Department of Neurology/Taub Institute for Research on Alzheimer’s Disease and the Aging BrainRoles:• Train and supervise a team of 5+ researchers, including pre-med research assistants, a post-doctoral associate scientist, research associates, and students, to conduct government-funded studies. Design/set up experiments, schedule tasks, define expectations, discuss results and future directions, and adjust strategy when necessary• Develop and perform the analytical and clinical validation of highly sensitive immunoassays to evaluate the utility of novel biomarker candidates associated with neurological disorders• Work with Principal Investigator on budgets, grant proposals, and progress reports, often under tight deadlines• Mentor employees on Good Laboratory/Clinical Practices (GLPs/GCPs) and International Standards defined by the International Organization for Standardization (ISO). Provide guidelines and write/revise standard operating procedures (SOPs)• Systematize laboratory logistics to facilitate resource sharing. Collaborate with on- and off-campus laboratories, facilities, and companies• Conduct employee evaluationsAchievements:• Published with team members an opinion piece on endolysosomal dysfunction in neurodegenerative diseases, discussing current progress and future direction in the use of exosomes as biomarkers• Generated and organized quantitative biomarker data for Columbia University’s Alzheimer's disease Research Center (ADRC) and on/off-campus collaborators

Department of Pathology/Taub Institute for Research on Alzheimer's Disease and the Aging Brain• Generated data for 2 peer-reviewed scientific publications• Analyzed and organized data for posters and presentations• Set up and ran behavioral tasks to assess and quantify cognition in non-transgenic and transgenic models, using novel object recognition, object-context recognition, object displacement, T-maze alternation, odor-guided task, Morris water maze, virtual maze, and social interaction• Wrote a series of protocols based on publications and experience• Trained and advised students and new hires• Requested, inventoried (Biobank) and processed human biological samples to extract pathological proteins (PHFs) in compliance with GCP/GLP standards• Processed and analyzed human biofluids (CSF, plasma) using Simoa technology, and human brain tissue/extract with Tau ELISA and Western blot• Techniques: Magnetic Resonance Imaging (MRI), electrophysiology, optogenetics, open field, PHF/pathological protein extraction, Tau ELISA, Simoa HDX assay, stereotaxic surgery, injections, pump placement, immunohistochemistry (IHC), and immunofluorescence (IF)

Department of Pathology/Taub Institute for Research on Alzheimer's Disease and the Aging Brain• Generated data and draft for 7 peer-reviewed scientific publications• Investigated trans-cellular propagation of low-molecular-weight Tau species in microfluidic-based primary culture• Wrote and revised protocols• Techniques: Primary culture, microfluidics, organotypic slice culture, cell culture, immunocytochemistry (ICC), and Confocal Microscopy

Content Marketing Platform offering data, redaction web, web content, and SEO• Wrote a series of articles on the regulations and use of clean rooms for an international company involved in the distribution of research laboratory products• Analyzed the content of a draft for an ebook and provided advice to add content, reorganize the outline and suggest different strategies

New York State Department of Mental Hygiene/New York Psychiatric Institute/Nathan S. Kline Research Institute• Generated data and draft for 8 peer-reviewed scientific publications• Revised protocols• Organized laboratory supplies, created inventories and enforced good practices to comply with internal guidelines and policies• Techniques: Protein extraction, ultra-centrifugation, protein assay, spectrophotometry, sucrose density gradient fractionation, microtubule/kinase assay, immunoprecipitation (IP), Agarose/Polyacrylamide gel electrophoresis, Native/SDS-PAGE, and Western blotting