Mathew Jennison Email & Phone Number

Philadelphia, Pa, Us

Cambridge, England, United Kingdom

• Project manager of several multidisciplinary projects, leading to the achievement of key company milestones• Preparation of detailed project plans including estimated timelines, resource allocation risk identification and assessment, key milestone identification, project scoping and outlining of deliverables• Management of multidisciplinary teams that included biologists, physicists, chemists and engineers• Review of both in house and external literature to develop solutions to… Show more • Project manager of several multidisciplinary projects, leading to the achievement of key company milestones• Preparation of detailed project plans including estimated timelines, resource allocation risk identification and assessment, key milestone identification, project scoping and outlining of deliverables• Management of multidisciplinary teams that included biologists, physicists, chemists and engineers• Review of both in house and external literature to develop solutions to presented technical challenges• Design and optimisation of synthetic routes to key intermediates and functionalised nucleotide phosphoramidites (mgs initial route identification to 100’sG scale process development), the protocols developed were utilized by internal and external process development teams • Bio conjugation and modification of oligonucleotides and dsDNA, which resulted in the successful development of a novel surface attachment strategy compatible with the other components of the technology• Design and synthesis of thermally and chemically cleavable protecting groups and linkers, achieving this was contributed to the successful raising of series B2 funding• Collaboration with external contractors (national and international) in order to achieve key deliverables (external project management, weekly update meetings, remote troubleshooting, tech transfer and in person visits to ensure the adherence to provided standard operating procedures) • Supervision and mentoring of junior team members from the synthetic and surface chemistry departments• Lead role in recruiting of new team members (growth from two members to 18 members over tenure) Show less

Cambridge, England, United Kingdom

• Technical expert on multiple projects simultaneously, covering the areas of synthetic chemistry, analytical quality control and surface functionalisation strategies• Design of synthetic routes and synthesis of challenging molecules from mg to 100’s g scale• Development of novel molecules with improved reaction kinetics based on SAR (structural activity relationships) of previously synthesized analogues and computational modeling, resulting in the publication of three patents• Lead… Show more • Technical expert on multiple projects simultaneously, covering the areas of synthetic chemistry, analytical quality control and surface functionalisation strategies• Design of synthetic routes and synthesis of challenging molecules from mg to 100’s g scale• Development of novel molecules with improved reaction kinetics based on SAR (structural activity relationships) of previously synthesized analogues and computational modeling, resulting in the publication of three patents• Lead technical authority for the companies suite of LCMS instruments (Waters Acquity, Waters Bioaccord, Agilent 1290), developing analytical methods for the analysis of small molecules and large bio molecules (oligonucleotides and proteins), training of staff on equipment use and data analysis, maintenance and troubleshooting of the systems and the technical consultant when purchasing new equipment• Supervision of projects outsourced to external contractors, successfully delivering large scale key intermediates• Outlining and management of sub projects to deliver on critical milestones of larger projects Show less

Cambridge, England, United Kingdom

• Design and synthesis of novel chemical entities to advance the progress of the thermally controlled DNA synthesis research program• Equip lab from the ground up, implementing relevant health and safety protocols and logistical requirements• Collected and recorded synthetic results to a high standard using Electronic lab notebook (ELN) software• Maintenance, troubleshooting and daily housekeeping of analytical instruments and laboratory equipment

Liverpool, United Kingdom

Development of viable synthetic organic routes (via literature searches and chemical knowledge) to desired target molecules, carrying out said synthetic routes and solving related issues. These range from a milligram scale to 50 grams.• Purification of compounds using HPLC, LC and semi preparative LC-MS• Synthetic route optimisation and development to increase efficiency of the route and lower cost of final product• Interpretation of NMR (1H, 13C, NOESY, COESY and 19F) and LCMS data… Show more Development of viable synthetic organic routes (via literature searches and chemical knowledge) to desired target molecules, carrying out said synthetic routes and solving related issues. These range from a milligram scale to 50 grams.• Purification of compounds using HPLC, LC and semi preparative LC-MS• Synthetic route optimisation and development to increase efficiency of the route and lower cost of final product• Interpretation of NMR (1H, 13C, NOESY, COESY and 19F) and LCMS data for characterisation of compounds.• Proposition of new target molecules using computational chemistry software (Pymol, Cresset etc) and knowledge of bioisososters.• Intellectual property rights searches in order to determine the patent status of proposed small molecule inhibitors and undertaking “patent busting” to define the exact claims of said patent. • Maintaining an electronic notebook to a high standard.• Curation and presentation of synthetic chemistry, medicinal chemistry and DMPK data at key monthly departmental meetings.• Writing of patent experimental sections.• Routine maintenance and repair of rotary evaporators, vacuum pumps and semi preparative LCMS systems. This also involved leasing with suppliers and maintenance engineers. Show less

Liverpool, United Kingdom

I undertook my industrial placement year for my masters degree in chemistry at Redx oncology. The role involved the planning and exicution of synthetic routes with the aim of developing novel drug candidates.

Master Of Chemistry, Chemistry, 2:1 (69%)

Activities and Societies: University of York jiu-jitsu club (President 2011-2012)

Education record

A Levels; Biology (A), Psychology (A), Chemistry (B), General Studies (A) AS level; Geography (A)

Education record

13 GCSE's A-C