Mary Kushman, Ph.D., M.P.H. Email & Phone Number

Silver Spring, Maryland, United States

Calverton, Md

• Supervises a team of three to six toxicologists of varying experience levels in CTP's Office of Science, Division of Nonclinical Science, as their first managerial point-of-contact for work matters, including secondary/tertiary review of regulatory applications, distribution of workload, and performance evaluations.• Lead author on and contributor to key scientific memoranda for Division, leader of review teams for various regulatory submissions, and subject matter expert in areas of hazard assessment and systematic review.

Calverton, Md

• Directly supervised three supervisory team lead toxicologists, each of whom led a team of three to six toxicologists, pharmacologists, and biologists.• Communicated regularly with Division and Office leadership on matters related to scientific and professional activities/initiatives and involvement of branch personnel.• Led biweekly branch meetings, disseminating and discussing information pertaining to Center, Office, Division, and Branch activities.• Provided feedback on Division research priorities, scientific memoranda, regulatory submissions, and provided input as a subject matter expert when and where warranted.

Silver Spring, Maryland, United States

• Familiar with day-to-day schedules of reviewers, including regulatory review workload across several different submission pathways, workgroup participation, and research project participation.• Ensures even distribution of workload amongst team members.• Recommends team members for review of regulatory submissions and other division and center activities as appropriate for reviewer’s workload, interests, and experience level.• Serves as a mentor for and observes training needs of primary review staff, making recommendations to staff members and supervisors to encourage professional growth and ensure performance goals are met.• Provides routine feedback on performance.

Silver Spring, Maryland, United States

• Performed primary, secondary, and tertiary toxicological review of regulatory submissions in the context of whether the products within raise different questions of public health• Developed systematic frameworks to synthesize and present scientific evidence for research questions relevant to CTP priorities.• Led a workgroup focusing on systematic review.• Co-authored peer-reviewed scientific papers on modes and mechanisms of action of tobacco toxicants and their relevance to smoking-related diseases.• Served as a point of contact for several research projects relevant to tobacco use, exposure, and toxicity for NIH- and CTP-funded grants.

Silver Spring, Maryland, United States

See above description overviewing GS-13 duties.

Development and implementation of systematic literature review frameworks and presentation of scientific evidence for health risk assessments, development of chemical hazard characterizations, and toxicological reviews. Special emphasis on evidence identification, selection, and presentation for chemical mode-of-action as related to carcinogenicity.Specific accomplishments include:*Development of criteria to determine the adequacy of toxicological and epidemiological studies.*Co-authored toxicological reviews of environmental and industrial chemicals as an integral part of multidisciplinary teams.*Performed major literature review, critical toxicity analysis and interpretation, and context of toxic and carcinogenic potential of phthalate esters, with particular emphasis on analysis of in vivo data for translation of toxicity to humans, conducted in collaboration with interdisciplinary teams of investigators.*Work selected for presentation at 2013 Society of Toxicology Annual Meeting.*Work featured in the UNC Gillings School of Global Public Health news for October 31, 2012, and in the Association of Schools of Public Health Friday Letter, November 9, 2012. Manuscript submitted to RegulatoryToxicology and Pharmacology.*Invited speaker at US EPA symposia, ICF International, and Integrated Risk Information System (IRIS) meetings.

Philadelphia, Pa

Worked alongside junior and senior scientists assisting with technical writing, report presentation, and grant preparation in the areas of virology, immunology, and tropical medicine.

Advised Philadelphia-area contract research organizations and biotech startups on matters of protection of their intellectual property, proprietary assay development, and business development strategies.

Preparing summaries of technology from FCCC available for licensing and working to identify potential licensees for said technologies. Exposure to records of invention, drafted patent applications, and advised on proper handling of confidential material.

Designed and executed research problems relevant to carcinogen metabolism in human lung cell lines. Regularly presented research findings at international conferences and to laboratory group as part of routine in-house group meetings. Also responsible for aspects of laboratory management such as maintenance of cell culture facilities, carcinogen stocks, and chemical hygiene protocols.Three presentations at American Chemical Society or Society of Toxicology annual meetings, and appeared as a co-author publication in Chemical Research in Toxicology.Relevant skills: Radiometric reverse-phase high-pressure liquid chromatography, liquid scintillation counting, organic solvent extraction, real-time PCR, SDS-PAGE, Western blotting, protein purification, UV/visible spectroscopy, ethoxyresorufin-O-deethylase activity assay, aldo-keto reductase enzyme activity assays, and mammalian cell culture. Familiar with liquid chromatography/mass spectrometry.

Proposed research problems relevant to DNA polymerase bypass of bulky nucleic acid adducts. Research findings and proposals regularly discussed in front of laboratory group and departmental research specialty section.Relevant skills:Fast-pressure liquid chromatography, SDS-PAGE, Western blotting, and growth of bacterial cell cultures. Familiar with Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF).

Investigated protective mechanisms against the toxicological action of polycyclic aromatic hydrocarbons in cells engineered to express specific human cytochrome P450 and glutathione-S-transferase isoforms.Eight presentations at American Association for Cancer Research annual meetings or International Society for the Study of Xenobiotics meeting, and published in Carcinogenesis, Mutation Research, and Toxicological Sciences.

Designed and performed studies investigating bioenergetics of normal versus cancerous breast epithelial cells.

Master Of Public Health (Mph), Environmental Sciences And Engineering

Phd, Cancer Biology

Activities and Societies: Student Representative, Curriculum Committee, Department of Cancer Biology, WFUSM, 2002-2005. Sought.

Ms, Molecular Biology And Biotechnology

Activities and Societies: Beta Beta Beta Biological Honor Society President, 1998-1999.Relevant skills: Mammalian cell culture, Western.

Bs (Cum Laude), Physics (Biophysics)

Activities and Societies: Sigma Pi Sigma Physics Honor Society (Secretary), Sarah Patterson Lane Award for Undergraduate Achievement.

Education record

Top 2% of graduating high school class. Active in science and math activities with multiple Science Olympiad awards. Served as an officer.