Matteo Pigni Email & Phone Number

Lausanne, Vaud, Switzerland

La-Chaux-De-Fonds, Neuchâtel, Switzerland

- Analytical testing and analytical-method development within a GMP-regulated environment.- Project support for batch release, stability, validation, and tech transfer

Epalinges, Vaud, Switzerland

Projects:- Characterization of the mechanisms of synergistic TLR-dependent activation of dendritic cells through CRISPR/Cas9-mediated gene editing of synergistically regulated phosphorylation sites.- Participation in a team effort aimed to use tolerogenic dendritic cells to prevent and/or treat autoimmune diseases in vivo.Main responsibilities: - Designed and carried out experiments and data analysis in the context of original research projects- Presented results in internal meetings and department meetings- Contributed to the implementation of team’s projects- Contributed to writing scientific articles and reports- Supervised master students- Assisted in practical-work classes for bachelor’s students in medicine and biology

Epalinges, Vaud, Switzerland

Projects: - Establishment and characterization of immortalized dendritic cell lines. - Study of the molecular mechanisms of TLR-ligand-mediated synergistic activation of dendritic cells through the screening of a genomic CRISPR/Cas9 knockout pooled library.Main responsibilities: - Designed and carried out experiments and data analysis in the context of original research projects- Presented results in internal meetings and department meetings- Wrote and published research articles in peer-reviewed journals- Contributed to the implementation of team’s projects- Supervised master students- Assisted in practical-work classes for bachelor’s students in medicine and biology

Milan, Lombardy, Italy

Project: in vitro analysis of the biochemical interactions between the recombinant human transcription factors NF-Y and USF.Main responsibilities:- Contributed to a research project by participating in experiment design, execution and analysis- Heterologously expressed, purified and folded in vitro the recombinant subunits of the human transcription factor NF-Y- Purified anti-NF-Y antibodies through affinity chromatography- Presented results in internal meeting- Scientific reporting to supervisors

Milan, Lombardy, Italy

Project: Cloning of genes from a genomic library of S. cerevisiae and identification of the gene Stm1 as a suppressor of sensitivity to hydroxyurea in an S. cerevisiae mutant defective for S-phase cell cycle checkpointMain responsibilities:- Contributed to a research project by executing and analyzing experiments- Scientific reporting to supervisors

Doctor Of Philosophy - Phd, Life Sciences - Cancer And Immunology

Thesis director: Prof. Hans Acha-Orbea

Master Of Science - Ms, Molecular Biotechnology And Bioinformatics, 110/110 Cum Laude

Thesis supervisor: Prof. Roberto Mantovani Thesis co-supervisor: Dr. Nerina Gnesutta

Bachelor Of Science - Bs, Industrial And Environmental Biotechnology, 108/110

Thesis supervisor: Prof. Marco Muzi Falconi Thesis co-supervisor: Dr. Fabio Puddu