Jiyuan (Mark) Ma Email & Phone Number

Cranbury Township, NJ, US

South Plainfield, New Jersey, United States

Drug metabolism and pharmacokinetics to support drug discovery and development

• Biotransformation in support of drug development programs: human ADME studies and prediction of DDI potentials, preclinical mass balance and ADME studies, and human dosimetry prediction from tissue distribution (QWBA).
• Metabolite profiling and identification for in vitro and in vivo ADME studies by LC/MS.
• Reaction phenotyping, enzyme inhibition and enzyme kinetic studies.
• Discovery bioanalysis by LC/MS in support of in vitro drug metabolism.

• Project management.
• Metabolite profiling and identification for in vitro and in vivo ADME studies by LC/MS.
• Exploratory bioanalysis by LC/MS in support of discovery DMPK.
• Isolation and identification of drug metabolites, drug impurities or degradation products using LC/MS and NMR.

• Natural product research and development.
• Qualitative and quantitative chemical analysis of active natural products by LC/MS and NMR.

NIH funded chemical and biological research on botanical dietary supplements (OD-99-007).

Isolation and structural elucidation of sesquiterpene lactones with anti-tumor activity from Ixeris sonchifolia.