Mary Simcox Email & Phone Number

• Over 10 years of oncology research and development experience at Roche• Experienced group and project leader with successful track record including delivery of small molecule and antibody therapeutics for clinical development • Led the Roche Global Oncology Target Selection Team• As member of Global Oncology Research Senior Leadership Team, developed research strategy, managed the project portfolio, oversaw research projects and managed the research budget. • Developed research portfolio in-licensing strategy and served as the chief scientific evaluator for in-licensing opportunities. 5 years of due diligence experience as scientific evaluator.• Successfully managed a group of 13 scientists, including 5 Ph.D. level scientists. Group activities ranged from new target validation to biomarker and combination studies to support early (e.g. RG7212, anti-TWEAK mAb) and late development projects (e.g. Vemurafenib). • Led RG7212, an anti-TWEAK antibody research project from target entry into the portfolio to Phase I clinical testing. Developed candidate response prediction and pharmacodynamic markers implemented in the trial• Wrote preclinical pharmacology sections and post-marketing approval documents for Health Authority/Regulatory submissions.

Listed skills include Drug Discovery, Oncology, Biomarkers, Clinical Development, and 46 others.