Martha Gadd Email & Phone Number

Jacksonville, Florida, United States

• Prepared pre-clinical documentation for inclusion in Investigational New Drug Application (IND) 29622 “Autologous T-cells transduced with lentiviral vector expressing chimeric antigen receptor (CAR) targeting B-cell activating factor receptor (BAFFR) that is Mayo Clinic Florida’s first in-house CAR T-cell currenting in a Phase I clinical trial• Author, organize, and collate grant applications for internal and external funding opportunities by collaborating with MCF OSPA office for internal and federal funding applications and awards.• Write and prepare a range of documents that include but are not limited to: IACUC animals protocols, proposal grant sections, supporting documents for grants, manuscripts, white papers, abstracts, benefactor slide decks, benefactor grant applications, progress reports, letters of intent to funding organizations, internal presentation slides, invention disclosures, refine graphs and data representations, generate schematics of scientific concepts.• Strategic innovation by performing literature reviews and searches, journal club/team presentations, date review, grant strategic planning in collaboration with research partners.

Jacksonville, Florida, United States

Write and prepare a range of documents that include but are not limited to: IACUC animals protocols, proposal grant sections, supporting documents for grants, manuscripts, white papers, abstracts, benefactor slide decks, benefactor grant applications, progress reports, letters of intent to funding organizations, internal presentation slides, invention disclosures, refine graphs and data representations, generate schematics of scientific concepts. reparation of grants with accompanying documentation for federal, research institute, or industry funding. Support CAR T Cell therapy Director.

I help clients within the ocular arena to address scientific challenges specific to the anterior segment of the eye.

Jacksonville, Florida Area

Critical and Strategic Thinking | Communication | Research Skills:I perform experiments to support new product research and for the launch of novel medical device products, contact lenses. I have experience in creating and characterizing contact lenses using spectroscopic techniques as well as determining effects of contact lens care solutions on contact lens performance. I prepare all types of documents relevant to experiments and presentation of results to team and strategic partners. My research armamentarium is extensive and used to solve problems of all types.Innovation | New Target Validation | Building Relationships | Project Management:I am experienced with multi-functional teams and specialized in target identification and quantification. I have identified and managed eight domestic and international collaborative agreements to accelerate novel disease interception projects to achieve milestones in less than three years while adhering to a tight budget. I negotiated the statement of work and budget and timelines before preparing final documents necessary for Legal and Finance departments. I also managed and analyzed the data and prepared technical reports, upholding corporate standards for documentation in preparation for regulatory submission. I manage Design Control documentation.RESEARCH TOOLS: HPLC; UV/VIS spectroscopy; contact lens fabrication; data management; data analysis; CRO identification, protocol design, and management of externally performed in vitro and in vivo studies for six domestic and international CROs or academic partners; evaluation of data generated by CROs; subject matter expert for in vitro and in vivo studies for lens studies; management of people and resources for in vitro testing studies; extensive authorship of various research reports for executive team; data integrity compliance; contact lens production & association testing, HPLC; laboratory management, compliance & safety.

Jacksonville, Florida Area

Innovation | New Target Validation | Building Relationships:I solve problems using all resources at my disposal. I tapped into my biochemistry expertise to identify targets as well as to develop methods to quantify those targets. I supported the research efforts from several platforms, providing data and reports in a timely manner. Designed new methods for internal testing and prepared SOPs and work aids.Communication | Strategic Thinking:I was a member of various internal teams where I provided strategic input for new projects, existing devices, and future goals as the subject matter expert for general biochemistry and ocular surface processes. Prepared and presented presentations to various levels of personnel in the organization. RESEARCH TOOLS: Protein and lipid extraction and quantification; enzyme characterization and kinetics; in vitro method development; electrophoresis; Western blots/ ELISA/plate reader testing; CRO identification and management of data; in vitro biomarker testing; training and supervising junior lab members; SOP and technical report authorship; UV/VIS spectroscopy; worked in BCL-2 laboratory.

