Mark Sena Email & Phone Number

Redwood City, Ca

Extracting company- and customer-facing insights from biometric signals and app usage data

Palo Alto, Ca

Recognition of physical activities using Athos smart clothing (embedded EMG-sensors)● Engineered a feature set to quantify dynamic muscle activity from 8-D time series● Built models (SVM, Random Forest) to classify 5 different physical activities with 86% accuracy● Produced a source-code-linked report describing my approach and results (marksena.me/insight/blog-post)

San Francisco Bay Area

Research­ grade movement analysis for sports­ medicine professionals and patients● Spun out a 3­D motion analysis company based on graduate work with the Kinect● Wrote a winning SBIR / STTR grant for the company● Led team to win the “I​dea to IPO”​ business plan competition (Steve Burrill)● Conducted >100 consumer interviews during the "L​ean Launchpad"​ (Steve Blank)● Won "B​est App for Patients and Healthcare Professionals"​ at Hacking Health

San Francisco Bay Area

Low­-cost 3­D movement analysis using the Microsoft Kinect and retro-reflective markers● Invented a method for tracking the position of anatomical markers using the Kinect● Developed an OO framework in MATLAB for processing data streaming at 1.3 Gb/min● Implemented computer vision algorithms for segmentation and labeling of markers● Tracked anatomical joints with 10x greater accuracy than Microsoft’s markerless method● Produced a provisional patent for a 3­D motion tracking system using infrared markersMethod and apparatus for quantitative assessment of dynamic knee joint stability● Invented a mechanical device for automating the “P​ivotShift” ​test for ACL injury● Increased the repeatability and inter­-examiner reproducibility of the test by >10­-fold● Extracted knee stability metrics from streams of 6­D force and motion data at 100 Hz● Used ANOVA and logistic regression to explain differences between ACL reconstructions● Produced two 1st author papers and one patent for a mechanical device to evaluate joints

San Francisco Bay Area

The effect of insulinoma cell cluster size on C-peptide expression• Microfabricated PDMS stamps for microcontact printing of laminin protein• Chemically modified glass surfaces for controlled culture and patterning of insulinoma cells • Performed 4-color staining and spinning-disk confocal imaging to quantify C-peptide expression

San Francisco Bay Area

Hacking the Agilent 2100 Bioanalyzer as a power supply• Configured, tested, and troubleshooted “lab-on-a-chip” micro-electrophoresis equipment• Wrote a manual and developed protocols for custom use of the 2100 instrument

San Francisco Bay Area

Engineered phage-based piezoelectric materials• Generated a new class of periodically-aligned self-assembled phage film microstructures (later published in Nature)• Amplified and sequenced genetically engineered M13 phage in e. coli for materials applications

Greater Seattle Area

Applications of Nanotechnology in Medicine• Developed a microbead-based microfluidic assay for fluorescence detection of HIV nucleic acids • Prepared fluorescent quantum dots for disease diagnostics, medical imaging, and drug delivery• Characterized nanoparticles via fluorescence microscopy, spectroscopic, and particle-sizing techniques

Greater Seattle Area

A Quantum Dot-Based Microfluidic Immunoassay• Improved the sensitivity of an existing fluorescence-based protein assay using quantum dots• Implemented the assay in a microfluidic platform for sample loading and optical quantitation• Performed fluorescence microscopy, multispectral and surface plasmon resonance imaging• Designed and built microfluidic chips using poly-laminate plastics and AutoCAD software

Greater Seattle Area

Silica-based HIV RNA extraction for point-of-care viral load testing • Characterized currently available products for viral RNA extraction from human serum• Identified and tested alternative, low cost materials for in-house RNA extractions• Designed and tested a filter unit for RNA extractions without the use of a centrifuge

Doctor Of Philosophy (Phd), Bioengineering And Biomedical Engineering

Bachelor Of Science (B.S.), Bioengineering And Biomedical Engineering