but also accessible care.

Zhiqiang (Mark) H.'s Current Company Details
Alcon

Alcon

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Principal Scientist | Data Scientist
Dallas, TX, US
Website:
alcon.com
Employees:
26800
Zhiqiang (Mark) H. Work Experience Details
  • Alcon
    Principal Scientist | Data Scientist
    Alcon
    Dallas, Tx, Us
  • Alcon
    Principal Scientist
    Alcon Aug 2021 - Present
    Geneva, Switzerland, Ch
    • Led cross-functional teams in Pre-clinical, Advanced Device Analysis, and Analytical Chemistry to support Marketing, R&D Devops, and Corporate legal teams at Alcon.• Expertise in Data Collection, Cleaning, Pre-process, EDA, Modelling, Evaluation, Visualization, deployment, and Communication with stakeholders.• Achieved successful practical business problem-solving through collaboration and innovative data-driven solutions.
  • Ut Southwestern Medical Center
    Faculty Instructor
    Ut Southwestern Medical Center Jun 2017 - Jul 2021
    Dallas, Texas, Us
    • Chan-Zuckerberg Initiative-Funded Alzheimer's Research: Led a pioneering project to predict and validate early-stage drug targets in Alzheimer's disease. Utilized a combination of biophysics, structure biology, protein engineering, big omics data analytics, AI-driven tools to identify potential drug target, significantly advancing our understanding of disease mechanisms.• Innovative Bioassay Development: Directed the validation of novel biomarkers using Biosensor cell assays, immunoassays, Biacore, ThT aggregation, simulation techniques, Cryo-EM structural analysis, SAXS “small angle x-ray scattering”, and other advanced analytics platforms. Authored two high-impact publications in Nature Communications and filed a U.S. Patent, showcasing the potential of these biomarkers in predicting Alzheimer's disease progression and treatment efficacy.• Educational Leadership and Mentorship: Played a crucial role in educating and training undergraduate and postdoctoral researchers. Contributed as a reviewer for several prestigious scientific journals and served as an editorial board member for the American Journal of Biotechnology and Bioinformatics since September 2017.
  • Ut Southwestern Medical Center
    Postdoctoral Researcher, Biophysics
    Ut Southwestern Medical Center Nov 2013 - May 2017
    Dallas, Texas, Us
    • Conducted pioneering research in molecular, biochemical, structural, and cell biology to elucidate the regulatory mechanisms of the circadian clock, with implications for metabolic disorders.• Utilized cutting-edge NMR and X-ray crystallography techniques to guide and validate biomarker gene mutations for cellular timekeeping and metabolic regulation.
  • Techlent
    Senior Data Scientist
    Techlent Aug 2020 - Mar 2021
    San Francisco, Ca, Us
    Detection System Development: Developed a fraud detection system to minimize financial losses by avoiding fraudulent claims. Conducted comprehensive exploratory data analysis, feature engineering, and feature selection on extensive customer data sets. Developed robust binary classification models, including Logistic Regression, Random Forest, XGBoost, and Decision Tree. Enhanced the efficacy of the XGBoost model through strategic approaches such as stratified sampling, SMOTE, and GridSearchCV, coupled with hyperparameter tuning to correct dataset imbalances. Achieved a precision of 0.85 and an ROC_AUC of 0.92. Integrated the model into an interactive API using Flask and deployed it to Google Cloud Platform (GCP).
  • Pharmaron
    Project Team Leader
    Pharmaron Nov 2011 - Oct 2013
    Beijing, Cn
    • High-Throughput Drug Screening project for Merck, performing advanced data analytics to evaluate therapeutic efficacy. Delivered insightful presentations on project outcomes, influencing drug development strategies.• Next-Generation Sequencing and Cancer Mutation Analysis: Led the development and implementation of a next-generation sequencing platform, Proton, to establish robust cancer detection protocols. Built a comprehensive statistical framework for SNP calling and mutagenesis analysis. Collaborated with Guangdong Province Renmin Hospital to identify cancer gene mutations, enhancing treatment personalization.• 3D Cell Culture Development: Developed 3D cell culture techniques for cancer stem cell spheroid culturing, significantly enhancing the efficacy of patient-derived xenograft (PDX) mouse models used in translational cancer research.
  • Pharmarcy College At University Of Toledo
    Visiting Scholar
    Pharmarcy College At University Of Toledo Jan 2009 - Jul 2009
    Drug metabolism

Zhiqiang (Mark) H. Skills

Computational Biology Phoenix Stem Coding Experience Git Network Virtualization Application Deployment Nlp Amazon Web Services Cell Biology Classification Scanning Electron Microscopy Virtual Networks Data Analysis Tensorflow Pca Clustering Time Series Forecasting Protein Engineering Deep Learning Tableau Nltk Amazon Ec2 Relion3.1 Statistical Data Analysis Cloud Administration Ccp4i Implantable Medical Devices Jupyter Notebook Matplotlib Storage Solutions Drug Discovery Molecular Biology Google Cloud Platform Identity And Access Management Polymer Structure Coot Data Modeling Apache Spark Unit Tests Network Security Docker Aws Auto Scaling Biophysics X Ray Crystallography Computer Vision Xgboost Flask Databases Medical Device R&d Sql Python Technical Solution Design Nmrpipe Rosetta Machine Learning Svm Data Visualization Xquest Protein Structure Prediction Random Forest Tem Imaging

Zhiqiang (Mark) H. Education Details

  • University Of Chinese Academy Of Sciences, Institute Of Biophysics
    University Of Chinese Academy Of Sciences, Institute Of Biophysics
    Bioinformatics

Frequently Asked Questions about Zhiqiang (Mark) H.

What company does Zhiqiang (Mark) H. work for?

Zhiqiang (Mark) H. works for Alcon

What is Zhiqiang (Mark) H.'s role at the current company?

Zhiqiang (Mark) H.'s current role is Principal Scientist | Data Scientist.

What is Zhiqiang (Mark) H.'s email address?

Zhiqiang (Mark) H.'s email address is zh****@****abs.com

What schools did Zhiqiang (Mark) H. attend?

Zhiqiang (Mark) H. attended University Of Chinese Academy Of Sciences, Institute Of Biophysics.

What skills is Zhiqiang (Mark) H. known for?

Zhiqiang (Mark) H. has skills like Computational Biology, Phoenix, Stem, Coding Experience, Git, Network Virtualization, Application Deployment, Nlp, Amazon Web Services, Cell Biology, Classification, Scanning Electron Microscopy.

Who are Zhiqiang (Mark) H.'s colleagues?

Zhiqiang (Mark) H.'s colleagues are Noe Mercado, Shays Shays, Krishnasamy Thamilarasan, Kelly Jefferson, Aboc, Arthur Neng, Juwana Love, Matt Zadeh.

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