Matt Beech Email & Phone Number

United Kingdom

Oxford

Part of the Ineos Oxford Institute (IOI) for Antimicrobial Research, working in the group of Prof. Chris Schofield, FRS.- Protein Purification and Characterisation- High-throughput assay development- Analytical techniques such as LC-MS, NMR- Structural Biology (X-ray Crystallography, NMR)

Department Of Chemistry, University Of Warwick

• PhD in Chemical Biology funded by the Midlands Integrative Bioscience Training Partnership (MIBTP). Worked on synthesis of chemicals probes to investigate protein-protein interactions of nonribosomal peptide.
• Designing and carrying out the synthesis of chemical probes
• Complex analytical techniques, including multidimensional NMR, HPLC, LC-MS and intact protein mass spectrometry
• Cloning of recombinant plasmid DNA
• Expression, purification and of recombinant proteins
• Reconstitution of biosynthetic reactions in vitro

Birmingham, United Kingdom

3 month research placement developing assays to evaluate importance of domain architechture in the dimerisation of polyketide synthase proteins. This work will aid the design of protein engineering towards production of novel analogues of the MRSA antibiotic mupirocin.

Coventry, United Kingdom

Completed a 3 month internship in business development as a part of my PhD programme. Responsible for identifying and following up on opportunities for University of Warwick chemistry and biosciences research groups in commercialisation, marketing and collaboration.

Department Of Chemistry, Challis Group

• Completed my final year project under the supervision of Greg Challis entitled 'Investigating the role of a methylcobalamin-dependent radical-SAM methyltransferase in watasemycin biosynthesis' for which I was awarded.
• Organic synthesis of natural products
• Design of synthetic routes towards complex products with multiple stereocentres
• Structural analysis by mass spectrometry and NMR spectroscopy
• Bacterial culture and assay design
• Presentation of results

Stevenage

• Worked as a synthetic organic chemist in a medicinal chemistry group developing novel therapeutics targeting chronic immuno-inflammatory indications.Skills acquired include:
• Organic synthesis of pharmaceutical compounds
• Synthetic route design to allow quick access to multiple derivatives
• Design of synthetic targets based on crystallography and biological assay data
• Collaboration with computational chemists to aid drug design
• Presentation of results at chemistry conference

University Of Warwick

• Worked in the lab of Prof. David Haddleton at the interface of chemistry and material science developing methodology for the production of novel in-adhesive drug patches for the effective transdermal delivery of some.
• Adherence to health and safety protocols
• Laboratory technique and experimental design
• Compositional analysis by application and optimisation of gas chromatography
• Communication of scientific data through reports and poster presentationsThe work carried out here provided the foundation from which the University of Warwick spin-out company Medherant Ltd was founded. More.

Mchem, Chemistry, 1St Class Honours

Activities and Societies: Radio at Warwick; Warwick Improvised Theatre SocietyOverall mark = 84%, for which I was awarded the Infineum.

Maths, Chemistry, Biology, Physics, A*A*A*A

Activities and Societies: College representative