Mark Depristo Email & Phone Number

Los Altos, CA, US

San Mateo, California, US

BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective.

South San Francisco, California, US

Developer of a medical platform intended to make pregnancy safe by delivering insights to moms and families. The company's offerings include predictive tests and pregnancy management, enabling patients to identify at-risk pregnancies and facilitating new therapeutic approaches.

Austin, Texas, US

Developer of testing kits intended to provide access to transparent and insightful lab tests. The company develops do-it-yourself kits for a wide range of at-home regulatory-compliant diagnostic tests including food sensitivity, fertility, hormones, STDs, thyroid and metabolism among the others, enabling users to perform tests at home and receive.

Mountain View, CA, US

I created and led the Genomics team in Google Brain where we apply deep learning technologies to problems in genetics and genomics. We created two open-source software packages: DeepVariant, variant caller using convolutional neural networks and the top starred repository in genomics on GitHub, and Nucleus, a library for reading and writing genomics data.

Mountain View, CA, US

- Create software tools to analyze life sciences data (genomics, devices, clinical records) to make medicine more proactive and less reactive.- Apply Google technologies to life science problems, including Brain and TensorFlow, BigQuery, Flume and MapReduce, Google Cloud Platform and Borg.- Build scalable software systems using Python, C++, and Java to.

• Member of the executive management team at an early-stage biotechnology startup developing molecular diagnostics for Autism
• Responsible for crafting strategy and tactics, budgeting; intellectual property; partnerships, and scientific collaboration; fund-raising; interaction with the Board of Directors, SAB/CAB, vendors, and key-opinion.
• Developing a machine learning toolkit for biomarker discovery in Python
• Developing cloud-based software under an FDA quality system to manage company infrastructure (storage, compute, and security) and execute EC2 workflows for next-generation sequencing data
• Helping design and execute a 880 subject FDA-compliant clinical trial (STORY NCT01810341)
• Responsible for all analyses of molecular (metabolomics, RNA-seq, exome sequencing, microarrays, copy-number variation) and clinical data for STORY clinical trial

Cambridge, MA, US

• Managed a team of 15 computational biologists and software engineers
• Promoted three times in five years from individual contributor to program co-director with leadership responsibilities across hundreds of employees and academic contributors
• Principal Investigator overseeing the development of analytic methods and technologies for next-generation DNA sequencing (NGS) in medical genetics
• Conceived of and implemented the Genome Analysis Toolkit (GATK), the standard package for data processing and analysis of next-generation DNA sequencing data, used >100,000 times each day throughout the world
• Leader in many international research consortia (such as the 1000 Genomes Project) applying NGS to answer fundamental questions about human genetics and disease
• Widely published in the scientific literature; spoke at dozens of international conferences on DNA sequencing and human genetics

Boston, MA, US

Provided business strategy to biotechnology, pharmaceutical, medical device, and private equity companies based on qualitative and quantitative analyses of markets, competitors, and customers

Cambridge, Massachusetts, US

Investigated five point mutations in beta-lactamase that jointly increase resistance to an antibiotic by approximately 100,000 fold

Boston, MA, US

Visiting postdoc in James Collins lab at BU working on the evolution and mechanism of antibiotic killing

Ph.D., Biochemistry

Ba, Mathematics And Computer Science