Founder of a consulting firm offering drug discovery and preclinical development guidance. Roles include project selection and portfolio oversight, medchem problem solving, rational drug design, computational chemistry, process R&D, value proposition assessment, due diligence, fund raising, patent strategy and documentation, CRO management, project planning and leadership to execute in short time frames. Helped drive 5 projects through candidate nomination and preclinical development, and progressed lead optimization for an additional 12. Cited as inventor on 16 patent applications since Apr 2016. Clients include 14 organizations from pharma, biotech, VC, CRO's and academia with projects spanning immunology, oncology, immuno-oncology, antibacterials, antivirals, antifungals, medical devices, rare diseases, and artificial intelligence.

Leading medicinal chemistry and drug development to address unmet medical needs in oncology, immunology, infectious diseases and organ transplantation. Heavy emphasis placed on FBDD, computationally-guided optimization of small molecules, and leveraging in-house co-crystal X-ray structures. Responsibilities include establishing and leading external chemistry, biology and DMPK collaborations across Europe, Asia and the US.

Led medicinal chemistry and rational drug design activities for internal oncology R&D projects. Focused on implementing and optimizing in-house expertise in artificial intelligence and computational chemistry. Responsibilities included establishing and managing external chemistry, biology and DMPK collaborations in Europe and Asia.

Inventing drug molecules for the treatment of cancer and inflammatory conditions including CV6-168 which has completed pre-clinical development and about to enter clinical trials. Responsibilities include leadership of medicinal chemistry, pharmacology, process R&D and managing external collaborations.

Provided scientific and strategic guidance to 37 clients in the USA & UK for integrated drug R&D programs. Responsibilities included refining scientific services business strategy and generation of new business. Supported 18 collaborations generating >$20MM in revenue and spearheaded a risk-sharing collaboration with a VC firm to create a start-up focused on novel cancer therapeutics.

Executive team member of Immunology R&D comprising 115 colleagues in Japan, US, & UK, reporting to the Unit President. Co-led a 60-member international discovery group, responsible for producing drug candidates for autoimmunity. Defined strategy & co-governed a portfolio of > 20 projects.Key Achievements:• Oversaw advancement of 3 compounds into preclinical development for autoimmune diseases.• Delivered 3 additional series of compounds to neuroscience & oncology pipelines.• Motivated teams to successfully compress project timelines 50% over expectations.• Revised discovery strategies to align with evolving patient needs.• Forged strategic alliances via CROs, KOLs & other partnerships to improve productivity.• Revolutionized innovation management resulting in > 10 promising new projects.• Created decision analysis tools to enable swift & transparent decision-making.• Spearheaded adoption of E-lab notebooks by ~200 chemists across 3 continents.• Implemented knowledge sharing platform for ~2,000 scientists across multiple functions & locations.

Sr. Principal Scientist <- Sr. Scientist <- Scientist <- Sr. Research Investigator <- Research Investigator Led group of 5 Medicinal Chemists, reporting to the chemistry department head. Instigator & leader of an automated chemistry team, contributing to oncology, neuroscience & inflammation projects. Served as Chemical Hygiene Officer & HAZMAT Incident Commander. Scientific Advisory Board member for a chemistry-enabling technology company (Biotage).Key Achievements:• Advanced 2 compounds from early discovery through IND-enabling studies, as global team leader• Helped deliver other candidates for malaria, RA, psoriasis, cancer & infection• Championed other projects through early discovery milestones: sepsis, IBD & MS• Achieved project milestones in half the anticipated time frames

• Designed & synthesized novel kainoids as potent insecticides

• Synthetic organic chemist, lab safety coordinator & supervisor of 2 associate-level scientists• Contributed to a fungicide project that resulted in the billion $ product AMISTAR (azoxystrobin)• Instrumental in the discovery & advancement of other fungicidal compounds to development• Investigated & optimized compounds as plant growth regulators

• Process chemistry for the heart drug Manoplax (flosequinan)

• Research of novel materials for the lining of blast furnaces, space shuttles & other applications

• Analytical QC chemist