Mark Evans Email & Phone Number

California, United States

California, United States

Madison, Wisconsin, Us

Madison, Wisconsin, Us

My team of Bioinformatics Data Engineers and I strive to provide ETL and analytical support for Commercial, Clinical and Process Engineering data pipelines for Lab Developed qPCR Tests and In vitro diagnostic devices (IVD). Currently deeply involved in software development activities to support new product development for multiple NGS-based cancer screening panels (liquid and solid tumor), as well as IVD development for various qPCR platforms. Implementing technology infrastructure utilizing AWS, Python, JupyterHub, R Shiny, Apache Zeppelin, MSSQL, Tableau, Docker and Django.

Emeryville, Ca, Us

https://www.abalonebio.com/Abalone is shifting the paradigm for antibody development, isolating drug candidates directly by their modulating effects on integral membrane proteins. Abalone is an early stage biotech start-up in the San Francisco Bay Area. We are partnering with leading academic labs, targeting G protein-coupled receptors (GPCRs) and ion channels. Our drug development programs address unmet needs in oncology, inflammation and pain sensation.

https://www.kotai-bio.com/High-throughput structural modeling and analysis platform for immune cell sequences derived from patient blood samples, revealing the structure and function of immune cell receptors with unprecedented resolution.

Redwood City, Ca, Us

Located within the Product Services R&D division of GHI, my team of Data Engineers and I strive to provide ETL and analytical support for Commercial, Clinical and Process Engineering data pipelines for Lab Developed qPCR Tests and In vitro diagnostic devices (IVD). Currently deeply involved in software development activities to support new product development for a cancer IVD on the Biocartis Idylla qPCR platform. Implementing technology infrastructure utilizing JupyterHub, R Shiny, Apache Zeppelin, MSSQL, Tableau, Docker and Django.

Emeryville, California, Us

After a 3 year hiatus, during which Xoma underwent a significant workforce restructuring, brought back to re-establish the Bioinformatics function by hiring two people.• Significantly reduced data integrity errors, while providing more workflow flexibility and an improved UI/UX interface by redesigning the integrated assay LIMS and sequence analysis software. Consequently, this software won the BioIT World Best Practices Editors Choice Award in 2016 ( http:// goo.gl/mP2m0h ).• Developed an NGS analysis pipeline for Ion Torrent™ data that was able to identify 1000x more potential antibody candidates from a single experiment.• Significantly enhanced protein modeling capabilities by licensing software from the University of Oxford and integrating it with open-source tools to create an automated antibody 3D-structure prediction pipeline.• Initiated a research program that took some existing assets with no current value and explored their utility in a new HIV indication. Succeeded in demonstrating activity and provided Business Development with a new, valuable asset for less than a $100K investment.• Developed technology innovation strategic plan for the Discovery Research department. Identified outside consulting agency to work with as a partner to map out existing processes and workflow, identify equipment utilization patterns and develop long-term proposal for improvement• Re-implemented software code lifecycle management platform on GitHub• Participate as team member on company-wide IT governance committee

South San Francisco, California, Us

Monogram is the largest and most respected HIV testing company in the world, with their genetic tests providing the gold standard. Mining their patient database for HIV mutation trends and characteristics in response to pharmaceutical company queries was always a fascinating exercise. • Developed a novel software algorithm to predict the co-receptor tropism of HIV1 based upon DNA sequence with an overall concordance rate of more than 81% when compared to existing enhanced sensitivity Trofile® phenotypic assay which was incorporated in a new diagnostic test product.• Developed an XML Rule Engine that assesses patients HCV genotype and determines drug resistance which formed the core of the new HCV GenoSure® NS3/NS4A drug resistance assay product.• Developed software to perform in silico antibody epitope mapping on HIV targets with high accuracy, resulting in a published patent, publication in BMC Bioinformatics in 2014 and a poster presentation at the AIDS Vaccine conference in 2012.

Emeryville, California, Us

Brought to establish the Bioinformatics function initially as a Sr. Scientist. Ultimately hired 3 software engineers and together created LIMS and scientific analysis capabilities for Discovery Research that allowed for the first time, true knowledge management abilities, standardization of analysis methods and allowed the researchers to move beyond using Excel for everything.• Created web-based integrated assay LIMS / DNA analysis software that reduced analysis time per assay from weeks to minutes and allowed a 10x increase in the number of antibodies that could be screened and a 3x increase in the number of drug targets that could be evaluated per year.• Implemented the manual algorithm for antibody human engineering in software, was able to reduce the lead time to engineering start from 1 month to 1 day, increasing capacity by 30%.• Designed and wrote several LIMS systems for use by various functional groups to manage scientific data and analysis during antibody discovery, batch records for antibody production and freezer inventory management. Developed custom antibody DNA and protein sequence analysis software.• Member of Translational Medicine task force working to identify potential biomarkers for late stage antibody discovery projects. Worked closely with collaborators to design, analyze and interpret genomics and proteomics experiments to support this goal.• Worked with Legal on FTO analyses for discovery programs and for I.P. filing. Supported Legal with technology evaluations.• Assisted Business Development to close 3 Technology Collaboration deals of which internally developed software was a component with Takeda SF, Arana Therapeutics, and Kaketsukan totaling $46 Million in 2009.

Us

Managed two programmers and created a module for their LIMS system that managed FACS data using LAMP stack

Leverkusen, North Rhine-Westphalia, De

• Supported Affymetrix microarray analysis, including designing a custom chip for use at Bayer• Developed custom LIMS system that resulted in $300K saving and a special recognition award• Created Oracle data warehouse that integrated public and private data sources with a web-based UI, resulting in a Scientific Achievement award• Developed a web interface for a commercial Oracle-based LIMS, which dramatically improved user adoption and salvaged the company’s investment of more than $400K

• Develop custom GUI/data analysis modules for Company’s Visual Genome product. Modules, written in Perl/Tk, are rapidly developed in response to customer requests/ feedback. The product uses a MySQL database.

Waltham, Ma, Us

• Significantly redesigned and improved legacy clone tracking database systems for high throughput cloning team, resulting in increased efficiency and decreased product defects.• Developed software and methods for identification of full-length genes in various genomes from public databases• Generated scientific data regarding company products for use by Marketing & Technical Service departments.• Assisted in developing corporate website

Waltham, Ma, Us

Waltham, Ma, Us

La Jolla, Ca, Us

• Design and prepare course materials. Teach introductory course consisting of 2 full-day seminars. Assist students with computer lab tasks. Administer and grade exams.

La Jolla, Ca, Us

M.S., Biochemistry

B.S., Biochemistry & Cell Biology