Matilda Sinkko Email & Phone Number

United Kingdom

Creating multilayer AI models for diagnostic and research purposes, such as breast cancer detection. Using digital training data to teach AI to detect distinct morphological features. Optimising parameters for different AI models to develop the best model for the specific use case. Post-processing the image analysis results. Data-analysis and visualisation.

Modelled the functional impact of gene variants associated with severe neuropsychiatric disorders on neuronal development using high-throughput genomic approaches in iPSC derived neuronal cells. Conducted exploratory analysis and quality assessment in high-dimensional RNA sequence data using R software. Performed for example principal component analyses.

Interviewed people exposed to COVID-19 to assess symptoms, refer to testing and book appointments. Determined social support needs and handled issues that arose according to established protocols. Provided instructions for isolation or quarantine and reported every case following the confidentiality procedures.

In my master thesis project, I was studying neuromuscular junction formation and morphology in early onset peripheral neuropathy. I established an in vitro neuromuscular junction model with iPSC derived motor neurons and myotubes using microfluidic devices. I studied the effect of mutation in MCM3AP gene on the neuromuscular junction development using gene.

London, United Kingdom

My project was to search interesting gene variants associated with ALS throughout patient databases and design guide RNAs for CRISPR editing to create iPSC lines carrying the patient variants. Finding these rare variants and understanding the role in disease development may in future help to develop personalized treatment options for ALS patients.

Helsinki, Finland

I was studying the effect of novel neurotrophic factor CDNF on the development of neurodegenerative disorders such as ALS. I was using two different mouse models, C9orf72 and SOD1-G93A, to understand the neurorestorative effect of CDNF. In my research, I gained experience in wide variety of different in vivo and in vitro methods focusing especially on.

Bern, Switzerland

I performed my exchange studies in Switzerland. As part of the Neurodegenerative Diseases Laboratory, I was studying the mitochondrial impairment and ER stress in ALS using molecular biology and specialized microscopy techniques.

I was responsible for the group of 3 years old children. My duties included planning and implementing teaching activities and supporting children’s social and emotional skills. I always prioritized children’s safety and wellbeing and my interest was to use instructional methods to motivate and stimulate children’s individual abilities and lifetime learning.

Master'S Degree, Data Science

Relevant courses: Applied Machine Learning Big Data Clouds, Grids and Virtualisation Statistical Methods for Time Series Analysis Graph.

Master'S Degree, Translational Medicine

The aim of TRANSMED is to provide a solid basis for either academic or non-academic careers in the health sector. TRANSMED graduates are.

Bachelor'S Degree, Molecular Bioscience

Education record