Fort Worth, Texas

Leadership | Innovation | New Target Identification/Validation | Disease Mechanism Understanding: Created a Topical Ocular Analgesic Program with the identification of two lead compound classes by developing an in vivo screening funnel that queried 22 target compounds classes in a single year thereby providing a new ocular target class to the company portfolio. Leadership | Project Management | Management of Cross-Functional Team: Managed 4 researchers and engaged 6 other disciplines/functionalities to strategically advance a lead compound within the Topical Ocular Analgesic portfolio as the Project Team Leader, developing a novel knowledge base in ocular pain targets and experimental methodologies. Communication | Strategic Thinking: Strong communication skills that allow for project maintenance and integration of company oriented goals, presenting the Analgesic Program at the 2012 Alcon Research Council meetingBuilding Alliances | Communication: Prepared and monitored outside research contracts with academic collaborators and CROs as well as prepared internal protocols to satisfy internal compliance standards.RESEARCH TOOLS: In vivo small animal model development; animal husbandry; HPLC; Western blotting; Protein expression and purification; enzyme kinetics with and without radiolabeled compounds; protein extraction and analysis methods; electrophoresis; Western blots/ ELISA; NSAID and analgesic compound design and testing; in vitro biomarker testing; team leader/management; extensive authorship of technical reports, animal protocols, SOPs, regulatory documents sections, and internal reports for executive team.

Fort Worth, Texas

Project Management | Disease Mechanism | Screening | Strategic Thinking: Acted as Project Manager and established research collaborations that answered questions of target engagement, mechanism of action of compounds of interest, and basic science questions that positively impacted R&D strategic direction. Disease Mechanism | Strategic Thinking: Developed a comprehensive understanding of the function and mechanism of action of ocular NSAIDs for inclusion in company strategic decisions. Method and Model Development | Screening: Developed eight in vivo rodent models to understand ocular diseases with numerous accompanying in vitro assays to characterize biomarkers and proteins to understand disease processes and to identify targets for Drug Discovery.Documentation | Communication | Intellectual Property | Regulatory Affairs: Prepared scientific and project-related documents ranging from research protocols to technical reports to white papers in order to maintain compliance, to establish intellectual property, and to support future regulatory submissions.Regulatory Affairs | Communication: Prepared preclinical data package and regulatory documentation, collaborated with Alcon Japan on correct translation of sections, and answered regulatory questions required for the approval of Nevanac® in Japan (contributing to the $200 million / year Nevanac® total). Regulatory Affairs | Communication | Strategic Thinking:Conducted seminal experiments supporting feasibility of a once-a-day formulation of nepafenac, prepared preclinical data package and regulatory documentation required for the approval and launch of Ilevro™, for the pain and inflammation associated with cataract surgery (projected growth with upcoming indication is $500 million / year).

Columbus, Ohio

• Identified a novel mitochondrial protein in which its activity was modulated by membrane potential using the technical skills of biochemistry, enzyme kinetics, and mitochondrial bioenergetics resulting in significant implications in apoptosis. • Awarded National Research Service Institutional Research Training Grant Fellow through the Department of Internal Medicine, Division of Pulmonary and Critical Care.• Championed postdoctoral career issues as a founder and member of the Executive Committee Member of David Heart and Lung Research Institute Postdoctoral Scholars Association.• Solicited speakers, participants, and resources as member of the organizing committee of 1st -3rd Annual OSU Health Center Postgraduate and Graduate Research Day, now a yearly event.RESEARCH TOOLS: HPLC; MS/GC; Western blotting; Protein expression and purification; mitochondrial isolation; mitochondrial bioenergetics; enzyme kinetics; Atomic Absorption Spectroscopy; UV/VIS spectroscopy; electrophoresis; preparation of sample for MALDI-TOF.

Greater Atlanta Area

• Experienced in biochemistry and molecular biology of Gaq family member.• Awarded National Research Service Award for “Biochemical & Functional Diversity of Gaq Family Members” receiving a priority score of 150 (4.5%)RESEARCH TOOLS: mammalian cell culture (sf9 and COS); Primer design, PCR, and subcloning into insect and mammalian expression vectors (pBacPak and pEGFP); engineering and expression of fusion construct; cell fractionation; protein expression and purification; Ni-NTA chromatography; agarose and gel electrophoresis; PLCg assays.

Phd, Biochemistry And Molecular Genetics

Project: “Characterization of the Interaction of Phospholipase A2 with Binary Lipid”. RESEARCH TOOLS: Protein mutagenesis methods using E..

Interesting Classes

Anatomy & Physiology I & II, Microbiology, Human Nutrition, Psychology & Human Development, Statistics

B.S., With Distinction In Biochemistry, Biochemistry, Summa Cum Laude

B.S. Senior honors thesis: “Nitrosation of Thiol Enzymes” Techniques of enzyme kinetics, UV/VIS spectroscopy, chromatography.

Drawing And Oil Painting