Mathew Abraham Email & Phone Number

West Point, Pennsylvania

• Facilitate collaborative initiatives with drug discovery teams specializing in infectious diseases, vaccines, formulations/delivery, chemistry, and neuroscience. • Execute comprehensive due diligence projects to meticulously assess the biodistribution and effectiveness of external assets (drug/protein delivery platforms).• Propose, design, evaluate, and execute studies focusing on uncovering pivotal insights into drug mechanism of action, pharmacokinetics/biodistribution, assessing… Show more • Facilitate collaborative initiatives with drug discovery teams specializing in infectious diseases, vaccines, formulations/delivery, chemistry, and neuroscience. • Execute comprehensive due diligence projects to meticulously assess the biodistribution and effectiveness of external assets (drug/protein delivery platforms).• Propose, design, evaluate, and execute studies focusing on uncovering pivotal insights into drug mechanism of action, pharmacokinetics/biodistribution, assessing efficacy, quantifying disease burden, and evaluating biomarker responses to treatments.• Develop and implement dynamic research strategies guided by data-driven decision-making to demonstrate adaptability and responsiveness to evolving project requirements. Show less

West Point, Pennsylvania

• Conceptualized hypothesis, designed/executed studies, and delivered results in multiple therapeutic area projects• Managed multimodality imaging studies (optical, uCT, and MRI) to understand the MoA, PK, and biodistribution of novel vaccine and drug formulations• Project leader of imaging studies to generate pre-clinical data on LNP-mRNA and controlled-release vaccine/drug formulations in multiple animal models, including transgenic animals• Developed and conducted cell-based… Show more • Conceptualized hypothesis, designed/executed studies, and delivered results in multiple therapeutic area projects• Managed multimodality imaging studies (optical, uCT, and MRI) to understand the MoA, PK, and biodistribution of novel vaccine and drug formulations• Project leader of imaging studies to generate pre-clinical data on LNP-mRNA and controlled-release vaccine/drug formulations in multiple animal models, including transgenic animals• Developed and conducted cell-based assays using pseudoviruses/reporter viruses to understand the mechanism of viral entry to support the investigations on the antiviral therapeutic targets• Developed and validated novel in vivo imaging studies and image analysis platforms to track biomarkers for neuroscience and sensory biology (pain) programs Show less

Philadelphia, Pennsylvania, United States

• Complete batch records and other required documentation according to and in compliance with GMP and SOPs• Verification of test methods for in vitro assays to detect adventitious viral contaminants in biological products

Hopkinsville, Kentucky

• Monitored processes and policies for veterinary diagnostics and regulatory compliance to ensure accreditation standards for the diagnosis of animal diseases. • Secured CISR competitive research grant to detect Bovine viral diarrhea virus in cervids using antigen-capture ELISA.• Supervised laboratory personnel, prepared diagnostic laboratory reports and released test results. Course teacher of undergraduate AGR-400 (Microbiology)

Athens, Georgia Area

• J Paramyxovirus (JPV)-based study to understand the role of Small hydrophobic (SH) protein in pathogenicity. (Published in Journal of Virology: Abraham, et. al, 2018)• Developed paramyxovirus-vectored poultry, swine, and human vaccines by incorporating foreign antigens into its genome. My studies showed that the deletion of JPV genes or gene segments responsible for virulence is a safe and efficient way to develop vectored-vaccines. (Published in Journal of Virology: Abraham, et. al… Show more • J Paramyxovirus (JPV)-based study to understand the role of Small hydrophobic (SH) protein in pathogenicity. (Published in Journal of Virology: Abraham, et. al, 2018)• Developed paramyxovirus-vectored poultry, swine, and human vaccines by incorporating foreign antigens into its genome. My studies showed that the deletion of JPV genes or gene segments responsible for virulence is a safe and efficient way to develop vectored-vaccines. (Published in Journal of Virology: Abraham, et. al, 2021)• Developed a real-time in vivo bioluminescent imaging platform to track the disease progression of JPV in mice. This system was used in the parainfluenza virus-5 (PIV-5)-based influenza vaccine development in our laboratory. (Published in NPJ vaccines, 2017) Show less

Athens, Georgia Area

• Board-certification training to qualify for (Diplomate) American College of Veterinary Microbiologists - ACVM• Close interaction and communication with faculty, technicians, and clients on the areas of veterinary infectious diseases and diagnostic microbiology/serology. • Hands-on experience with handling a wide variety of infectious agents• Animal disease diagnostic test interpretation

Athens, Georgia Area

• A comparative study of the virulence of different strains of Histomonas meleagridis in turkeys. Expression of virulence factors of Histomonas meleagridis. (Published in Veterinary Parasitology, 2020)• Poultry preclinical trials to determine the sensitivity of Histomonas meleagridis to arsenical compounds.(Published in Avian Diseases: Abraham, et. al, 2014)• Assessment of protective immunity against the blackhead disease in turkeys based on the in vitro attenuated strains of Histomonas… Show more • A comparative study of the virulence of different strains of Histomonas meleagridis in turkeys. Expression of virulence factors of Histomonas meleagridis. (Published in Veterinary Parasitology, 2020)• Poultry preclinical trials to determine the sensitivity of Histomonas meleagridis to arsenical compounds.(Published in Avian Diseases: Abraham, et. al, 2014)• Assessment of protective immunity against the blackhead disease in turkeys based on the in vitro attenuated strains of Histomonas meleagridis. • Teaching Assistant of undergraduate course POUL 3050 – Molecular Diagnostic and Research Tools in Avian Biology Show less

Kerala, India

General veterinary practice in ruminants, companion animals and poultry.

Kerala, India

• Identified the ova of endoparasites causing gastroenteritis in cattle of Wayanad district of Kerala, India. • Mapping of endoparasitic diseases of cattle of Wayanad district. • Generated data on use of anthelmintic for control of parasitic gastroenteritis. • Identified the epidemiological factors involved in the occurrence of parasitic gastroenteritis.

Combined Ph.D.-Clinical Microbiology Cmcp Fellowship (Ph.D. Awarded In Infectious Diseases), Virology, Immunology & Molecular Biology

Activities and Societies: American Society for Virology (ASV) Dissertation - Molecular pathogenesis of J paramyxovirus, a prototype.

Residency - Clinical Microbiology, Veterinary Microbiology Residency Program

Activities and Societies: American Association of Veterinary Laboratory Diagnosticians (AAVLD), American Veterinary Medical Association.

Master Of Science (M.S.), Parasitology

Activities and Societies: American Association of Veterinary Parasitologists (AAVP) Dissertation - Blackhead disease: Variation.

Veterinary Medicine, Veterinary Sciences/Veterinary Clinical Sciences, General

Dissertation - Coprological Survey of Gastrointestinal Parasites of Dairy Cattle