Markus Heller, Phd Email & Phone Number

Vancouver, British Columbia, Canada

• As Senior Scientist, my primary responsibilities were conducting virtual screens for multiple projects, and optimization of hit compounds as part of Medicinal Chemistry project teams. I participated in project reviews.
• Guided over a dozen drug discovery projects using structure- and ligand-based virtual screening and cheminformatics techniques.
• Developed a workflow for small molecule docking with flexible receptor side chains using open-source software.
• Acted as liaison between academic Principal Investigators, industrial clients and internal clients delivering prompt, time-sensitive results.
• Participated in over two dozen project planning processes providing expertise in structural biology, computational as well as medicinal chemistry, thereby enabling the project management team to arrive at a go / no go.
• Selected to participate in a high-profile project to develop potential antibiotic against Gram-negative bacteria which resulted in the project agreement being signed and initiated.

Vancouver, British Columbia, Canada

As Senior Scientist, my primary responsibilities were conducting virtual screens for multiple projects, and optimization of hit compounds as part of Medicinal Chemistry project teams. In 2019, CDRD and Neomed merged to form adMare Bioinnovations.

Vancouver, British Columbia, Canada

• As NMR Scientist, my primary responsibility was getting the NMR infrastructure up and running. I trained internal as well as external Scientists in magnet safety and NMR data acquisition, processing and interpretation..
• Managed operation and maintenance of NMR facility/equipment supporting ~10 Medicinal Chemists and co-op students. Achieved minimal downtime and performed most of the repairs personally without having to have a.
• Co-designed and implemented a cost recovery system for NMR services which was the first for the company and is still in use today.
• Created infrastructure for computer-aided drug discovery; successfully applied structure- and ligand-based virtual screening techniques to drug discovery projects.
• Planned infrastructure and housing for NMR instruments in new building in close collaboration with manufacturer.
• Co-authored five peer-reviewed publications.

Characterized a novel, secondary Xylan binding site using NMR-derived protein dynamics.Determined the structure of a tricyclic peptide capable of inhibiting tumor cell invasion.

Applied solid- and solution-state NMR techniques to gain insights on mechanisms of protein function and inhibition.Supervised students during practical lab courses (NMR spectroscopy, Organic Chemistry)